ICMR-National Institute of Cholera and Enteric Diseases

आई सी एम आर - राष्ट्रीय कॉलरा और आंत्र रोग संस्थान

Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
WHO Collaborating Centre For Research and Training On Diarrhoeal Diseases

NICED : Scientists

Dr. Alok Kumar Chakrabarti

Dr. Alok Kumar Chakrabarti

General Information
Name Dr. Alok Kumar Chakrabarti
Designation Scientist E
Date of joining ICMR 18th September 2006
Date of joining present post 1 September 2015
Discipline Virology, Molecular Biology, Bacteriophage
Division Virology
Specialization Virology
Email : chakrabarti.alok@icmr.gov.in , aloke8@yahoo.com
Academic Qualification  
Graduation B.Sc. University of Calcutta
Post Graduation M.Sc. University of Calcutta
Doctoral Ph.D. University of Calcutta


Professional Experience

After receiving M.Sc degree from University of Calcutta he joined as a junior research fellow at the National Institute of Cholera and Enteric Diseases. His research work on Vibrio cholerae O139 bacteriophages resulted in the development of a phage typing scheme for the identification and discrimination of highly virulent Vibrio cholerae O139 which is in routine use for nationwide screening of phage types of Vibrio cholerae O139. After completion of his PhD work, he moved to USA as a post-doctoral researcher where he gained expertise on virology. He worked on generation of recombinant influenza viruses to use influenza virus as a vector for gene transfer at UCLA Los Angeles. At UTMB, Galveston he performed research on replication of HIV-1. Afterwards he joined National Institute of virology, Pune as a regular faculty and worked on influenza viruses. Consequently he became in charge of Microarray Division at the National Institute of Virology. His research at NIV, Pune on molecular diagnostics of influenza contributed largely in management of bird flu outbreak in India. He developed reverse genetics modified vaccine strain for the highly pathogenic H5N1 influenza A viruses in collaboration with CDC, Atlanta, USA. His work on host influenza virus interactions revealed that delicate differences in the ability to induce specific host responses like apoptotic mechanism and immune responses make the highly pathogenic viruses (H5N1) more virulent. His work also attributed the high transmissibility of pH1N1 virus in the year 2009-2010 to its better subversion of host immune responses compared to the seasonal influenza viruses. Besides research and training Dr Chakrabarti also worked as a faculty for teaching MSc Virology at National Institute of Virology, Pune University for 10 years and also worked as invited faculty for the Department of Biotechnology at Pune University. Other than working for many institutional committees at NIV, he was also the in-charge of NIV library as an additional charge.

He joined NICED as Scientist in July, 2016 and working on respiratory viruses.His research involves viral diagnostics and host-virus interactions. Here at ICMR-NICED he is also involved in phage typing of V.cholerae O1 biotype ElTor strains.

Research Interests

His field of research interest includes work on respiratory viruses, as well as host-pathogen interactions. A major focus of his research is on influenza viruseswhich are one of the globally important human pathogens and a leading public health risk problem. Emergence of highly pathogenic avian influenza (HPAI) strains and pandemic H1N1 indicated a persistent need to work on influenza viruses to understand the pathogenesis of influenza A and development of vaccines and therapies. He is working on investigating the molecular pathogenesis and biology of influenza viruses. Phage typing of Vibrio cholerae is an ongoing activity of ICMR-NICED. He is working in pahge typing of V.cholerae and characterization of cholera bacteriophages.

Membership of Association

The Indian Science Congress Association


  • Prof A K Mukherjee Memorial Gold Medal, 1993
  • Junior Research Fellowship from Indian Council of Medical Research
  • Senior Research Fellowship Indian Council of Medical Research


  • Mr Partha Pratim Mondal, JRF
  • Mr. Devendra Nath Tewari, JRF

Travel to foreign countries to attend conference/meetings

The Indian Science Congress Association

  • As per the invitation form the organizer committee Dr. Chakrabarti attended a conference entitled "Alternative Approaches to Combatting Anti-Microbial Resistance (AMR)" in Almaty, Kazakhstan between April 18-19, 2019 and delivered a talk on "Use of bacteriophages in typing of Vibrio cholerae strains in India"


