ICMR - NICED


ICMR-National Institute of Cholera and Enteric Diseases

आई सी एम आर - राष्ट्रीय कॉलरा और आंत्र रोग संस्थान

Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
WHO Collaborating Centre For Research and Training On Diarrhoeal Diseases

NICED : Scientists

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Dr. Mainak Bardhan.jpg

Dr. Mainak Bardhan

 

General Information
Name Dr. Mainak Bardhan
Designation Scientist B (Medical)
Date of joining ICMR 13 Sep 2021
Date of joining present post 13 Sep 2021
Discipline Molecular Microbiology
Division Bacteriology
Specialization  
Email : bardhan.mainak@icmr.gov.in , bardhan.mainak@gmail.com
Academic Qualification:  
Graduation Bachelor of Medicine and Bachelor of Surgery (MBBS): 2020
Pt Jawaharlal Nehru Memorial Medical College, Raipur, Chhattisgarh, India
Post Graduation  
Doctoral  

Profile

Research Experience

He has been involved in Clinical Research from 1st year of Medical School, beginning his journey through ICMR’s Short Term Studentship (STS), working on Sickle Cell Anaemia in the Department of Biochemistry, and attached Sickle Cell Institute Chhattisgarh. Thereafter he has continued to explore various avenues of Clinical research as Medical Students Research Trainee at CSIR CCMB Hyderabad and at CSIR IGIB, New Delhi, as Visiting Medical Student. In the Pre Final year of his Medical School, he presented his work at the University of Groningen, Netherlands. After that, during his final year of Medical School, he got selected for the prestigious Amgen scholars program with direction and technical assistance provided by Harvard University, being the only Medical Student from India to work at the School of Pharmaceutical Sciences (SPS) in Tsinghua University Beijing, China, ranked as the top University globally (ranked #17 in QS Global World Rankings 2022). He presented his work on Solute Carrier Transporters (SLCs) at the 2019 Amgen Asia Scholars Symposium at the National University of Singapore (NUS). Thereafter graduating from his Medical School, he joined the National Institute of Mental Health And Neurosciences (NIMHANS), Bengaluru, India, as a Senior Research Fellow in the Department of Neurology, where he worked on neurogenetics of Neuromuscular Disorders to build the National Registry for Rare and Other Inherited Disorders(NRROID) which is an ambitious multicentric project of ICMR. Continuing his work in clinical research, Clinical Genetics, and genomics, he is currently involved in Bacterial Genetics and Genomics in the context of molecular pathogenesis, antimicrobial resistance, strain evolution, disease surveillance to improve the health of the community through planning and formulation of better health actions and policies.

Research Interests

Dr. Bardhan’s research interests span clinical omics to develop and implement omics methodologies to answer pressing questions related to Microbes and their role in human health. He is also interested in genomics studies of indigenous populations understanding the genome to phenome basis of Human diseases, focusing on accessible and affordable diagnostics leading to personalized medicine.

Membership/ Fellow of Professional Societies/ Associations

  1. American Academy of Neurology
  2. European Academy of Neurology

Awards

  1. ICMR Nurturing Clinical Scientists Fellowship 2020-21
  2. Bursary winner XXV World Congress of Neurology (WCN 2021)
  3. Certificate of Excellence, Department of Science and Technology (DST), Faculty Training Program, Proteomics, Indian Institute of Technology, Bombay 2021
  4. Amgen Scholarship: 2019
  5. Ideathon winner and delegate of the 1st Noble Prize series of India, Department of Science and Technology, India: 2017
  6. ICMR Short Term Studentship (STS), Indian Council of Medical Research (ICMR), New Delhi, India:2016
  7. Gold Medal in Anatomy MBBS, Pt JNM Medical College, Raipur, Chhattisgarh, India, 2015
  8. Kishore Vaigyanik Protsahan Yojana (KVPY) fellowship awardee Department of Science and Technology, India: 2013
  9. National Bal shree zonal level camp at creative scientific innovation category, Ministry of Human Resource Development, India: 2010
  10. 17th National Children’s Science congress Best 100 Projects, Department of Science and Technology, India: 2009
    .

