National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India

NICED : Scientists

Dr. Mamta Chawla Sarkar

Dr. Mamta Chawla Sarkar

Dr. Mamta Chawla-Sarkar joined as Scientist C in Division. of Virology, NICED, Kolkata in January 2006. Dr Chawla Sarkar gained her Master's in Zoology in 1992 from Calcutta University and acquired the degree of Ph.D from Bose Institute-Jadavpur University, Kolkata in 1999. She did her Post-doctoral research work as Research Associate for six years in the Center for drug discovery & development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland. The research project was on analysis of the genes involved in antitumor effects of Interferons and the mechanisms underlying IFN resistance in tumors of different histopathologies. In addition she was also involved in project on role of heme insertion in dimerization and activity of inducible nitric oxide synthetase and study the effect of heme binding inhibitors in modulating NOS activity in various pathological disorders. After joining Division of Virology at NICED, Dr Chawla-Sarkar has been involved in studying two viruses namely Influenza virus and Rotavirus. Her research focus involves strain surveillance, Host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets. As a scientist -in-charge for Influenza surveillance in NICED, Dr Chawla-Sarkar was responsible for providing laboratory support for states in Eastern India during A/H1N1 pandemic in 2009. In 2010, she was promoted to Scientist D (Assistant Director). In 2013, she was elected Fellow of the National academy of science in India (NASI). She was honored with "National Women Bioscientist Award" by Department of Biotechnology in 2013. She is currently working on four projects:

  1. Multisite monitoring of Influenza Virus strains in India.
  2. Analysis of the Rotavirus-host cell interaction: Study of role of Rotavirus encoded proteins and host cellular proteins during virus infection.
  3. Analysis of the Rotavirus-host cell interaction: Study of role of Rotavirus encoded proteins and host cellular proteins during virus infection.
  4. National Rotavirus Surveillance Network.

Dr. Chawla-Sarkar has trained number of students and project staff in various aspects of virus research. Six students have completed their Ph.D. program under her guidance and are now doing post doctoral training in USA and Europe. Currently six students are enrolled for Ph.D. under her guidance. She is the author of more than 65 research papers in the peer-reviewed international journals and two Book chapters in the area of Molecular biotechnology, Immunology, Biological Chemistry and Virology.

General Information
Name Dr. Mamta Chawla Sarkar
Designation Scientist E
Date of joining ICMR 09th January 2006
Date of joining present post: 1st September 2014
Discipline:  Virology, Molecular Biology
Division Virology
Specialization Virology, Molecular Biology
Email : chawlasarkar.m@icmr.gov.in
Academic Qualification M.Sc., Ph.D., FNASc
Graduation: BSc. Zoology (Hons), Calcutta University
Post Graduation : MSc. Zoology, Calcutta University
Doctoral Microbiology/Life Sciences, Jadavpur University
   

Profile

Research Experience

Dr. Mamta Chawla-Sarkar, Scientist E, Division of Virology, NICED-ICMR, Kolkata has more than 15 years of research experience in biomedical research. She worked on understanding the role of IFN as anti-cancer therapeutics and mechanisms which underly IFN resistance in subset of patients. In addition, a number of compounds were analyzed as anti-cancer therapeutics by her during her post-doctoral tenure in the Center for drug discovery & development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland (1999-2004). Since 2006, after joining ICMr-NICED, Dr. Chawla-Sarkar has been involved in studying both basic and public health aspects of Rotavirus (Enteric) and Influenza A virus (Respiratory), both of which cause significant morbidity worldwide. Her research focus involves strain surveillance, host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets. She was the coordinating scientist for ICMR’s National Rotavirus Surveillance Network and Influenza Surveillance for Eastern India. Dr. Chawla-Sarkar’s lab was responsible for providing laboratory support in West Bengal during A/H1N1 outbreaks in 2009, 2015 and 2017.

Research Interests

An estimated 200,000 deaths annually among children <5y worldwide are attributable to rotavirus (RV) each year, of which 30% occur in India.There has been substantial information on epidemiology, vaccine efficacy, genotypes of rotavirus, information about the molecular mechanism by which the virus subvert their hosts’ cellular immune response or the involvement of host proteins during infection is scanty.Thus the researchinterest of our lab involves strain surveillance, host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets.Studies on Rotavirus infection using microarray and proteomics techniques have led for first time to the identification of a number of cellular genes which positively aid virus replication. Inhibiting these cellular genes, results in 2-4 log reduction in viral titers, suggesting that these can be potential drug targets. In addition, to understand rotavirus pathogenesis, our lab is interested in understanding the role of virus encoded non-structural proteins in modulating host innate immune responses during different stages of virus replication. 

