NICED : Scientists

Dr. Nilanjan Chakraborty

Dr. Nilanjan Chakraborty is Scientist in the ICMR institute, National Institute of Cholera and Enteric Diseases (NICED), Kolkata working in the field of virology for over a decade. Dr. Chakraborty has work experiences in the fields of microbiology and virology. He graduated in 1984, gained his Masters in Botany with Microbiology in 1987 from Kalyani University, and did his Ph. D. from Kalyani University in 1995. He joined ICMR Virus Unit, Kolkata as Scientist C in the year 2003 and his current position is Scientist E in the virus research laboratory of NICED.

Upon joining Virus Unit, Dr. Chakraborty committed himself on learning the distribution of different opportunistic infections prevalent among the HIV infected patient groups of Eastern India. Furthermore, he extended the work to deduce the drug susceptibility profile of Mycobacterium tuberculosis isolated from HIV-infected and uninfected Pulmonary Tuberculosis patients which provided some significant observations regarding the prevalence and rise of XDR-TB and MDR-TB strains in Eastern India. His research to apprehend the frequency of multiple herpes virus infection among the HIV seropositive patients provided a clear insight in identifying the baseline values of demographic and behavioral factors associated with these opportunistic infections.

His effort is to understand and decipher the epidemiological prevalence pattern, socio-demographic, clinical characteristics and molecular phylogeny of Human cytomegalovirus among the infected patients of Eastern Indian population. Currently he is studying the molecular characterization of congenital rubella infection (among the pediatric population) and Chikungunya infection.

Dr. Chakraborty has trained a number of students about the essential concepts of virus research. Currently three students are registered for Ph.D. and one is doing post doctoral research under his guidance. One of his students has been awarded Ph.D. and is now doing post-doctoral work. He is the author of a large number of research papers in peer-reviewed international journals and also book chapter on the aspect of Virology.

Key Achievements
During his initial years as a scientist, Dr. Chakraborty committed himself on learning the distribution of different opportunistic infections prevalent among the HIV infected patient groups of Eastern India. Furthermore, he extended the work to deduce the drug susceptibility profile of Mycobacterium tuberculosis isolated from HIV-infected and uninfected pulmonary tuberculosis patients which provided some significant observations regarding the prevalence and rise of XDR-TB and MDR-TB strains in Eastern India. His research to apprehend the frequency of multiple herpes virus infection among the HIV seropositive patients provided a clear insight in identifying the baseline values of demographic and behavioural factors associated with these opportunistic infections. Later on he has focussed his attention to understand and decipher the infectivity pattern, epidemiological prevalence, socio-demographic, clinical characteristics and molecular phylogeny of Human cytomegalovirus among different patients group in eastern India. He is also involved in the identification and characterization of noble anti-HCMV compounds from natural resources. Dr. Chakraborty has trained a number of students about the essential concepts of human cytomegalovirus research. Currently four students are registered for Ph.D. under his guidance of whom one has already submitted his doctoral thesis. One of his students has been awarded Ph.D. and is now doing post-doctoral work. He is the author of a large number of research papers in peer-reviewed international journals and also book chapters on different aspects of Virology.

Present work details
Currently Dr. Chakraborty is working to develop a comparative assessment of the different demographic, biochemical and immunological parameters associated with the clinical conditions of HCMV infection in infants and HIV1 seropositive patients for proper diagnosis and therapeutic remedy. He intends to identify specific predictive markers of disease occurrence after thoroughly analysing the pattern in the expression of the different significant parameters. The identification of these markers will help to generate a superior defining criterion for identifying and monitoring such cases, thereby providing a greater therapeutic advantage to the clinicians. Furthermore suitable effort has also been put forward to understand the role of specific immunological pathways in the same context. He is also studying the genetic variation among the clinical HCMV strains infecting different tissue sites and causing different clinical manifestations.
His team is also working on in-vitro HCMV infection models to test the potential of some isolated natural compounds as anti-viral agents. Simultaneous studies are being carried out to understand the mechanism of action of these selected compounds against HCMV.
A part of his team is also working to understand the epidemiology of Chikungunya virus infections among different patient groups in eastern India

Future prospects
Preparations are on-going to begin the molecular detection of HCMV infection and characterization of symptoms associated with HCMV viremia among patients undergoing renal transplantation at different metropolis hospitals of Kolkata. In this regard he and his team intends to analyze different host risk factors (physical, demographic, biochemical, hematological and immunological) associated with HCMV infection among these patients.
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Profile

Publications

2022

1. Chatterjee, A., Roy, D.,Mukherjee, S., Ghosh, H., Maiti, A., Basu, R., & Chakraborty, N. (2022). Acomparative analysis depicting the disease characteristics and phylogeneticsignature of human cytomegalovirus infection in Human Immunodeficiency Virus 1 seropositivepatients with end-organ retinitis and gastro-enteric diseases. Scientificreports, 12(1), 7617. https://doi.org/10.1038/s41598-022-11727-2

