Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
WHO Collaborating Centre For Research and Training On Diarrhoeal Diseases
Dr. Shanta Dutta MD, Ph.D., Scientist G, National Institute of Cholera and Enteric Diseases, Kolkata, is a clinical microbiologist and a medical research scientist. After graduated in Medicine from Calcutta National Medical College under the University of Calcutta in 1986, she completed postgraduation in Medical Microbiology from the Kasturba Medical College, Manipal, Mangalore University in 1992. She has joined NICED, a constituent Institute of the Indian Council of Medical Research (ICMR) and a WHO Collaborating Centre for Research and Training in Enteric Diseases, in August 1994 and presently holding the post of Scientist G (Director) in the Division of Bacteriology.
She was awarded with RONPAKU fellowship of JSPS (Japanese Society for Promotion of Science) during 2001-2005 by Dept. of Science and Technology, M/O Science and Technology, Govt. of India (Indian counterpart) and was conferred with Ph.D. Degree from Kyushu University, Japan in 2006 under this program. During this fellowship she gained experience of working on virulence, antimicrobial resistance and molecular epidemiology of enteric bacterial pathogens in the Department of Bacteriology, Kyushu University, Fukuoka, Japan. She was selected to participate in the Advanced WHO course on "Immunology, Vaccinology, Biotechnology and Biosafety applied to Infectious Diseases", held in Lausanne, Switzerland during Sept. - Oct., 1996. She has participated in the International course of laboratory diagnosis of Diarrhoeal Diseases, at ICDDR,B Dacca, Bangladesh during August 2002.She has been elected as a member of the National Academy of Medical Sciences (India) (MAMS) in the year 2013 In recognition of significant contribution for the advancement of medical Sciences.She is actively involved in research, training and teaching of the microbiological aspect of enteric diseases including diarrhea, enteric fever, water bacteriology. She has interests in exploring antimicrobial resistance of enteric pathogens, mechanism of drug resistance and antibacterial activity of bioactive molecules derived from herbal products. She has worked as principal investigator in a number of intramural and extramural funded projects. She supported the microbiology component of the studies pertaining to other divisions like epidemiology and clinical as a co-investigator and responsible for timely feedback of results to the concerned divisions. She took part in the vaccine trial of Typhoid vaccine (Vi polysaccharide vaccine), disease burden study of typhoid, randomized control clinical trials on usefulness of probiotics in acute diarrhea, role of vit A, micronutrients in acute watery diarrhoea. She acted as an expert in the UNICEF funded project on "Drinking water quality monitoring by H2S KIT" and participated as the nodal person in the multi-centric study on evaluation and operational research of the kit. On ICMR request, she was also involved in the evaluation of solar disinfection method of drinking water in rural household (SODIS).
She has published a number (>65) of original research articles in peer-reviewed national and international journals in the area of Clinical Microbiology, Molecular Epidemiology and Pathogenesis of enteric pathogens, water bacteriology including book chapters. She attended various national and international conferences and presented papers on her research studies. She served as an invited reviewer of a number of national and international reputed journals like Journal of Antimicrobial Chemotherapy, Diagnostic Microbiology Infectious Diseases, Journal of Medical Microbiology, PloS One, BMC infectious Diseases, International Journal of Infectious Diseases, WHO Guidelines. She has been invited to become editorial international board member of various publishing agencies.
Name | Dr. Shanta Dutta |
---|---|
Designation | Director & Scientist G |
Date of joining ICMR | 3rd August, 1994 |
Date of joining present post | 12th July, 2016 |
Discipline | Clinical / Public Health Microbiology |
Division | Bacteriology |
Specialization | Clinical Microbiology with special reference to Gastrointestinal Infectious diseases |
drshantadutta@gmail.com ,
shanta.niced@icmr.gov.in , shanta1232001@gmail.com |
|
Academic Qualification | |
Graduation | MBBS, Calcutta Univ., India, Nov. 1986 |
Post Graduation | MD (Medical Microbiology), Mangalore Univ., India, Dec. 1992 |
Doctoral | Ph.D. (Medical science), Kyushu University, Japan, Mar 2006 |
Dr. Dutta has more than 30 years of research experience
in the field of Gatrointestinal infectious diseases. She
is actively involved in field based epidemiological
studies as well as laboratory based molecular studies of
the bacterial strains, both clinical and environmental
origin, w.r.t. their antimicrobial resistance (AMR)
markers, mechanism of AMR, virulence markers and
sequence based molecular subtyping of clinical isolates.