  1. Hospital-Based Surveillance for Maternal Health(1994-1995)
  2. Intervention Study, Phase II(Newborn Care)(1994-1995)
  3. District Project(RCH)(1994-1995)
  4.  A Study of Short Term Morbidity & Mortality Following Female Sterilization (1994-1996)
  5. Task-force Study on Hypertensive Disorders of Pregnancy / Eclampsia(1994-1995)
  6. A Multicentric Randomised Comparative clinical trial with 200 mg. RU-486(Mifepristone) followed by 5 mg. 9-Methylene PGE-2 Gel or 600 mg. PGE-1 for Termination of Early Pregnancy(1994-1996)
  7. Expanding Contraceptive Choices Available through Cafeteria approach(1995-1997)
  8. Expansion of Phase III Clinical Trial of Norplant 1(6 Capsules) through Cafeteria Approach(1995-2002)
  9. Modified District Project( Integrated Reproductive Health care)(1995-1999)
  10. Randomised Clinical Trial for Management of Eclampsia with Lytic Cocktail, Diazepam, and Magnesium Sulphate Regimen (1997-1998)
  11. A Study on Caesarian Section in Tertiary Hospitals (1997-1998)
  12. Feasibility Study of Using Pregnancy Detection Kits at Urban
  13. Slum Level( 1998-2000)
  14. Estimation of Wastage Factor for Oral Polio Vaccine (OPV) during
  15. Pulse Polio Immunization (PPI) Campaign (17.01.1999)
  16. Coverage Evaluation Survey on Immunization (July 1999 -August 1999)
  17. A Study of Management Practices of Meconium Stained Amniotic
  18. Fluid (MSAF) and Meconium Aspiration Syndrome (MAS) Cases -- an Explorative Study ( 1999-2000)
  19. A Study of Knowledge, Attitude & Practices (KAP) of Emergency Contraception among Women of Reproductive Age Group Including Adolescent Girls and providers ( 1999-2000)
  20. Pre-Programmed Introduction Study with IUD and Levonorgestrel in
  21. Women Seeking Emergency Contraception through a Cafeteria
  22. Approach (2001-2002) Pilot Study on Emergency Contraception with
  23. Cu-T 200-B and 0.75 mg. Levonorgestrel ( 2 Doses) ( 2001-2003)
  24. Evaluation of Sensitivity & Specificity of the Pregnancy
  25. Detection KIts, Ultrasound as Standard for Confirmation of
  26. Pregnancy ( 2001-2003)
  27. A Multicentre Open Study with Desogestrel Only Contraceptive
  28. Pill ( Cerazette) to Assess the Efficacy, Bleeding Pattern, and
  29. Acceptability in Indian Women ( in Collaboration with Infar India Ltd.) ( 2001-2002)
  30. Hospital-Based Surveillance of on childhood morbidity and mortality ( 2004-2005)
  31. Multicentric Phase III Clinical Trial with Subdermal Single-Rod
  32. Contraceptive Implant -- Implanon ( 2004-2016)
  33. Previous Caesarian Section: Management and Outcome (2004-2005)
  34. A Study on Database of Obstetric Fistula ( 2005-2007)
  35. Study on Management and Outcome of Eclampsia ( Baseline
  36. Information ( 2007)
  37. Low Dose Versus Standard Dose Magnesium Sulphate Regimen for
  38. Management of Eclampsia -- A Randomised Controlled Trial (2007-2009)
  39. Task Force Study -- " Prevalence of Infertility in India ".( 2009-2013)
  40. Comparative Acceptability of Male Condom and FC 2 Female Condom in Young Indian Couples Seeking Contraceptive Options (2009-2010)
  41. A Simple Behavioral Intervention to Reduce Episiotomy Rates ( 1 Month Database) (2009)
  42. A Simple Behavioral Intervention to Reduce Episiotomy Rates ( 1 Year Database) (2009-2010)
  43. Phase IV Multicentric study with Centchroman ( 2009-2010)
  44. Hospital-Based Surveillance of Female Genital Fistula -- An ICMR
  45. Task Force Project ( 2011-2013)
  46. Hysterectomy Profile in Tertiary Care Public Hospitals: Indications, Route of Surgery and Complications - a Multicentric Study ( 2019-2021)
  47. A Task Force Multicentric Study on Teenage Pregnancy and Its Outcome (2011-2017)
  48. Evaluation of Progesterone Vaginal Ring (PVR ) as a New Contraceptive Option in India ( 2011-2017)
  49. Baseline Survey for the Last Three Years, on Male Infertility Cases in the Infertility Clinic of the Dept. of G & O and Uro Surgery OPD, R. G. Kar Medical College, Kolkata ((2015)
  50. Survey on Management of Uterine Fibroids,in R. G. Kar Medical College Kolkata (2015)
  51. Pilot Study on Respectful Maternity Care( RMC), ICMR Task Force Study ( May-June,2017)
  52. Baseline Survey ( Retrospective) of Birth Defects in R. G. Kar Medical College, Kolkata ( From January 2016-December,2016) (May 2017)
  53. Retrospective Survey on Types of Delivery in R. G. Kar Medical College, Kolkata ( From January 2017- December 2017 ) ( June 2018)
  54. Retrospective Baseline Survey of Acceptance Rate of PP IUCD vs Centchroman in the Dept. of G & O, in R. G. Kar Medical College, Kolkata: Year, 2017 ( July 2018)
  55. Respectful Maternity Care Initiative - ICMR Task Force Study in Collaboration with Center for Catalyzing change / White Ribbon Alliance India (WRAI) ( 2017-2021)
  56. Health Account Scheme (HAS) Operational Evaluation - in the Districts( 2018-2021)
  57. Assisted Vaginal Delivery (AVD) at Tertiary Level Hospitals: Indications and Outcome ( 2019-2021)
  58. Hysterectomy Profile in Tertiary Care Public Hospitals: Indications, Route of Surgery and Complications - a Multicentric Study ( 2019-2021)
  59. Maternal Near Miss Review ( MNM-R) and Corrective Measures at Selected Tertiary hospitals in India ( with NIRRH, Mumbai) ( 2020-2021)
  60. HGCO-19 Clinical Trial: A Multicentric Double-Blind Study with Covishield vs mRNA Vaccines at ICMR- NICED, Kolkata ( December 2021 -Till Date, March 2022)