Travel to foreign countries to attend conference/ meetings

  1. As an Amgen Scholar, Dr Mainak Bardhan worked at Tsinghua University Beijing, China, in 2019
  2. Attended the 19th Amgen Scholar Asia Symposium at the National University of Singapore (NUS) to present his work on Solute Carrier Transporters
  3. Was selected to give an oral presentation in the 25th The International Student Congress Of (bio)Medical Sciences, University of Groningen, Netherlands

Publications

2021

  1. Bardhan M, Polavarapu K, Bevinahalli NN, Veeramani PK, Anjanappa RM, Arunachal G, Shingavi L, Vengalil S, Nashi S, Chawla T, Nagabushana D, Mohan D, Horvath R, Nishino I, Atchayaram N. Megaconial congenital muscular dystrophy secondary to novel CHKB mutations resemble atypical Rett syndrome. J Hum Genet. 2021 Mar 12. doi: 10.1038/s10038-021-00913-1. Epub ahead of print. Erratum in: J Hum Genet. 2021 Mar 26;: PMID: 33712684.
  2. Bardhan M, Pramanik D, Riyaz R, Hasan MM, Essar MY. Dual burden of Zika and COVID-19 in India: challenges, opportunities and recommendations. Trop Med Health. 2021 Oct 18;49(1):83. doi: 10.1186/s41182-021-00378-0. PMID: 34657633.
  3. Bardhan, M., Hasan, M.M., Ray, I. et al. Tuberculosis amidst COVID-19 pandemic in India: unspoken challenges and the way forward. Trop Med Health 49, 84 (2021). https://doi.org/10.1186/s41182-021-00377-1.PMID: 34674772.
  4. Bardhan M, Das I,Tiwari R,Amle D, Rath D. Assessment of Cormic Index in Sickle Cell Disease Subjects and Its Association with Clinical Severity.International Journal of Science and Healthcare Research. https://doi.org/10.52403/ijshr
  5. Polavarapu,K*.,Bardhan,M*.,Anjanappa,R.,Vengalil,S.,Veeramani,P.,Shingavi,L.,Chawla,T, Nashi,S.,Bevinahalli,N,Mohan,D.,Arunachal,G.,Nalini,A. Nemaline Rod / Cap myopathy due to novel homozygous mutations in MYPN gene: The first report from South Asia and a comprehensive literature review. J Clin Neurol. 2021 Jul;17(3):409-418. doi: 10.3988/jcn.2021.17.3.409. PMID: 34184449
  6. Nagabushana D, Polavarapu K, Bardhan M, Arunachal G, Gunasekaran S, Preethish-Kumar V, Anjanappa RM, Thomas P, Sadasivan A, Vengalil S, Nashi S, Chawla T, Warrier M, Keerthipriya M, Raju S, Mohan D, Nalini A. Comparison of The Carrier Frequency of Pathogenic Variants of DMD Gene in an Indian Cohort. J Neuromuscul Dis. 2021;8(4):525-535. doi: 10.3233/JND-210658. PMID: 33843695
  7. Siddiqui S, Polavarapu K, Bardhan M, et al. Distinct and Recognisable Muscle MRI Pattern in a Series of Adults Harbouring an Identical GMPPB Gene Mutation [published online ahead of print, 2021 Oct 8]. J Neuromuscul Dis. 2021;10.3233/JND-200628. doi:10.3233/JND-200628.PMID: 34633329
  8. Polavarapu K, Mathur A, Joshi A, Nashi S, Preethish-Kumar V, Bardhan M, et al . A founder mutation in the GMPPB gene [c.1000G > A (p.Asp334Asn)] causes a mild form of limb-girdle muscular dystrophy/congenital myasthenic syndrome (LGMD/CMS) in South Indian patients. Neurogenetics. 2021 Aug 1. doi: 10.1007/s10048-021-00658-1. Epub ahead of print. PMID: 34333724.
  9. Rajula RR, Saini J, Unnikrishnan G, Vengalil S, Nashi S, Bardhan M, Huddar A, Chawla T, Sindhu DM, Ganaraja VH, Polavarapu K, Preethish-Kumar V, Kandavel T, Nalini A. Muscle ultrasonography in detecting fasciculations: A noninvasive diagnostic tool for amyotrophic lateral sclerosis. J Clin Ultrasound. 2021 Oct 15. doi: 10.1002/jcu.23084. Epub ahead of print. PMID: 34653263..