She focuses on basic, operational, implementation
research on Gastrointestinal diseases, antimicrobial
resistance and transmission dynamics of infectious
diseases by spread of enteric pathogens with reference
to entero-virulent Escherichia coli, Shigella,
Salmonella and V. cholerae species. She participated in
the clinical and vaccine efficacy trials against
typhoid, cholera, covid 19 and was involved in the
burden estimation of various diseases. In view of the
emergence of AMR bacteria she explored the antibacterial
activity of various medicinal plant extracts, which lead
to new herbal formulations effective against resistant
bacteria. As a public health service provider, she
participated in the investigation of several disease
outbreaks across India, participated in national/
international (WHO) meetings/ conferences as an expert/
invited speaker and deliberated views on practices and
policies in contemporary health issues. Other research
interests include bacterial population genetics,
evaluation of new/ existing diagnostic tests for enteric
diseases along with development of more user friendly
and comprehensive point of care tests, enteric candidate
vaccines evaluation and efficacy testing of candidate
vaccines, estimation of viral disease burden based on
sero-surveillance etc. She has published more than 300
articles in the high impact peer reviewed journals. She
took part in collaborative multicentric projects as
Principal site investigator of the studies which were
supported by national/international funding agencies.
She became invited reviewer of a number of international
peer reviewed journals and project reviewer of national
and international funding agencies. Attended national
and international conferences and delivered her views as
a consultant/ member of steering committee/advisory
committee/ Research Review committee/ national and
international research forum. She is the member of
Technical Working Group (TWG) of Oral Cholera Vaccine (OCV)
the Global Task Force of Cholera Control Committee (GTFCC).
She is the internal/ external examiner for reviewing
thesis of PhD students, impart training to the post
graduate students of various national universities to
complete their intended projects. She is a registered
guide of PhD students to accomplish the dissertation
goals. In recognition to her contribution in the field
of enteric diseases, she was conferred with awards and
fellowship of National research bodies like NASI, NAMS,
WAST etc.
Her research focuses on both applied and basic aspects of enteric infectious diseases and enteric pathogens with special reference to entero-virulent Escherichia coli, Shigella, Salmonella and V. cholerae species. Studying phenotypic and genetic characters of various enteric bacteria and analyzing the results are her major research interest. In view of the emergence of antimicrobial resistance, exploring antibacterial activity of herbal extracts is other area, where she puts in efforts, which lead to new products with strong antibacterial potential. She has interest in research including bacterial population genetics, evaluation of new/ existing diagnostic tests for enteric diseases along with development of more user friendly and comprehensive point of care tests, enteric candidate vaccine evaluation and efficacy testing, estimation of disease burden based on sero-surveillance etc.
Title of the project: Scientific Evaluation of
anti-typhoid claim.
Funding Agency: NIF-DST Task Force
Duration: 2008-2010
Role: PI
Title of the project: In vitro studies on Novel
approach of Vaccination with cocktail of LPS immunogen
derived from common Salmonella Sp.
Funding Agency: ICMR
Duration: 2013-2014
Role: PI
Title of the project: NICED-Regional Virus
Research Diagnostic Lab
Funding Agency: DHR, GOI
Duration: : 2016 – ongoing
Role: PI
Title of the project: Studies on the molecular typing S. Typhi isolates of Kolkata its relevance in controlling
the drug-resistant organisms.
