National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India

NICED : Scientists

Dr. Sulagna Basu

Dr. Sulagna Basu

Sulagna Basu is a Scientist at the National Institute of Cholera and Enteric Diseases, Kolkata. She joined the Institute in 2006. Her current research focuses on the colonization of the neonatal gut with Gram negative bacilli and bacterial resistance to antimicrobial agents in neonatal infections. Her laboratory has identified some of the currently widely disseminated antibiotic resistance determinants in bacteria causing neonatal infections.

Sulagna Basu graduated from the University of Calcutta with B.Sc. in Chemistry. She earned her M.Sc. from the Department of Biochemistry, University of Calcutta. Dr. Basu received her Ph.D in 2003 from The Post Graduate Institute of Medical Education and Research, Chandigarh . During this period her research revolved around the purification and characterization of a lectin from Enteroaggregative Escherichia coli . She received the ACBICON 2003 award for the work on Enteroaggregative E.coli.

General Information
Name : Dr. Sulagna Basu
Designation : Scientist E
Educational Qualification : M.Sc., Ph.D.
Date of joining ICMR : 19th January 2006
Date of joining present post : 1st September 2014
Discipline: Microbiology
Division : Bacteriology
Specialization : Microbiology
Email : sulagnabasu@gmail.com , supabasu@yahoo.co.in  ,basus.niced@gov.in
Academic Qualification : M.Sc., Ph.D.
Graduation : B.Sc in Chemistry , University of Calcutta
Post-Graduation : M.Sc in Biochemistry University of Calcutta
Doctoral : PhD, Post Graduate Institute of Medical Education and Research, Chandigarh

Profile

Research Experience

Dr. Basu received her Ph.D. in 2003 from The Post Graduate Institute of Medical Education and Research, Chandigarh for her thesis involving the isolation and characterization of a biologically active lectin from enteroaggregative E.coli. She was a Senior Demonstrator at the Institute from 2003-2005. During this period she studied the plasmid mediated virulence factors of enteroaggregative E.coli and their role in the disease process.

Sulagna Basu joined National Institute of Cholera and Enteric Diseases, Kolkata as a Scientist in 2006. Her current research focuses on bacterial resistance to antimicrobial agents in neonatal infections and the colonization of the neonatal gut with Gram negative bacilli. Her laboratory has identified some of the currently widely disseminated antibiotic resistance determinants in bacteria causing neonatal infections.Studies from her laboratory on extended spectrum β-lactamases and carbapenemases have shed light on the prevalence, genetic diversity of these enzymes and their modes of transmission in the context of neonatal infections.
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Research Interests

The current research interest in our laboratory involves drug resistance in Gram negative bacilli that cause neonatal infections and studies on colonization of the neonatal gut with Gram negative bacilli.
We primarily study the highly antibiotic-resistant Gram-negative bacteria Acinetobacterbaumannii, Klebsiellapneumoniae, and Escherichia coli. The main focus of the studies is on carbapenemases and other lactamases. Along with transmissible modes of resistance,role of multi-drug efflux pumpsare also evaluated. Additionally, we are exploring the mechanisms related topathogenesis in Acinetobacterbaumanniiand Klebsiellapneumoniae.
 

Projects

Extramural

  • Gut derived sepsis in neonates: the role of extended spectrum β lactamase (ESBL) producing E. coli and Klebsiella funded by Okayama University, Japan. (Principal Investigator).
  • Gastric aspirate: an indicator of sepsis' DST West Bengal (Principal Investigator) 2007-2009
  • Effect of Probiotics on carriage of Extended Spectrum Beta Lactamase producing Enterobacteriacae in neonatal gut: A randomized controlled trial at a Tertiary care Neonatal Intensive Care Unit., DBT (Coinvestigator) 2011-2014.
  • Cefotaximases in E.coli isolated from hospitalized neonates, DST West Bengal 2010-2012 (Principal Investigator)
  • Acquired mechanisms of quinolone resistance in carbapenem-resistant Enterobacteriacae : relevance in neonatal healthcare. DST West Bengal, 2015-2018 (Principal Investigator)
  • Assessing drug resistance in Enterobactericae causing neonatal sepsis in North-East India: resistance mechanisms and transmission, ICMR, 2015-2018 (Co-Principal Investigator)
  • Burden of Antibiotic Resistance in Neonates from Developing Societies, (BARNARDS), Bill and Melinda Gates Project through Cardiff University,May 2017 to June 2018( Principal Investigator, India site)
     