  10. Rajula RR, Saini J, Unnikrishnan G, Vengalil S, Nashi S, Bardhan M, Huddar A, Chawla T, Sindhu DM, Ganaraja VH, Polavarapu K, Preethish-Kumar V, Kandavel T, Sathyaprabha TN, Nalini A. Diaphragmatic ultrasound: Prospects as a tool to assess respiratory muscle involvement in amyotrophic lateral sclerosis. J Clin Ultrasound. 2021 Oct 5. doi: 10.1002/jcu.23069. Epub ahead of print. PMID: 34609007.
  11. Huddar A, Polavarapu K, Preethish-Kumar V, Bardhan M, Unnikrishnan G, Nashi S, Vengalil S, Priyadarshini P, Kulanthaivelu K, Arunachal G, Lochmüller H, Nalini A. Expanding the Phenotypic Spectrum of ECEL1-Associated Distal Arthrogryposis. Children. 2021; 8(10):909. https://doi.org/10.3390/children8100909 .
  12. Polavarapu K, Vengalil S, Preethish-Kumar V, Arunachal G, Nashi S, Mohan D, Chawla T, Bardhan M, Nandeesh B, Gupta P, Gowda VK, Lochmüller H, Nalini A. Recessive VAMP1 mutations associated with severe congenital myasthenic syndromes - A recognizable clinical phenotype.Eur J Paediatr Neurol. 2021;31:54-60.PMID: 33631708 .
  13. Sanga S, Ghosh A, Kumar K, Polavarapu K, Preethish-Kumar V, Vengalil S, Nashi S, Bardhan M, Arunachal G, Raju S, Gayathri N, Biswas NK, Chakrabarti S, Nalini A, Roy S, Acharya M. Whole Exome Analyses of Congenital Muscular Dystrophy and Congenital Myopathy Patients from India Reveal a Wide Spectrum of Known and Novel Mutations. Eur J Neurol. 2020.PMID:33124102 .
  14. Bardhan, M., Dogra, H., & Samanta, D. (2020). Neonatal Myasthenia Gravis. In StatPearls. StatPearls Publishing.PMID: 32644361.
  15. Aeddula, N. R., Bardhan, M., & Baradhi, K. M. (2020). Sickle Cell Nephropathy. In StatPearls. StatPearls Publishing.PMID: 30252273.
  16. Bardhan, M., Kaushik, R. (2020). Physiology, Complement Cascade. In StatPearls. StatPearls Publishing.PMID: 31855355.
  17. Rackimuthu S, Hasan MM, Bardhan M, Essar MY. COVID-19 vaccination strategies and policies in India: The need for further re-evaluation is a pressing priority. Int J Health Plann Manage. 2021 Sep 12. doi: 10.1002/hpm.3321. Epub ahead of print. PMID: 34510541.
  18. Yousaf A, Khan FMA, Hasan MM, Ullah I, Bardhan M. Dengue, measles, and COVID-19: A threefold challenge to public health security in Pakistan. Ethics Med Public Health. 2021 Dec;19:100704. doi: 10.1016/j.jemep.2021.100704. Epub 2021 Jul 2. PMID: 34230890; PMCID: PMC8249682.
  19. Beijer D, Polavarapu K, Preethish-Kumar V, Bardhan M, Dohrn MF, Rebelo A, Züchner S, Nalini A. [CASE REPORT] Homozygous N-terminal missense variant in PLEKHG5 associated with intermediate CMT: a case report. J Neuromuscul Dis. 2021 Dec 5. doi: 10.3233/JND-210716. Epub ahead of print. PMID: 34897098.
  20. Chawla T, Preethish-Kumar V, Polavarapu K, Vengalil S, Bardhan M, Puri R, Verma J, Christopher R, Supriya M, Nashi S, Prasad C, Nadeesh B, Nalini A. Late Onset Pompe Disease with Novel Mutations and Atypical Phenotypes. J Neuromuscul Dis. 2021 Nov 30. doi: 10.3233/JND-210728. Epub ahead of print. PMID: 34864681.
  21. Sarkar MA, Ozair A, Singh KK, Subash NR, Bardhan M, Khulbe Y. SARS-CoV-2 Vaccination in India: Considerations of Hesitancy and Bioethics in Global Health. Annals of Global Health. 2021; 87(1): 124, 1–11. DOI: https://doi.org/10.5334/aogh.3530   .
  22. Ganaraja VH, Polavarapu K, Bardhan M, Preethish-Kumar V, Leena S, Anjanappa RM, et al. Disease Progression and Mutation Pattern in a Large Cohort of LGMD R1/LGMD 2A Patients from India. Glob Med Genet [Internet]. 09.11.2021. 2021 Nov 9;(EFirst). Available from: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736567 .