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2020

1. Chatterjee, A., Mukherjee, S., Basu, B., Roy, D., Basu, R., Ghosh, H., Mishra, L., Bhattacharya, M., & Chakraborty, N. (2020). Insight into the distinctive paradigm of Human Cytomegalovirus associated intrahepatic and extrahepatic cholestasis in neonates. Scientific Reports, 10(1), 1-16. https://doi.org/10.1038/s41598-020-73009-z

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2. Chatterjee A, Mukherjee S, Basu B, Roy D, Basu R, Ghosh H, Bhattacharya M, Chakraborty N. A cross-sectional study exploring disease characteristics and phylogenetic nature of human cytomegalovirus among infected neonates with congenital nephrotic syndrome. Pediatr Nephrol. 2020 Jul;35(7):1257-1266. Pubmed

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3. Chatterjee A, Chakraborty N. Association of Human Cytomegalovirus Infection with Different Forms of Diabetes. Interventions Obes Diabetes 2020 Apr; 4(1). IOD.000576. 2020.

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4. Roy D, Ansari S, Chatterjee A, Luganini A, Ghosh SK and Chakraborty N. In Vitro Search for Antiviral Activity against Human Cytomegalovirus from Medicinal Mushrooms Pleurotus sp. and Lentinus sp. J Antivir Antiretrovirals. Jun 2020; 12(201), 1-7

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2019

1. Sarkar A, Das D, Ansari S, Chatterjee RP, Mishra L, Basu B, Ghosh SK, Bhattacharyay M, Chakraborty N. Genotypes of glycoprotein B gene among the Indian symptomatic neonates with congenital CMV infection. BMC Pediatr. 2019 Aug 22;19(1):291. Pubmed

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2017

1. Chatterjee A, Thakur I, Ansari S, Chatterjee RP, Sarkar R, Guha SK, Chakraborty N. (2017) "A Comparative Insight into the Incidence of Steven Johnson Syndrome/Toxic Epidermal Necrolysis among the Immunocompromized Patient Populace of Eastern India with a Distinctive Emphasis on the Possible Association of Human Cytomegalovirus." J AIDS Clin Res 8:706. doi:10.4172/2155-6113.1000706.

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2. R.P. Chatterjee, A. Chatterjee, N. Chakraborty, S. Chatterjee, - A Seroepidemiological insight into the current into the current status and rapid dissemination of Chikungunya virus infection in West Bengal-A two years' retrospective study; Int. J. Sci. Res. Vol-6, Issue-9, Sept-2017.

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3. Incidence of Japanese encephalitis virus infection in West Bengal, India - a two years comprehensive study"; R.P.Chatterjee, A.Chatterjee, N.Chakraborty and S. Chatterjee; Int. J. Adv. Res. 5(3), 61-65, March (2017), doi: 10.21474/IJAR01/3485

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2016

1. Chatterjee A, Ansari S, Sarkar A, Mishra L, Bhattacharya M, Chakraborty N et al. (2016). Congenital Cytomegaloviral Infection Causing Severe Pulmonary Hypertension in a Newborn with a HIV Seropositive Mother - A Case Report from Eastern India. J AIDS Clin Res 7:567. doi:10.4172/2155-6113.1000567

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2. Sarkar A, Chatterjee A, Ansari S, Chakraborty N (2016). Characterization of Molecular Mimicry between UL18 Glycoprotein of Human Cytomegalovirus [HCMV] and Class-I MHC Molecule through Pattern-based Analysis: An In-silico Approach. J Health Med Informat 7: 230. doi:10.4172/2157-7420.1000230

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3. Chatterjee A, Sarkar A, Ansari S, Siddhanta S, Banerjee S, Sarkar R, Chakraborty N. Spread of human immunodefciency virus 1 among men who have sex with men is emerging as a genuine social concern and affecting the general populace - case reports from Eastern India. World J Virol 2016; 5(4): 183-188 DOI: http://dx.doi.org/10.5501/wjv.v5.i4.183

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4. Aroni Chatterjee, Lopamudra Mishra, Agniswar Sarkar, Rajendra P Chatterjee, Sabbir Ansari, Mala Bhattacharya and Nilanjan Chakraborty. Diagnostic dilemma in reckoning cytomegaloviral infection is prompting increased mortality among abandoned newborns of India. Int J Med Res Health Sci. 2016, 5(12):43-47.

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5. Aroni Chatterjee, Agniswar Sarkar, Lopamudra Mishra, Rajendra P Chatterjee, Mala Bhattacharya and Nilanjan Chakraborty. Congenital Cytomegalovirus Infection Causing Severe Inclusion Diseases in infants- Case Report from Eastern India. Int. Res. J. Biological Sci. 2016, Vol. 5(12), 49-51.