Intramural

  • The role of gut microflora in neonatal sepsis with special reference to gram negative rods (Principal Investigator)
  • Intestinal colonization by carbapenem-resistant Escherichia coli in neonates admitted to a tertiary care hospital (Principal Investigator)
  • Studies on Serine Protease Autotransporters of Enterobacteriacae(SPATEs) from clinical isolates of Escherichia coli causing neonatal septicaemia(Coinvestigator)
  • Mobile genetic elements in Enterobacteriacae: a focus on β-lactam resistance
     

Students:( Presently working):

JRF:

  • Amrita Bhattacharjee

SRF:

  • Sharmi Naha
  • Subhankar Mukherjee
  • Shravani Mitra

RA :

  • Dr. Subhashree Roy

Ph.D. awarded/ submitted

  • Parijat Das, awarded in 2013 from Jadavpur University
  • Subhasree Roy awarded in 2013 from University of Calcutta
  • Saswati Datta awarded in 2017from University of Calcutta
  • Somdatta Chatterjee submittedto University of Calcutta
     

Awards

  • ACBICON-2003 (Association of Clinical Biochemists of India) Award
  • Shanti Bhakta Memorial Award (University of Calcutta)
  • Selected as Young Investigator by Yakult India Microbiota and Probiotic Science Foundation at the Symposium on Probiotics in Prevention of Lifestyle Disorders. Bengaluru, India. 15th - 16th December 2012.

Miscellaneous

  • Acted as reviewer for Lancet Infectious Diseases, Antimicrobial agents and Chemotherapy, Journal of Antimicrobial Chemotherapy, Paediatrics, Infection and Immunity, Frontiers in Microbiology, PLOS one, Journal of Global Microbial Resistance, Microbial Drug Resistance, Environmental Science & Technology, Journal of Medical Microbiology, Indian Journal of Medical Research, BMC Microbiology, New Microbes and Infection.
  • Participated in formulating the Guidelines for breast milk storing and dispensing for babies admitted at health facilities as an expert. This is an initiative of the Child Health Division , Ministry of Health and Family Welfare , Govt. Of India.

Memberships

  • Association of Microbiologists of India
  • Society of Biological Chemists (India).
  • Indian Science Congress Association

Travel to foreign countries to attend conference/meeting :

  • Presentation at 16th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim, Bangladesh, February 9-14, 2014.
  • Presentation at 48th United States-Japan CMSP Conference on Cholera and Bacterial Enteric Diseases,Bangladesh, February 9-14, 2014

Publications

2017

  1. Chatterjee S, Mondal A, Mitra S, Basu S. Acinetobacter baumannii transfers the blaNDM-1 gene via outer membrane vesicles. J Antimicrob Chemother. 2017 Aug 1;72(8):2201-2207  Pubmed

  2. 2. Datta S, Mitra S, Chattopadhyay P, Som T, Mukherjee S, Basu S. Spread and exchange of bla (NDM-1) in hospitalized neonates: role of mobilizable genetic elements. Eur J Clin Microbiol Infect Dis. 2017 Feb;36(2):255-265. Pubmed

2016

  1. Chatterjee S, Datta S, Roy S, Ramanan L, Saha A, Viswanathan R, Som T and Basu S.2016. Carbapenem resistance in Acinetobacter baumannii and other Acinetobacter spp. causing neonatal sepsis: focus on NDM-1 and its linkage to ISAba125. Front Microbiol. doi: 10.3389/fmicb. 2016.01126.
  2. Banerjee, A, Ghosh MK, Karak K, Basu S, Mukhopadhyay BB, Mallik S, Saha B. 2016. Lower respiratory tract infection in Kolkata and multidrug resistant pathogen- with a focus on carbapenem resistant organism. Int J Contemporary Med Res; 3:873-880.016

2015

  1. Datta, S., Chatterjee, S., Mitra, S., and Basu, S. 2015. A reliable phenotypic assay for detection of ESBLs and AmpCs in MBL-producing gram-negative bacteria with the use of aminophenylboronic acid, dipicolinic acid and cloxacillin. Journal of Microbiological Methods. 115:100-103 Pubmed
  2. Basu, S. 2015. Neonatal sepsis- the gut connection. Eur J ClinMicrobiol Infect Dis. 34:215-222 Pubmed
  3. Roy, S., Datta, S., Das, P., Gaind, R., Pal, T., Tapader, R., Mukherjee, S., Basu, S. 2015. Insight into neonatal septicaemic Escherichia coli from India with respect to phylogroups, serotypes, virulence, extended-spectrum-β-lactamases and association of ST131 clonal group. Epidemiol Infect.143:3266-3276. Pubmed