  1. Tewari DN, Chakrabarti AK, Dutta S (2021) Prospect of Ion Channel Inhibitors and Cholesterol Lowering Drugs to Combat COVID-19. J Emerg Dis Virol 6(2): dx.doi.org/10.16966/2473-1846.162
  2. Sarkar A, Chakrabarti AK, Dutta S. Covid-19 Infection in India: A Comparative Analysis of the Second Wave with the First Wave. Pathogens. 2021 Sep 21;10(9):1222.
  3. Viswanathan R, Chakrabarty A, Basu S. Active support after natural disasters: a review of a microbiologist's role. Trans R Soc Trop Med Hyg. 2021; 115(1):110-116.
  4. Krishnan A, Dar L, Amarchand R, Prabhakaran AO, Kumar R, Rajkumar P, Kanungo S, Bhardwaj SD, Choudekar A, Potdar V, Chakrabarti AK, Kumar CG, Parameswaran GG, Dhakad S, Manna B, Choudhary A, Lafond KE, Azziz-Baumgartner E, Saha S. Cohort profile: Indian Network of Population-Based Surveillance Platforms for Influenza and Other Respiratory Viruses among the Elderly (INSPIRE). BMJ Open. 2021 Oct 7;11(10):e052473.


  1. Biswas A, Bhattacharjee U, Chakrabarti AK, Tewari DN, Banu H, Dutta S. Emergence of Novel Coronavirus and COVID-19: whether to stay or die out?. Crit Rev Microbiol. 2020Mar; 46(2):182-193. Pubmed
  2. Chakrabarti AK, Biswas A, Tewari DN, Mondal PP, Dutta S. Phage types of Vibrio cholerae 01 biotype ELtor strains isolated from India during 2012 -2017. J Global Infect Dis 2020; 12(2):94-100.


  1. Biswas A, Chakrabarti AK, Dutta S. Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 9:1-16. doi: 10.1080/08830185.2019.1685990. [Epub ahead of print]   Pubmed


  1. Pasricha G, Mukherjee S, Chakrabarti AK. Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells. Adv Virol. 2018 Dec 31;2018:5057184.  Pubmed


  1. Sarkar S, Das M, Bhowmick TS, Koley H, Atterbury R, Chakrabarti AK, Sarkar BL. Isolation and Characterization of Novel Broad Host Range Bacteriophages of Vibrio cholerae O1 from Bengal. J Glob Infect Dis. 2018 Apr-Jun;10(2):84-88. Pubmed
  2. Patil S, Shetty P, Kulkarni R D, Ajantha GS, Kalabhavi A, Patil D, Hosamani M, Jain P, Chakraborti A.K. and Shubhada C. Antibiogram and Serotyping of Vibrio cholerae O1 Isolates from a Tertiary Care Centre in South India. J Pure Applied Microbiol 2017 Jun; 11:2 1039-1043


  1. Sarkar BL, Chakrabarti AK, Sarkar S and Dutta S. Vibriophage and Cholera Disease. Indian J.Applied.Microbiol. 2016; 19(2): 9-20.


  1. Muthulakshmi, S., Chakrabarti, AK.and Mukherjee, S. Gene expression profile of high-fat diet-fed C57BL/6J mice: in search of potential role of azeliac acid. J PhysiolBiochem 71:1(2015) 29-42


  1. Pasricha, G., Mukherjee, S. and Chakrabarti, AK*. Comprehensive sequence analysis of HA protein of H7 subtype avian influenza viruses: an emphasis on mutations in novel H7N9 viruses. Future Virol 9 (2014) 251-273.