Funding Agency: WB DST
Duration: 2014-2017
Role: PI
Title of the project: A multi-centric study to estimate
the sero-prevalence of dengue virus infection in India
Funding Agency: ICMR, Delhi
Duration: 2017-2018
Role: PI
Title of the project: Preparation of NOSODE from
Escherichia coli and Vibrio cholera: the preclinical
effectiveness and safety evaluation
Funding Agency: Central Council for Research in
Homeopathy (CCRH), Delhi
Duration: 2017-2019
Role: PI
Title of the project: National Surveillance System for
Enteric Fever in India (NSSEFI)
Funding Agency: BMGF through CMC, Vellore, India
2017-2020
Role: PI
Title of the project: Immunogenicity and Safety of Rotavac® and Rotasiil® Administered in an
Interchangeable Dosing Schedule among Healthy Indian
Infants: A Multicentric, Phase IV, Open-Labelled,
Randomized, Controlled Trial (RVICS)
Funding Agency: MoH&FW, GoI through ICMR
Duration: 2018-2020
Role: PI
Title of the project: Evaluation of a Typhoid Conjugate
Vaccine Introduction Program - Navi Mumbai Municipal
Corporation, India
Funding Agency: WHO, India
Duration: 2018-2020
Role: PI
Title of the project:
Sanipath Typhoid - Assessment of Typhoid Exposure
Pathways In Low-Income Urban Settings
Funding Agency: Emory University
Duration: 2018-2021
Role: PI
Title of the project: Etiology of Childhood Pneumonia in
India: An ICMR Task Force Study
Funding Agency: ICMR, Delhi
Duration: 2018-2020
Role: Coordinator
Title of the project: Human pulmonary paragonimiasis in
crab eating communities and smear negative suspected TB
cases from some states of India
Funding Agency: ICMR, Delhi
Duration: 2019-2021
Role: PI
Title of the project: Strengthening Laboratory
Surveillance for Pneumococcal Meningitis in India to
Understand the Impact of Pneumococcal Conjugate Vaccine
(PCV) rollout
Funding Agency: ICMR, Delhi
Duration: 2019-2022
Role: PI
Title of the project: National Repository of
Antimicrobial Resistant Bacterial Isolates (NRAMRB) at
ICMR-NICED: A Pilot study
Funding Agency: ICMR-Delhi
Duration: 2019-2020
Role: PI
Title of the project: Rational use of drugs
Funding Agency: ICMR-Delhi
Duration: 2019-2022
Role: PI
Title of the project: Centre for Product Development and
Rational Use of Drugs
Funding Agency: ICMR-Delhi
Duration: 2019-2024
Role: PI
Title of the project: Mobile application for
immunization data in India (MAIDI)
Funding Agency: ICMR-NICED
Duration: Feb 2020 for 9 months
Role: PI
Title of the project: Estimation of V. cholerae O1
infection in India: a step towards identification of
cholera hotspots
Funding Agency: ICMR-Delhi
Duration: Aug. 2020 for 4 months
Role: PI
Title of the project: Establishment of ten ICMR-Biorepositories for COVID-19
Funding Agency: ICMR-Delhi
Duration: Sept. 2020 for 6 months
Role: PI
Title of the project: An Event-driven, Phase 3,
Randomized, Double-blind, Placebo-controlled,
Multicenter study to evaluate the efficacy, safety,
immunogenicity and Lot-to-Lot consistency of BBV 152, a
Whole-virion inactivated SARS-CoV-2 vaccine in adults
≥18 years of age
Funding Agency: ICMR-Delhi
Duration: December 2020
Role: CoI
Title of the project: Impact of improved diagnostic
tools practices training and communication on acute
fever case management and antibiotic prescriptions for
children, and adolescents presenting at outpatient
facilities in the community clinics of ICMR-NICED, India
Funding Agency: ICMR-Delhi and FIND
Duration: March 2021 for 18 months
Role: PI
Title of the project: National Repository of
Antimicrobial Resistant Bacterial (NRAMRB): a facility
under the "AMR Hub" for addressing AMR research across
India
Funding Agency: ICMR-Delhi
Duration: August 2021 for 3 yrs.
Role: PI
Title of the project: Priorities for the environmental
dimension of Antimicrobial Resistance (AMR) in India
Funding Agency: UNEP
Duration: July 2021 for 6 months
Role: PI
Title of the project: A Prospective, Multicentre,
Randomized, Active-controlled, Observer-blind, Phase II
study seamlessly followed by a Phase III study to
evaluate the Safety, Tolerability and Immunogenicity of
the candidate HGCO19 (COVID-19 vaccine) in healthy
subjects.