Membership/ Fellow of Professional Societies/ Associations

  1. Member of Indian Science Congress
  2. Member of Society of Biological Chemists
  3. Member of Indian Virological society
  4. Fellow of the National Academy Of Science in India ( NASI)

Awards

  1. Fellowship of National Academy of Science in India (FNASc) in 2013
  2. National Women Bioscientist Award (Young Category) by Dept of Biotechnology (DBT) in 2013

Projects

Extramural

  1. Multisite Monitoring of Influenza virus strains Surveillance in India (ICMR/CDC) : 2009-2014 (5year)
  2. Analysis of rotaviruses and their interactions with the host: A Viral Proteomics Approach (Okayama Univ/AMED:): 2010-2015 (5year)
  3. National Rotavirus Surveillance Network - Referral Lab Eastern India (ICMR): 2013-2016 (4year)
  4. Studies on viral and cellular determinants of rotavirus infections( DBT): 2015-ongoing (5year)
  5. Enhancing Bio-risk Mitigation Awareness in Public Health Community and Creating Laboratory Network for Enhanced Diagnostic Capabilities to Deal With Surveillance and Outbreaks of High-Risk Group Viral Pathogens Causing Respiratory Infections( CDC USA and NIV): 2016-2017 (1year)
  6. Screening of small molecules with antiviral activity as adjunct therapy for viral diarrhea( OkayamaUniv/AMED): 2015- ongoing ( 5year)
  7. An approach to identify the environmental drivers modulating rotavirus seasonality (ICMR) : 2017-ongoing (3year)

Intramural

  1. To analyze Host-Rotavirus Interactions: Pivotal role of the host proteins during virus replication and pathogenesis. 2013- ongoing (5 year))

Students presently working in the lab

  • JRF:
    • Mahadeb Pal
    • Rakesh Sarkar
  • SRF:
    • Arpita Mukherjee
    • UpayanPatra
    • Urbi Mukherjee
    • Anindita Banerjee
       

Travel to foreign countries to attend conference/ meetings

  1. "Japan India Bilateral Meeting on the collaborative research projects" and the "International Seminar on Infectious Diseases" at the National Institute of Infectious Diseases (NIID), Tokyo during Jan 25th-27th 2015. Oral presentation on Rotavirus surveillance and "Full genome characterizationof unusual rotavirus group A genotypes G10P[14] and G12P[11] in hospitalized children with acute gastroenteritis in Kolkata, India"
  2. 17th International Conference on Emerging Infectious Diseases (EID) meeting at Taipei, Taiwan 25-29 Jan 2015. Oral presentation entitled "Calmodulin Positively Regulates Rotavirus Infection by Modulating Host Cell Cycle Progression".
  3. 17th International Conference on Emerging Infectious Diseases (EID) meeting at Taipei, Taiwan 25-29 Jan 2015. Oral presentation entitled "Rotavirus modulates activity of antiviral protein Viperin to combat host induced IFN responses during infection".
  4. Asian-African Research Forum on Emerging and Reemerging Infections, Sendai,Japan, 20-22 Jan 2014.Oral Presentation entitled "Multiple functions of Rotavirus encoded Non-structural proteins (NSPs) for Combating host Responses during Infection".
  5. 5th European Rotavirus biology Meeting Valencia, Spain, 6-9 October 2013. Oral presentation entitled "Multiple Strategies adopted by Rotavirus encoded Non- structural protein (NSP1) for evasion of cellular responses".
  6. 5th European Rotavirus biology Meeting Valencia,Spain, 6-9 October 2013. Poster presentation titled "Community based case-control rotavirus surveillance study amongchildren (< 5 yrs old) revealed coexistence of large number of Genotypes and increased prevalence of G9 strains in Kolkata.
  7. The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine, Sapporo, Japan, 16-18th October 2012. Poster presentation titled "Modulation of both cell survival and apoptotic pathways during virus infection by rotavirus encoded non-structural-4 (NSP4) and non structural-1 (NSP1) proteins".

Publications

2018

  1. Mukherjee A, Patra U, Bhowmick R, Chawla-Sarkar M. Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection. Cell Microbiol. 2018 Jun;20(6):e12831..
  2. Nayak MK,De P, Manna B, Dutta S, Bhadra UK, Chawla-Sarkar M. Species A rotaviruses isolated from hospitalized patients over 5 years of age in Kolkata, India, in 2012/13.Arch Virol. 2018 Mar;163(3):745-750.
  3. Banerjee A, Lo M, Indwar P, Deb AK, Das S, Manna B, Dutta S, Bhadra UK, Bhattacharya M, Okamoto K, Chawla-Sarkar M. Upsurge and spread of G3 rotaviruses in Eastern India (2014-2016): Full genome analyses reveals heterogeneity within Wa-like genomic constellation. Infect Genet Evol. 2018 May;63:158-174..

