National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. Mamta Chawla Sarkar

Dr. Mamta Chawla Sarkar

Dr. Mamta Chawla-Sarkar joined as Scientist C in Division. of Virology, NICED, Kolkata in January 2006. Dr Chawla Sarkar gained her Master's in Zoology in 1992 from Calcutta University and acquired the degree of Ph.D from Bose Institute-Jadavpur University, Kolkata in 1999. She did her Post-doctoral research work as Research Associate for six years in the Center for drug discovery & development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland. The research project was on analysis of the genes involved in antitumor effects of Interferons and the mechanisms underlying IFN resistance in tumors of different histopathologies. In addition she was also involved in project on role of heme insertion in dimerization and activity of inducible nitric oxide synthetase and study the effect of heme binding inhibitors in modulating NOS activity in various pathological disorders. After joining Division of Virology at NICED, Dr Chawla-Sarkar has been involved in studying two viruses namely Influenza virus and Rotavirus. Her research focus involves strain surveillance, Host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets. As a scientist -in-charge for Influenza surveillance in NICED, Dr Chawla-Sarkar was responsible for providing laboratory support for states in Eastern India during A/H1N1 pandemic in 2009. In 2010, she was promoted to Scientist D (Assistant Director). In 2013, she was elected Fellow of the National academy of science in India (NASI). She was honored with "National Women Bioscientist Award" by Department of Biotechnology in 2013. She is currently working on four projects:

  1. Multisite monitoring of Influenza Virus strains in India.
  2. Analysis of the Rotavirus-host cell interaction: Study of role of Rotavirus encoded proteins and host cellular proteins during virus infection.
  3. Analysis of the Rotavirus-host cell interaction: Study of role of Rotavirus encoded proteins and host cellular proteins during virus infection.
  4. National Rotavirus Surveillance Network.

Dr. Chawla-Sarkar has trained number of students and project staff in various aspects of virus research. Six students have completed their Ph.D. program under her guidance and are now doing post doctoral training in USA and Europe. Currently six students are enrolled for Ph.D. under her guidance. She is the author of more than 65 research papers in the peer-reviewed international journals and two Book chapters in the area of Molecular biotechnology, Immunology, Biological Chemistry and Virology.

General Information
Name Dr. Mamta Chawla Sarkar
Educational Qualification M.Sc., Ph.D., FNASc
Designation Scientist E
Division Virology
Specialization Virology, Molecular Biology
Date of joining ICMR 10th January 2006
Email : sarkarmc@icmr.org.in , chawlam70@gmail.com

Profile

Professional Experience

Dr. Chawla-Sarkar did her Post-doctoral research work as Research Associate from Feb 1999- Nov 2003 in Center for drug discovery & development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland. The research project was on analysis of the genes involved in antitumor effects of IFNs and the mechanisms underlying IFN resistance in tumors of different histopathologies. During her tenure, she was awarded the research award (2002-2004) for a study on "Evaluation of Bcl2-Antisense oligonucleotide (Genasense) and IFN as co-therapeutic agent in-vitro in solid tumor cell lines". On completion of the project, she shifted her research focus in Immunology from 2004-2005 to understand the role of heme insertion in dimerization and activity of inducible nitric oxide synthetase and study the effect of heme binding inhibitors in modulating NOS activity in various pathological disorders.

In January 2006, Dr Chawla-Sarkar joined in Division of Virology at NICED as Scientist C. Her research focus involves strain surveillance, Host-virus interaction and identifying cellular proteins involved in viral pathogenesis for developing potential antiviral targets with focus on Influenza and Rotavirus. As a scientist -in-charge for Influenza surveillance in NICED, Dr Chawla-Sarkar was responsible for providing laboratory support for states in Eastern India during A/H1N1 pandemic in 2009. In 2010, she was promoted to Scientist D (Assistant Director). In 2013, she was elected Fellow of the National academy of science in India (NASI). She was honored with "National Women Bioscientist Award" by Department of Biotechnology in 2013.