2014

  1. Datta, S., Roy, S., Chatterjee, S., Saha, A., Sen, B., Som, T., and Basu, S. 2014. A five-year experience of carbapenem resistance in Enterobacteriaceae causing neonatal septicemia: predominance of NDM-1. PLoS One.9(11):e112101 Pubmed
  2. Tapader,R., Chatterjee, S., Singh, A. K., Dayma, P., Haldar, S., Pal, A., Basu, S. 2014 .The high prevalence of serine protease autotransporters of Enterobacteriaceae (SPATEs) in Escherichia coli causing neonatal septicemia. European Journal of Clinical Microbiology and Infectious Diseases33:2015-2024. Pubmed
  3. Datta, S., Mitra, S., Viswanathan, R., Saha, A. and Basu, S. 2014. Novel plasmid-mediated ß-lactamases (SHV-167 and ACT-16) associated with New Delhi Metallo-ß-lactamase-1 harbouring isolates from neonates in India. J. Med. Microbiol. 63:480-482. Pubmed
  4. Viswanathan, R., Singh, AK.,Basu, S., Chatterjee, S., Roy, S. and Isaacs, D. 2014. Multidrug-resistant, non-fermenting, gram-negative bacilli in neonatal sepsis in Kolkata, India: a 4-year study. Paediatrics and International Child Health 34: 56-59 Pubmed

2013

  1. Das, P., Singh, A.K., Mukherjee, S., Rajendran, K., Saha, D.R., Koley, H., Basu S. 2013. Composition of Escherichia coli population in the neonatal gut: phylogroups and virulence determinants. J. Med. Microbiol. 62: 1680-1687. Pubmed
  2. Roy, S., Rajendran, K., Mukherjee, S., Schneiders, T., Niyogi, S.K., and Basu, S. 2013. Prevalence of ST131 virulence-associated strains among CTX-M-producing Escherichia coli in the gut of hospitalized neonates in India. Diagn. Microbiol. Infect. Dis. 77: 158-159. Pubmed
  3. Choudhury, SR., Mandal, A., Ghosh, M., Basu, S., Chakravorty, D. and Goswami, A. 2013. Investigation of Antimicrobial Physiology of Orthorhombic and Monoclinic Nanoallotropes of Sulfur at the Interface of Transcriptome and Metabolome. Applied Microbiology and Biotechnology, 97: 5965-5978.
  4. Roy, S., Datta, S., Viswanathan, R., Singh, A.K., and Basu, S. 2013. Tigecycline susceptibility in Klebsiella pneumoniae and Escherichia coli causing neonatal septicaemia (2007-2010) and role of efflux pump in tigecycline nonsusceptibility', J. Antimicrob. Chemother., 68: 1036-1042. Pubmed
  5. Jain, P., Roy, S., Viswanathan, R., Basu, S., Singh, AK., and Dutta, S. 2013. Concurrent and transferable resistance to higher generation cephalosporins, monobactam and fluoroquinolone in Salmonella enterica serovar Worthington blood isolate from a neonate in Kolkata, India, Int. J. Antimicrob. Agents. 41: 494-5 Pubmed
  6. Roy, S., Gaind, R., Mohanty, S., Datta, S., Singh, AK. and Basu, S.2013. Neonatal septicaemia caused by diverse clones of Klebsiella pneumoniae and Escherichia coli harboring blaCTX-M-15 . Indian J. Med. Res. 137: 791-799