2017

  1. Doan YH, Suzuki Y, Fujii Y, Haga K, Fujimoto A, Takai-Todaka R, Someya Y, Nayak MK, Mukherjee A, Imamura D, Shinoda S, Chawla-Sarkar M, Katayama K. Complex reassortment events of unusual G9P[4] rotavirus strains in India between 2011 and 2013.Infect Genet Evol. 2017 Jul 25;54:417-428. . Pubmed
  2. Chattopadhyay S, Mukherjee A, Patra U, Bhowmick R, Basak T, Sengupta S, Chawla-Sarkar M. Tyrosine phosphorylation modulates mitochondrial chaperonin Hsp60 and delays rotavirus NSP4-mediated apoptotic signaling in host cells. Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12670.  Pubmed
  3. Banerjee A, De P, Manna B, Chawla-Sarkar M. Molecular characterization of enteric adenovirus genotypes 40 and 41 identified in children with acute gastroenteritis in Kolkata, India during 2013-2014. J Med Virol. 2017Sep 19; 89:606-614.   Pubmed
  4. Datta R, Bansal T, Rana S, Datta K, Datta Chaudhuri R, Chawla-Sarkar M, Sarkar S. Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.Mol Cell Biol. 2017 Mar 1;37.  Pubmed

2016

  1. Mukherjee A, Nayak MK, Dutta S, Panda S, Satpathi BR, Chawla-Sarkar M. Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India. PLoS One. 2016 Dec 20;11:e0168464.  Pubmed
  2. Mandal P, Mullick S, Nayak MK, Mukherjee A, Ganguly N, Niyogi P, Panda S, Chawla-Sarkar M. Complete genotyping of unusual species A rotavirus G12P[11] and G10P[14] isolates and evidence of frequent in vivo reassortment among the rotaviruses detected in children with diarrhea in Kolkata, India, during 2014. Arch Virol. 2016 Jul 22;161:2773-2785.  Pubmed
  3. Chanda S, Nandi S, Chawla-Sarkar M. 2016. Rotavirus induced miR-142-5p elicits proviral milieu by targeting Non-canonical TGFβ signalling and apoptosis in cells. Cell Microbiol. 18(5):733-47 2015. Pubmed

2015

  1. Deb Chanda S, Banerjee A, Chakrabarti S. and Chawla Sarkar M. Cordecypin an Adenosine Analogue executes anti-RV effects by stimulating Induction of Type I Interferon. J Virol Antiviral Res. 2015 May 25;4:2.
  2. Shaheen M, M. Borysanyiova, M. Chawla Sarkar, N. EL-Esnawy. 2015. In vitro effect of Dodonaea viscose extracts on the replication of coxackivirus B3 and rotavirus. J Microbiol Antimicrob Agents 1(2): 47-50.
  3. Datta R, T. Bansal, S. Rana, K. Datta, S. Chattopadhyay, M. Chawla-Sarkar, S. Sarkar. 2015.Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy. Cell Signal. 27(12):2410-24. Pubmed
  4. Sarkar T, S Das , A De , P Nandy, S Chattopadhyay , M. Chawla-Sarkar, A Nandy. 2015. H7N9 influenza outbreak in China 2013: In silico analyses of conserved segments of the hemagglutinin as a basis for the selection of peptide vaccine targets. Comput Biol Chem.59 Pt A:8-15. Pubmed
  5. Bhowmick R, A. Mukherjee, U. Patra , M.Chawla-Sarkar. 2015. Rotavirus disrupts cytoplasmic P bodies during infection. Virus Res. 210:344-54. Pubmed
  6. Chadha M.S, V.A Potdar, S. Saha, P..A. Koul, S. Broor, L. Dar, M. Chawla-Sarkar, D. Biswas, P. Gunasekaran, A. M. Abraham, S. Shrikhande, A.,Jain, B. Anukumar, R.B. Lal, A.C. Mishra. 2015.Dynamics of influenza seasonality at sub-regional levels in India and implications for vaccination timing.PLoS One. 10(5):e0124122. Pubmed
  7. Rana S., K. Datta, T.L. Reddy, E. Chatterjee, P. Sen, M. Pal-Bhadra, U. Bhadra, A. Pramanik, P. Pramanik, M. Chawla-Sarkar, S. Sarkar. 2015. A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. J Control Release. 200:167-78 Pubmed