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2015

1. Avirup Chakraborty, Tanmay Mahapatra, Sanchita Mahapatra, Sabbir Ansari, Sattik Siddhanta, Siwalik Banerjee, Dipanjan Banerjee, Rathindra Nath Sarkar, Subhashish Kamal Guha, Nilanjan Chakraborty. Distribution and determinants of Cytomegalovirus induced end organ disease/s among people living with HIV/AIDS in a poor resource setting: observation from India. PLOS One. DOI: 10.1371/journal.pone.0117466 February 13, 2015.

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2014

1. Avirup Chakraborty, Sattik Siddhanta, Chandrav de, Sohinee Bhattacharyya, Shuvashish Kamal Guha, Krishnendu Sarkar, Nilanjan Chakraborty*Cytomegalovirus retinitis with multiple co infections in a HIV/ AIDS patient having extreme low CD4 count: A case report and review of literature. Journal of AIDS and Clinical Research. 2014, 5:12. doi:10.4172/2155-6113.1000394. 

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2013

1. Chakraborty Avirup, Siddhanta Sattik, Bhattacharyya Kuntal, Das Amit, Banerjee Siwalik, Sarkar Rathindra Nath, Datta Utpal Kumar, Chakraborty Nilanjan*. Unraveling the Gordian knot: diagnostic dilemma in an HIV- positive patient with neurological involvement. BMJ Case Report 2013 Apr 23;2013. doi: pii: bcr2012008524. 10.1136/bcr-2012-008524.PMID: 23616316. 

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2012

1. Chakraborty Avirup, Patil Krishna, Dasgupta Sanjay, Tarafdar Avijit, Chakrabarti Shekhar, Chakraborty Nilanjan*. Incidence of HCMV-HCV coinfection in renal transplant recipient. BMJ Case Report 2012 Apr 2; 2012. doi: pii: cr1220115314. 10.1136/bcr.12.2011.5314.PMID: 22602835.

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2010

1. Nilanjan Chakraborty, Sohinee Bhattacharyya, Chandrav De, Anirban Mukherjee, Dwipayan Bhattacharyya, Santanu Santra, Rathindra N Sarkar, Dipanjan Banerjee, Shubhashish K Guha. Utpal K Datta, Sekhar Chakrabarti. Incidence of multiple herpes virus infection in HIV seropositive patients, a big concern for Eastern Indian scenario. Virology Journal, 2010.7:141 doi: 10.1186/1743-422X-7-147.

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2009

1. Nilanjan Chakraborty, Sohinee Bhattacharyya, Chandrav De, Anirban Mukherjee, Santanu Santra, Dipanjan Banerjee, Rathindra Nath Sarkar, Shubhashish Kamal Guha. Drug susceptibility profile of Mycobacterium tuberculosis isolated from HIV-infected and uninfected Pulmonary Tuberculosis patients in Eastern India. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010.104,195-201. doi: 10.1016/j.trstmh.2009.09.004.

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2. Nilanjan Chakraborty, Sohinee Bhattacharyya, Chandrav De, Anirban Mukherjee, Rathindra Nath Sarkar, Dipanjan Banerjee, Sekhar Chakraborti, Sujit Kumar Bhattacharyya. A rapid immuno chromatographic assay for the detection of Mycobacterium tuberculosis antigens in pulmonary samples from HIV seropositive patients and its comparison with conventional methods. Journal of Microbiological Methods, 2009.76, 12-17.doi: 10.1016 /j.mimet. 2008.09. 005.

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3. Anurodh Shankar Agrawal, Mehuli Sarkar, Souvik Ghosh, Mamta Chawla-Sarkar, Nilanjan Chakraborty, Meena Basak, Trailokya Nath Naik. Prevalence of respiratory syncytial virus group B genotype BA-IV strains among children with acute respiratory tract infection in Kolkata, Eastern India. Journal of Clinical Virology, 2009. 45:358-361. doi: 10.1016/j.jcv.2009.05.013.

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2008

1. Nilanjan Chakraborty, Anirban Mukherjee, Santanu Santra, Rathindra Nath Sarkar, Dipanjan Banerjee, Shubhashish Kamal Guha, Sekhar Chakraborty, Sujit Kumar Bhattacharyya. Current trends of opportunistic infections among HIV -seropositive patients from Eastern India. Japanese Journal of Infectious Diseases.2008 January; 61 (1):49-53.

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2007

1. Nilanjan Chakraborty, Kamalesh Sarkar. Baishali Bal, Syed Iftikar Ahmed, Rita Mukherjee, Sekhar Chakraborty, Swapan Kumar Niyogi, Arunangshu Talukder, HIV Infection among Transport Workers Operating through Siliguri-Guwahati national Highway, India. Journal of the International Association of Physicians in AIDS Care. 2007 March; 6(1):56-60. doi: 10.1177/1545109706298405.

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Book Chapters

1. Chapter title: HIV-Co Opportunsitic Infections -a Current Picture in Tropical Climatic Eastern Indian Seropositive Population in in book entitled: 'HIV Infection' ISBN 978-953-307-306-4. October, 2011.

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