2012

  1. Roy Choudhury, S., Roy, S., Goswami, A., and Basu, S. 2012. Polyethylene glycol-stabilized sulfur nanoparticles: an effective antimicrobial agent against multidrug-resistant bacteria, J of Antimicrob Chemother, 67: 1134-1137 Pubmed
  2. Viswanathan, R., Singh, AK., Basu, S., Chatterjee, S., Sardar, S. and Isaacs, D. 2012. Multi-drug resistant Gram negative bacilli causing early neonatal sepsis in India , Arch Dis Child Fetal Neonatal Ed, 97: F-182-F187 Pubmed
  3. Viswanathan, R., Singh, AK., Ghosh, C., Dasgupta, S., Mukherjee, S. and Basu, S. 2012. Profile of neonatal septicaemia at a district level sick newborn care unit. J Health Popul Nutr, 30: 41-48. Pubmed
  4. Sinha, A., SenGupta, S., Ghosh, S., Basu, S., Sur, D., Kanungo, S., Mukhopadhyay, AK., Ramamurthy, T., Nagamani, K., Rao, MN. and Nandy, RK. 2012. Evaluation of a rapid dipstick test for identifying cholera cases during the outbreak. Indian J Med Res, 135: 523-528 Pubmed
  5. Viswanathan, R., Singh, AK., Ghosh, C., Mukherjee, S., Sardar, S. and Basu, S. 2012. Experience of setting up a microbiology service for rural facility based sick newborn care unit . Journal of Tropical Pediatrics, 58 : 80-81 Pubmed

2011

  1. Roy, S., Singh, AK., Viswanathan, R., Nandy, RK. and Basu, S. 2011. Transmission of imipenem resistance determinant during the course of an outbreak with NDM-1 Escherichia coli in a sick new born care unit. J. Antimicrob. Chemother. 66: 2773-2780 Pubmed
  2. Das, P., Singh, AK., Pal, T., Dasgupta, S., Ramamurthy, T. and Basu, S. 2011 Colonization of the gut with gram negative bacilli, its association with neonatal sepsis and its clinical relevance in a developing country. J. Med. Microbiol. 60: 1651-1660 Pubmed
  3. Roy, S., Mukherjee, S., Singh, AK. and Basu, S. 2011. CTX-M-9 group extended-spectrum ß-lactamases in neonatal stool isolates: emergence in India. Indian J. Med. Microbiol., 29: 305-308. Pubmed
  4. Roy, S., Viswanathan, R., Singh, AK., Das, P. and Basu, S. 2011. Sepsis in neonates due to imipenem-resistant Klebsiella pneumoniae producing NDM-1 in India, J. Antimicrob. Chemother., 66 : 1411-1413. Pubmed
  5. Viswanathan, R., Singh, A.K., Mukherjee, S., Mukherjee, R., Das, P. and Basu, S. 2011 An outbreak of neonatal sepsis presenting with exanthematous rash caused by Klebsiella pneumoniae. Epidemiology Infection 139 : 226-228. Pubmed
  6. Viswanathan, R., Singh, A. K., Mukherjee, S., Mukherjee, R., Das, P., and Basu, S. 2011. Aetiology and antimicrobial resistance of neonatal sepsis at a tertiary care centre in Eastern India: a 3 year study. Indian Journal of Pediatrics 78: 409-412. Pubmed
  7. Viswanathan, R., Singh, A. K , Ghosh, C. , Basu S., 2011 Stenotrophomonas maltophilia in early onset neonatal sepsis. Indian Pediatrics 48: 397-399 Pubmed

2010

  1. Basu, S., Singh, A. and Nair, G. B. 2010 Emerging Carbapenem Resistance in the Context of a New Metallo-ß-lactamase (NDM-1). National Medical Journal of India 23: 261-262. Pubmed
  2. Roy, S., Viswanathan, R., Singh, A., Das, P. and Basu, S. 2010 Gut colonization by multidrug and carbapenem resistant Acinetobacter baumannii in neonates. European Journal of Clinical Microbiology and Infectious Diseases 29: 1495- 1500. Pubmed
  3. Roy, S., S. Basu, S. Dasgupta, A. Singh, R. Viswanathan. 2010 Carbapenem resistance in Acinetobacter baumannii isolated from blood of neonates with sepsis. Indian Journal of Medical Microbiology, 28: 416-417. Pubmed

2009

  1. Basu, S., P. Das, S. Roy, S. De and A. Singh. 2009. Survey of gut colonization with Stenotrophomonas maltophilia among neonates. J. Hospital. Infect. 72:183-185. Pubmed

2005

  1. Verma, A., S. Basu, S. Ghosh, S. Majumdar and N. K Ganguly. 2005. The effect of type-1 fimbrial immunization on gut pathophysiological response in rats infected with Salmonella enterica subsp. enterica serovar Typhimurium. Mol. Cell Biochem. 273: 127-135. Pubmed

2004

  1. Basu, S., S. Ghosh, N. K. Ganguly and S. Majumdar. 2004. Biologically active lectin of Enterroaggregative E. coli. Biochimie. 86: 657-666. Pubmed

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