2014

  1. Mullick S., A. Mukherjee , S. Ghosh , G.P. Pazhani, D. Sur , B. Manna , J. P. Nataro,M.M Levine , T. Ramamurthy , M.Chawla-Sarkar.2014 .Community based case-control study of rotavirus gastroenteritis among young children during 2008-2010 reveals vast genetic diversity and increased prevalence of G9 strains in Kolkata. PLoS One.9 (11):e112970. Pubmed
  2. Potdar V.A., M. R. Dakhave, P.B. Kulkarni, S.A. Tikhe, S. Broor, P. Gunashekaran, M. Chawla-Sarkar, A.Abraham, D. Biswas, K.N. Patil, A.A. Kadam, S.S. Kode, A.C. Mishra, M.S. Chadha. 2014. Antiviral drug profile of human influenza A B viruses circulating in India: 2004-2011. Indian J Med Res. 140(2):244-51. Pubmed
  3. Mullick S, P. Mandal, M.K. Nayak, S. Ghosh, P. De, K. Rajendran, M.K. Bhattacharya, U. Mitra, T. Ramamurthy, N. Kobayashi, M. Chawla-Sarkar. 2014. Hospital based surveillance and genetic characterization of rotavirus strains in children (5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011-2013. Vaccine 32 Suppl 1:A20-28. Pubmed
  4. Bhowmick R, G. Banik, S. Chanda, S. Chattopadhyay, M.Chawla-Sarkar. 2014. Rotavirus infection induces G1 to S phase transition in MA104 cells via Ca+ 2;/Calmodulin pathway. Virology 454-455:270-279. Pubmed
  5. Nandi S, S. Chanda, P. Bagchi, M. K. Nayak., R. Bhowmick, M.Chawla-Sarkar 2014. MAVS protein is attenuated by rotavirus nonstructural protein 1. PLoS One. 18;9(3):e92126. Pubmed
  6. Panda S, A.K. Deb, M. Chawla-Sarkar, T. Ramamurthy, S. Ganguly, P. Pradhan, A. Chakraborty, S. Desai, M.D. Gupte, R. Dhere 2014. Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India. Epidemiol Infect. 142:1848-1858. Pubmed
  7. Nayak MK, A.S Agrawal, S. Bose, S. Naskar, R. Bhowmick, S. Chakrabarti, S. Sarkar, M. Chawla-Sarkar. 2014. Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses. J Antimicrob Chemother. 69:1298-1310. Pubmed

2013

  1. Bagchi P, R Bhowmick, S Nandi, M Kant Nayak, M. Chawla-Sarkar.2013. Rotavirus NSP1 inhibits interferon induced non-canonical NF?B activation by interacting with TNF receptor associated factor 2. Virology 444: 41- 44 Pubmed
  2. Roy Mukherjee T, S Chanda, S Mullick, P De, M Dey-Sarkar, M.Chawla-Sarkar 2013. Spectrum of respiratory viruses circulating in eastern India: prospective surveillance among patients with influenza-like illness during 2010-2011. J Med Virol. 85: 1459-1465. Pubmed
  3. Mazumdar J, M Chawla-Sarkar, K Rajendran, A Ganguly, UK Sarkar, S,Ghosh, MD Sarkar, S. Maulik. Burden of respiratory tract infections among paediatric in and out-patient units during 2010-11. Eur Rev Med Pharmacol Sci. 17: 802-808. Pubmed
  4. Bhowmick R., U.C. Halder, S. Chattopadhyay, M.K. Nayak, M. Chawla-Sarkar. 2013. Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53. J Virol. 87(12):6840-50. Pubmed
  5. Roy Mukherjee T., A. Mukherjee, S. Mullick, M. Chawla-Sarkar. 2013. Full genome analysis and characterization of influenza C virus identified in Eastern India. Infect Genet Evol. 16:419-25. Pubmed
  6. Halder U.C, R. Bhowmick, T. Roy Mukherjee, M.K. Nayak, M. Chawla-Sarkar. 2013. Phosphorylation Drives an Apoptotic Protein to Activate Antiapoptotic Genes: Paradigm Of Influenza A Matrix 1 Protein Function. J. Biol. Chem. 288(20):14554-68. Pubmed
  7. Chattopadhyay S, T. Basak, M.K. Nayak, G. Bhardwaj, A. Mukherjee, R. Bhowmick, S. Sengupta, O. Chakrabarti, N.S. Chatterjee, M. Chawla-Sarkar. 2013. Identification of Cellular Calcium Binding Protein Calmodulin as a Regulator of Rotavirus A Infection during Comparative Proteomic Study. PLoS One. 8(2):e56655. Pubmed
  8. Mukherjee A, S. Mullick, A.K. Deb, S. Panda, M. Chawla-Sarkar. 2013. First report of human rotavirus G8P[4] gastroenteritis in India: evidence of ruminants-to-human zoonotic transmission. J. Med. Virol. 85(3):537-45. Pubmed
  9. Bagchi P, S. Nandi, M.K Nayak, M. Chawla-Sarkar. 2013. Molecular Mechanism behind Rotavirus NSP1-Mediated PI3 Kinase Activation: Interaction between NSP1 and the p85 Subunit of PI3 Kinase. J Virol. 87(4):2358-2362. Pubmed
  10. Ghosh S, N. Urushibara, M. Chawla-Sarkar, T. Krishnan, N. Kobayashi. 2013. Whole genomic analyses of asymptomatic human G1P[6], G2P[6] and G3P[6] rotavirus strains reveal intergenogroup reassortment events and genome segments of artiodactyl origin. Infect Genet. Evol.. 16C: 165-173. Pubmed
  11. Mullick S, A. Mukherjee, S. Ghosh, G.P. Pazhani, D. Sur, B. Manna, J.P. Nataro, M.M. Levine, T. Ramamurthy, M. Chawla-Sarkar. 2013. Genomic analysis of human rotavirus strains G6P[14] and G11P[25] isolated from Kolkata in 2009 reveals interspecies transmission and complex reassortment events. Infect. Genet. Evol. 14:15-21. Pubmed