Funding Agency: Gennova Biopharmaceuticals Ltd.
Duration: December 2021 for14 months
Role: PI
Title of the project: Centre of Excellence for
Climate Change and Waterborne Diseases
Funding Agency: NCDC, Delhi
Duration: Jan 2022 for 3 months
Role: PI
Title of the project: Emerging antimicrobial
resistance in enteric pathogens with special reference
to Shigella species
Funding Agency: NIID, Japan
Duration: 2019 - 2024
Role: PI
Title of the project: Development of new medicine
for diarrhea derived from traditional Indian folk
medicine
Funding Agency: AMED, Japan through Okayama University,
Japan
Duration: 2020 - 2025
Role: PI
Title of the project: A novel diagnostic tool to
aid vaccine evaluation and surveillance of
enterotoxigenic E. coli and Shigella
Funding Agency: NIH, USA through Johns Hopkins
University, USA
Duration: 2018 - 2021
Role: PI
Title of the project: Adaptative molecular
diagnostics
Funding Agency: Cambridge University through THSTI,
Faridabad, India
Duration: 2021 - 2022
Role: PI
Title of the project: A Phase III, open label,
multicenter, parallel group randomized clinical study to
compare the immunogenicity and safety of Euvichol-Plus
vaccine with Oral Cholera Vaccine Shanchol in healthy
adults and chi9ldren above age of one years
Funding Agency: Tech Invention
Duration: January 2022 for 6 months
Role: PI
Title of the project: A Phase III, open label,
multicenter, parallel group randomized clinical study to
compare the immunogenicity and safety of Euvichol-Plus
vaccine with Oral Cholera Vaccine Shanchol in healthy
adults and chi9ldren above age of one years
Funding Agency: Tech Invention
Duration: January 2022 for 6 months
Role: PI
Title of the project: A demonstration project for
reduction of Tuberculosis in India – A multicentric
study
Funding Agency: ICMR
Duration: 15/01/2023 to 14/01/2024
Role: PI
Title of the project: A Phase II/III, Multicenter,
Double-Blind, Randomized, Active Controlled Study to
evaluate Safety and Immunogenicity of SII Inactivated
Salk Polio Vaccine (Adsorbed) in comparison with SII
(Serum Institute of India) Licensed Inactivated
Poliovirus Vaccine (IPV)
Funding Agency: Serum Institute of India Ltd.
Duration: August 2023
Role: PI
Title of the project: Development of a sustainable
network of laboratories in India for identification,
monitoring and research on viruses causing acute
encephalitis syndrome and other novel pathogens through
capacity building in advanced biomedical technologies
Funding Agency: PM-ABHIM by ICMR
Duration: September 2023
Role: PI
Title of the project: DOMI project of IVI:
Disease burden study of typhoid fever and cholera in
eastern Kolkata, West Bengal, India.
Funding Agency: BMGF through IVI
Duration: 2002-2004
Role: Co-I
Title of the project: Phase IV effectiveness
trial of Vi vaccine against typhoid
Funding Agency: BMGF through IVI
Duration: 2004-2006
Role: Co-I
Title of the project: Surveillance
for Dengue fever in Eastern Kolkata, West Bengal, India.
Funding Agency: BMGF through PDVI
Duration: 2008-2010
Role: Co-I
Title of the project: An
Event-driven, Phase 3, Randomized, Double-blind,
Placebo-controlled, Multicenter study to evaluate the
efficacy, safety, immunogenicity and Lot-to-Lot
consistency of BBV 152, a Whole-virion inactivated
SARS-CoV-2 vaccine in adults ≥18 years of age
Funding Agency: ICMR-Delhi
Duration: December 2020
Role: CoI
Hospital based Surveillance system for Diarrhoeal
Diseases
Studies on mechanism of antimicrobial resistance especially
fluoroquinolone resistance among Salmonella Typhi Kolkata
isolates
Studies on evolution of flouroquinolone and azithromycin
resistance in Salmonella Typhi blood isolates
Studies on antimicrobial resistance & molecular subtypes of
Gram Negative bacilli isolated from hospitalized sepsis
patients.
No. of Publications - 330; Book Chapters - 8; Book Review - 1