  1. Mukherjee, S. Vipat, VC. andChakrabarti, AK*. Infection with Influenza A viruses causes changes in promoter DNA methylation of inflammatory genes. Influenza Other Respi Viruses 7:6(2013) 979-86.
  2. Chakrabarti, AK*.andPasricha, G. An insight into the PB1F2 protein and it multifunctional role in enhancing the pathogenicity of the Influenza A viruses. Virology. 440:2 (2013) 97-104.
  3. Pasricha, G., Mishra, AC., and Chakrabarti, AK*. Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the Influenza A virus subtypes responsible for the 20th century pandemics. Influenza Other Respi Viruses. 7:1(2013) 497-505


  1. Mukherjee, S. and Chakrabarti, AK*.Impact of Microarray Technology in Influenza Virus Research and Diagnostics. J Proteomics Bioinform S6 (2012), 002
  2. Mukherjee, S., Majumdar, S., Vipat, VC., Mishra, AC., and Chakrabarti, AK.* Non Structural protein of Avian Influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing Apoptosis in host cells. Virol J 6:9(2012)149


  1. Mukherjee, S., Vipat, VC., Mishra, AC., Pawar, S.D. and Chakrabarti, AK.* Pandemic (H1N1) 2009 influenza virus induces weaker host Immune Responses in vitro a possible mechanism of high transmissibility. Virol J 8:7 (2011) 140

  2. Study on 'Wastage Factors of Vaccines in UIP' - presentation of the paper in the ISMS conference'2011.


  1. Chakrabarti, AK.*, Vipat, VC., Mukherjee, S., Singh, R., Pawar, SD. and Mishra, AC. Host gene expression profiling in influenza a virus-infected lung epithelial (A549) cells a comparative analysis between highly pathogenic and modified H5N1 virus. Virol J 7 (2010) 219.
  2. Pawar, S., Chakrabarti, A., Cherian, S., Pande, S., Nanaware, M., Raut, S., Pal, B., Jadhav, S., Kode, S., Koratkar, S., Thite, V. and Mishra, V. A novel avian infleunza A (H11N1) virus from wild aquatic bird revealing a Eurasian -Amricana genetic reassortment. Virus Genes 4:1 (2010) 14-22


  1. Chakrabarti, AK., Pawar, SD., Cherian, SS., Koratkar, S., Jadhav, SM., Pal, B., Raut, S., Thite, V., Kode, SS., Mullick, J. and Mishra, AC. Characterization of the influenza A H5N1 viruses of the 2008-09 outbreaks in India reveals a third introduction and possible endemicity in the region. PloS One.4 (2009) e7846.
  2. Mishra, AC., Cherian, SS., Chakrabarti, AK.,Pawar, SD., Jadhav, SM., Pal, B., Raut, S., Koratkar, S. and Kode, SS. A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India.Virol J 6(2009) 26.
  3. Pawar, SD., Pande, S., Jamgaonkar, A., Koratkar, S., Pal, B., Raut, S., Nanaware, M., Ray, K., Chakrabarti, AK. andKode, S. Avian influenza surveillance in wild migratory, resident domestic birds and in poultry in Maharashtra and manipur, India, during avian migratory season 2006-07. CurrSci 97 (2009) 550.


  1. Booklet on Emergency Contraception by Dr. A. Mondal, Dr. A.K. Chakraborty, Dr. C. Bose


  1. Publication in the book of WHO conference  Consortium on National Consensus for Emergency Contraception, jointly organized by W.H.O., MOHFW & ICMR, New Delhi, January 2001  - Providers Concept of Emergency Contraception by Dr. A.K.Mondal, Dr. A.K. Chakraborty, Dr. P.K. Kalsar, Dr.C. Bose, Dr. A.Kar et al, R.G.Kar Medical College, Kolkata, pg 96 (1.6.7)


  1. Article  - Preterm Labor and medicolegal problems in the book, ''Preterm Labor'' by JAYPEE Brothers (an ISOPARB publication) in 1998 (pg no 221  - 224).

  2. Article - Thyroid disorders in pregnancy and preterm labor in the book, ''Preterm Labor'' by JAYPEE Brothers (an ISOPARB publication) in 1998 (pg no 79 - 81).


  1. Article  - Counseling in medical practice with special reference to Obstetrics & Gynaecology in the book, ''Medicolegal aspects in Obst. & Gynae. By JAYPEE Brothers (a FOGSI publication) in 1997 (pg 185  - 194).