2012

  1. Roy Mukherjee T, A.S. Agrawal, S. Chakrabarti, M. Chawla-Sarkar. 2012. Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: evidence of reassortment event between co-circulating A(H1N1)pdm09 and A/Brisbane/10/2007-like H3N2 strains. Virol J. 9: 233. Pubmed
  2. Mukherjee A, S. Mullick, N. Kobayashi, M. Chawla-Sarkar. 2012. The first identification of rare human group A rotavirus strain G3P[10] with severe infantile diarrhea in eastern India. Infect Genet Evol. 12: 1933-1937. Pubmed
  3. Bhowmick R, UC Halder , S Chattopadhyay , S Chanda , S Nandi , P Bagchi , MK Nayak , O Chakrabarti , N Kobayashi , M Chawla-Sarkar. 2012. Rotaviral Enterotoxin Nonstructural Protein 4 Targets Mitochondria for Activation of Apoptosis during Infection. J Biol Chem. 287: 35004-35020 Pubmed
  4. Bagchi P, S Nandi, S Chattopadhyay, R Bhowmick, UC Halder, MK Nayak, N Kobayashi, M Chawla-Sarkar.2012. Identification of common human host genes involved in pathogenesis of different rotavirus strains: an attempt to recognize probable antiviral targets.Virus Res. 169: 144-153. Pubmed
  5. Ghosh A, S. Chattopadhyay, M. Chawla-Sarkar, P. Nandy, A. Nandy. 2012. In silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine design. PLoS One.7: e40749 Pubmed
  6. Kahn G., S. Fitzwater, J. Tate, G. Kang, N. Ganguly, G. Nair, D. Steele, R. Arora,
    M. Chawla-Sarkar, U. Parashar, M. Santosham. 2012. Epidemiology and Prospects for
    Prevention of Rotavirus Disease in India. Indian Pediatr. 49: 467- 474. Pubmed
  7. Sarkar M., S. Chanda, S. Chakrabarti, J. Mazumdar, A. Ganguly, M.S.Chadha, A.C. Mishra, M. Chawla-Sarkar. 2012. Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating
    influenza A subtypes. Virol J. 9: 3. Pubmed
  8. Mukherjee A., M.K. Nayak, T. Roy, S. Ghosh, T.N. Naik, N. Kobayashi, M. Chawla-Sarkar 2012. Detection of human G10 rotavirus strains with similarity to bovine and bovine-like equine strains from untypable samples. Infect Genet Evol. 12: 467- 470. Pubmed
  9. Chadha M.S., S. Broor, P. Gunasekaran, V.A. Potdar, A. Krishnan, M Chawla-Sarkar,
    D. Biswas, A.M. Abraham, S.V Jalgaonkar, H.,Kaur, A. Klimov, R.B Lal, A Moen, L. Kant,
    A.C Mishra. 2012. Multisite virological influenza surveillance in India: 2004-2008.
    Influenza Other Respi Viruses. 6: 196-203. Pubmed

2011

  1. Halder U.C, P. Bagchi, S.Chattopadhyay, D. Dutta, M. Chawla-Sarkar. 2011. Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of
    viral control over the cellular survival pathway. Cell Death Dis. 2: e197. Pubmed
  2. Roy T., A.S Agrawal, A. Mukherjee, A.C Mishra, M.S. Chadha, H. Kaur, M.Chawla-Sarkar. 2011.Surveillance and molecular characterization of human influenza B viruses during 2006-2010 revealed co-circulation of Yamagata-like and Victoria-like strains in
    eastern India. Infect Genet Evol. 11:1595- 1601. Pubmed
  3. Koul P.A., M.A. Mir, N.K. Bali, M. Chawla-Sarkar, M. Sarkar, S. Kaushik, U.H. Khan, F Ahmad, R, Garten, R,B, Lal, S. Broor. 2011. Pandemic and seasonal influenza viruses among patients with acute respiratory illness in Kashmir (India). Influenza Other Respi Viruses. 5: e521-527. Pubmed
  4. Dutta D, Chattopadhyay S, Bagchi P, Halder UC, Nandi S, Mukherjee A, Kobayashi N, Taniguchi K, Chawla-Sarkar M. Active participation of cellular chaperone Hsp90 in regulating the function of rotavirus nonstructural protein 3 (NSP3). 2011. J Biol Chem, 286: 20065-2007. Pubmed
  5. Mukherjee A and Chawla-Sarkar M. Rotavirus Infection: A Perspective on Epidemiology, Genomic Diversity and Vaccine Strategies. 2011. Review, Indian J Virol, 22: 11-23.
  6. Ghosh A, Chawla-Sarkar M, Stuehr DJ. 2011 Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J. 25: 2049-2060. Pubmed
  7. Mukherjee A, Ghosh S, Bagchi P, Dutta D, Chattopadhyay S, Kobayashi N, Chawla-Sarkar M. Full genomic analyses of human G4P[4], G4P[6],G9P[19] and G10P[6] strains from North-eastern India: Evidence for interspecies transmission and complex reassortment events. 2011 Clin Microbiol Infect, 17: 1343-1346. Pubmed
  8. Sarkar M, A. S. Agrawal, R. Sharma Dey, S. Chattopadhyay, R. Mullick, P. De, S. Chakrabarti, M. Chawla-Sarkar. 2011. Molecular characterization and comparative analysis of pandemic H1N1/2009 strains with co-circulating seasonal H1N1/2009 strains from eastern India. Arch Virol. 156: 207-217. Pubmed
  9. Agrawal A. S, T. Roy, S. Ghosh, M. Chawla-Sarkar. 2011. Genetic variability of attachment (G) and Fusion (F) protein genes of human metapneumovirus strains circulating during 2006-2009 in Kolkata, Eastern India. Virol J. 8: 67. Pubmed
  10. Dey R. S, S. Ghosh, M. Chawla-Sarkar, S. Panchalingam, J. P. Nataro, D. Sur, B. Manna, T. Ramamurthy. 2011. Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India. J Clin Microbiol. 49: 500-505. Pubmed
  11. Yamamoto D, S. Ghosh, M. Kuzuya, Y.H. Wang, X. Zhou, M. Chawla-Sarkar, S.K. Paul, M. Ishino, N. Kobayashi. 2011. Whole-genome characterization of human group C rotaviruses: identification of two lineages in the VP3 gene. J Gen Virol. 92:361-369. Pubmed

2010

  1. Mukherjee A, Roy T, Agrawal AS, Sarkar M, Dey R, Chakrabarti S, Chawla-Sarkar M. 2010 Prevalence and epidemiology of pandemic H1N1strains in hospitals of Eastern India. J Pub Health Epidemiol, 2: 171-174.
  2. Agrawal, A. S., M. Sarkar, S. Ghosh, T. Roy, S. Chakrabarti, R. Lal, A. C. Mishra, M. S. Chadha, M. Chawla-Sarkar. 2010. Genetic characterization of circulating seasonal Influenza A viruses (2005-2009) revealed introduction of oseltamivir resistant H1N1 strains during 2009 in eastern India. Infect Genet Evol. 10: 1188-1198. Pubmed
  3. Chattopadhyay, S., P. Bagchi, D. Dutta, A. Mukherjee, N. Kobayashi, M. Chawla-Sarkar. 2010. Computational identification of post-translational modification sites and functional families reveal possible moonlighting role of rotaviral proteins. Bioinformation, 4(10): 448-451. Pubmed
  4. Bagchi P, D. Dutta, S. Chattopadhyay, A. Mukherjee, U.C. Halder, S. Sarkar, N. Kobayashi, S. Komoto, K. Taniguchi, M. Chawla-Sarkar 2010. Rotavirus Non-Structural Protein-1 suppresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection. J Virol. 84:6834-6845. Pubmed
  5. Nagashima S, N. Kobayashi , S.K. Paul , S. Ghosh, M. Chawla-Sarkar, M.A Hossain, Krishnan T 2010. Identification of P[8]b subtype in OP354 like human rotavirus strains by a modified RT-PCR. Jpn J Infect Dis. 63:208-211. Pubmed
  6. Ghosh S, N. Kobayashi, S. Nagashima, M. Chawla-Sarkar, T. Krishnan, B. Ganesh , T. N. Naik. 2010. Full genome analysis and possible origin of a porcine G12 rotavirus strain RU172. Virus Genes. 40: 382-388. Pubmed
  7. Yamamoto D, S. Ghosh, B. Ganesh, T. Krishnan, M Chawla-Sarkar, M. M Alam, T.S. Aung, N. Kobayashi 2010. Analysis on Genetic Diversity and Molecular Evolution of Human Group B Rotaviruses Based on Whole Genome Segments. J Gen Virol. 91:1772-1781 Pubmed
  8. Mukherjee A, S. Chattopadhyay, P. Bagchi, D. Dutta, N.B. Singh, R. Arora, U.D. Parashar, J.R. Gentsch, M. Chawla-Sarkar 2010. Surveillance and molecular characterization of rotavirus strains circulating in Manipur, north-eastern India: increasing prevalence of emerging G12 strains. Infect Genet Evol. 10:311-20. Pubmed
  9. Ghosh S., N. Kobayashi, S. Nagashima, M. Chawla-Sarkar, T. Krishnan, B. Ganesh, T.N. Naik 2010. Molecular characterization of the VP1, VP2, VP4, VP6, NSP1 and NSP2 genes of bovine grop B rotaviruses: identification of a novel VP4 genotype. Arch Virol. 155:159-167. Pubmed

2009

  1. Agrawal A.S., M. Sarkar, S. Chakrabarti, K. Rajendran, H. Kaur, A.C. Mishra, M.K.Chatterjee, T.N. Naik, M.S. Chadha, M Chawla-Sarkar 2009. Comparitive evaluation of real time PCR and conventional RT-PCR during a 2 year surveillance for influenza and respiratory syncytial virus among children with acute respiratory infections in Kolkata, India reveals distinct seasonality of infection. J Med Microbiol. 58:1616-1622. Pubmed
  2. Chattopadhyay D, M. Chawla- Sarkar, T. Chatterjee, R. Sharma Dey, P. Bag, S.Chakraborti and M. T. Hassan Khan 2009. Recent advancements for the evaluation of antiviral activities of natural products. N. Biotechnol. 25:347-368. Review. Pubmed
  3. Dutta D., P. Bagchi, A. Chatterjee, M.K. Nayak, A. Mukherjee, S. Chattopadhyay, S. Nagashima, N. Kobayashi, S. Komoto , K. Taniguchi, M.Chawla-Sarkar 2009. The molecular chaperone heat shock protein-90 positively regulates rotavirus infection. Virology 391:325-333. Pubmed
  4. Nagashima S, N. Kobayashi, S.K.Paul, M.M. Alam, M Chawla-Sarkar, T. Krishnan 2009. Characterization of full-length VP4 genes of OP354-like P[8] human rotavirus strains detected in Bangladesh representing a novel P[8] subtype. Arch Virol. 154: 1223-1231. Pubmed
  5. Agrawal, A. S., M. Sarkar, S. Ghosh, M. Chawla Sarkar, N. Chakraborty, M. Basak, T. N. Naik. 2009. Prevalence of respiratory syncytial virus group B genotype BA-IV strains among children with acute respiratory tract infection in Kolkata, Eastern India. J Clin Virol. 45: 358-61. Pubmed
  6. Mukherjee, A., D. Dutta, S. Ghosh, P. Bagchi, S. Chattopadhyay, S. Nagashima, N. Kobayashi, P. Dutta, T. Krishnan, T. N. Naik, M. Chawla Sarkar. 2009. Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine-to-human interspecies transmission. Arch Virol. 154: 733-46. Pubmed

2008

  1. Samajdar, S., S. Ghosh, D. Dutta, M. Chawla Sarkar, N .Kobayashi, T. N. Naik. 2008. Human group A rotavirus P[8] Hun9-like and rare OP354 like strains are circulating among diarhoeic children in Eastern India. Arch Virol. 153: 1933-1936. Pubmed
  2. Samajdar, S., S. Ghosh, M. Chawla Sarkar, U. Mitra, P. Dutta, N. Kobayashi, T. N. Naik. 2008. Increase in prevalence of human group A rotavirus G9 strains as an important VP7 genotype among children in Eastern India. J. Clin. Virol. 43: 334-339. Pubmed
  3. Nagashima, S., N. Kobayashi, M. Ishino, M. M. Alam, M. U. Ahmed, S. K. Paul, B. Ganesh, M. Chawla Sarkar, T. Krishnan, T. N. Naik, Y. H. Wang. 2008. Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus. J. Med. Virol. 80: 2023-2033. Pubmed
  4. Nayak, M. K., G. Balasubramanian, G. C. Sahoo, R. Bhattacharya, J. Vinje, N. Kobayashi, M. C. Sarkar, M. K. Bhattacharya, T. Krishnan. 2008. Detection of a novel intergenogroup recombinant Norovirus from Kolkata, India. Virology. 377: 117-23. Pubmed
  5. Alam, M. M., N. Kobayashi, M. Ishino, S. Nagashima, S. K. Paul, M. Chawla Sarkar, T. Krishnan, T. N. Naik. 2008. Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of Rotaviruses. Arch. Virol. 153: 555-559. Pubmed

2005

  1. Panda, K., M. Chawla Sarkar, C. Santos, T. Koeck, S. C. Erzurum, J. F. Parkinson and D. J. Stuehr. 2005. Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proc. Natl. Acad. Sci. U S A. 102: 10117-10122. Pubmed
  2. Vaziri, S. A., J. Hill, K. Chikamuri, M. Chawla Sarkar, and R. Ganapathi. 2005. Sensitization of DNA damage induced apoptosis by proteosome inhibitor PS-341 is p53 dependent involves target proteins 14-33 sigma surviving. Mol. Cancer Ther. 4: 1880-1890. Pubmed

2004

  1. Sarkar S, Chawla-Sarkar M, Young D, Nishiyama K, Rayborn ME, Hollyfield JG, Sen S. Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. 2004 J Biol Chem. 279: 52630-52642. Pubmed
  2. Chawla Sarkar, M., S. Bae, F. J. Reu, B. S. Jacobs, D. J. Lindner and E. C. Borden. 2004. Down-regulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death and Differentiation. 11: 915-923. Pubmed

2003

  1. Chawla Sarkar, M., J. A. Bauer, J. A. Lupica, B. Morrison, Z. Tang, R. K. Oates, A. Almasan, J. A. DiDonato, E. C. Borden and D. J. Lindner. 2003. Suppression of NF-?appa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. J. Biol. Chem. 278: 39461-39469. Pubmed
  2. Leaman, D. W., M. Chawla Sarkar, K. Vyas, A. Ozdemir and E. C. Borden. 2003. Greater potency of IFN-beta compared to IFN-alpha2 in inducing interferon stimulated genes (ISGs) in Melanoma. Identification of new ISGs by oligonucleotide microarray. J. IFN. and Cytokine Res. 23: 745-756. Pubmed
  3. Chawla Sarkar, M., D. Lindner, Y. Liu, B. Williams, G. Sen, R. Silverman and E. C. Borden. 2003. Apoptosis and Interferons: Role of interferon -stimulated genes as mediators of apoptosis. (Review) Apoptosis, 8: 237-249. Pubmed

2002

  1. Chawla Sarkar, M., D. W. Leaman, B. S. Jacobs and E. C. Borden. 2002. IFN pretreatment sensitizes melanoma cells to tumor necrosis factor related apoptosis inducing ligand (TRAIL/Apo2L) induced apoptosis. J. Immunol. 169: 847-855. Pubmed
  2. Chawla Sarkar. M., D. W. Leaman, B. S. Jacobs, R. J. Tuthill, M. Chatterjee Kishore, G. Stark and E. C. Borden. 2002. Resistance to Interferons does not correlate with expression and activation of signal transducer and activator of transcription (STAT1) in melanoma cell lines. J. IFN. and Cytokine Res. 22: 603-613.
  3. Basu, A., M. Chawla Sarkar and S. K. DasGupta. 2002. The repA and repB domains of Mycobacterial plasmid pAL5000 replication region act synergistically to activate the formation of an origin complex. J. Bacteriol. 184: 2204-2214. Pubmed
  4. Leaman, D. W., M. Chawla Sarkar, K. Vyas, K. Tamai and E. C. Borden. 2002. Identification of X-linked inhibitor of apoptosis associated factor-1 (XAF1) as an IFN-stimulated proapoptotic gene. J. Biol. Chem. 277: 28504-28511. Pubmed
  5. Morrison, B. H., J. A. Bauer, J. Hu, R. W. Grane, A. M. Ozdemir, M. Chawla Sarkar, B. Gong, A. Almasan, D. V. Kalvakolanu and D. J. Lindner. 2002. Inositol hexakisphohate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene. 21: 1882-1889. Pubmed

2001

  1. Chawla Sarkar, M., D. W. Leaman and E. C. Borden. 2001. Preferential induction of apoptosis by IFN compared to IFN: Correlation with TRAIL/Apo2L induction in melanoma cell lines. Clinical Cancer Research. 7: 1821-1831. Pubmed

1999

  1. Chawla, M., and S. K. DasGupta. 1999. Transposition induced structural instability of E.coli - mycobacteria shuttle vectors. Plasmid. 41: 135-140. Pubmed

Scientific Reviews

  1. Mukherjee A, Chatopadhyay S, Chawla-Sarkar M. Rotavirus Infection in India: A Major Cause of Childhood Gastroenteritis. Proc National Acad Sci, India Section B: Biol Sci. 2012 Mar 1;82(1):135-51.
  2. Kahn G, Fitzwater S, Tate J, Kang G, Ganguly N, Nair G, Steele D, Arora R, Chawla Sarkar M, Parashar U, Santosham M. Epidemiology and prospects for prevention of rotavirus disease in India. Indian Pediatr. 2012 Jun 1;49(6):467-74.  Pubmed
  3. Mukherjee A, Chawla-Sarkar M. Rotavirus infection: a perspective on epidemiology, genomic diversity and vaccine strategies. Indian J Virol. 2011 Jun 1;22(1):11-23 Pubmed
  4. Chattopadhyay D, Chawla-Sarkar M, Chatterjee T, Dey RS, Bag P, Chakraborti S, Khan MT. Recent advancements for the evaluation of anti-viral activities of natural products. New Biotechnol 2009 Jun 30;25(5):347-68.  Pubmed
  5. Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH, Borden EC. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003 Jun 1;8(3):237-49.   Pubmed

Book Chapters

  1. Kobayashi N, Ishino M, Wang YH, Chawla-Sarkar M, Krishnan T, Naik TN. Diversity of G-type and P-type of human and animal rotaviruses and its genetic background. Communicating Curr Res Educ Top Trends ApplMicrobiol. 2007:847-58..
  2. Chawla-Sarkar M., P. Masci and E C Borden.Interferons for cancer therapy: Key contributions of recombinant biotechnology,InEd Rodney, J. Y. Ho and M. Gibaldi (ed.), Biotechnology & Biopharmaceuticals: Transforming Proteins and Genes into Drugs. J Wiley & Sons Inc., New Jersey, USA. 2003: p. 161-179. 

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