Research Interests

Innate immune response and intrinsic cellular defenses are effective antiviral strategies of the host. Most of these pathways are highly conserved and arose early in evolution. Interferons, the first line of defense mechanism are activated by the host cells in response to viral RNA or the dsRNA. IFNs induce synthesis of more than 300 cellular proteins such as RNase L, PKR, Interferon regulatory factors (IRFs) with broad spectrum anti-viral activities, depending on cell type, virus, and other cytokines sensed by the cells. Many of these IFN-stimulated proteins have been studied in context of their signaling pathways in various viral infections, but still many remain to be explored in details. Not surprisingly, the viruses have evolved mechanisms for evading these responses by encoding wide range of inhibitory proteins. However, very little has been studied regarding role of rotavirus encoded proteins in modulation of cellular responses during infection. Thus to overcome the viral disease burden, there is a need to understand the role of host cell during viral pathogenesis. Identification of cellular proteins with anti viral function or the viral-encoded inhibitory proteins which help viruses to evade immune responsewill help in designing antiviral therapeutics.

Projects

Intramural

  • Exploring the role of the rotavirus encoded non-structural protein(s) in evasion of cellular immune responses ( 2007-2013)
  • Analysis of the Rotavirus-host cell interaction: Study of role of Rotavirus encoded proteins and host cellular proteins during virus infection( 2013-2017)

Extramural

  • Multisite Monitoring of Influenza virus strains Phase I and II ( 2006- contd): Funded by ICMR and DHHS, USA
  • Analysis of the signaling mechanisms and immune responses during Rotavirus- host cell interactions: Study of host cellular proteins required for viral replication and pathogenesis. (2007-2010): Funded by Okayama University, Japan
  • Analysis of rotaviruses and their interactions with the host: A Viral Proteomics Approach ( 2010-2015): Funded by Okayama University, Japan
  • "National Rotavirus Surveillance Network" ( 2013-2016): Funded by ICMR

Pre-doctoral and Post-doctoral Students

  • Dr Mukti Kant Nayak (Project Scientist)
  • Rahul Bhowmick (SRF)
  • Satabdi Nandi (SRF)
  • Shampa Chanda (SRF)
  • Paulami Mandal (JRF)
  • Satarupa Mullick ( SRF)
  • Upayan Patra (JRF)
  • Arpita Mukherjee ( JRF)

Memberships

  • The Indian Science Congress Association: Life Member
  • Society of Biological Chemists, India : Life Member
  • Indian Virology Society, India : Life Member

Publications

2016

  1. Chanda S, Nandi S, Chawla-Sarkar M. 2016. Rotavirus induced miR-142-5p elicits proviral milieu by targeting Non-canonical TGFβ signalling and apoptosis in cells. Cell Microbiol. 18(5):733-47 2015. Pubmed
  2. Mandal P, Mullick S, Nayak MK, Mukherjee A, Ganguly N, Niyogi P, Panda S, Chawla-Sarkar M. 2016. Complete genotyping of unusual species A rotavirus G12P[11] and G10P[14] isolates and evidence of frequent in vivo reassortment among the rotaviruses detected in children with diarrhea in Kolkata, India, during 2014. Arch Virol. 161(10):2773-85. Pubmed

2015

  1. Deb Chanda S, A. Banerjee, S. Chakrabarti and M. Chawla Sarkar. 2015. Cordecypin an Adenosine Analogue executes anti-RV effects by stimulating Induction of Type I Interferon. J Virol Antivir Res. 4:2
  2. Shaheen M, M. Borysanyiova, M. Chawla Sarkar, N. EL-Esnawy. 2015. In vitro effect of Dodonaea viscose extracts on the replication of coxackivirus B3 and rotavirus. J Microbiol Antimicrob Agents 1(2): 47-50.
  3. Datta R, T. Bansal, S. Rana, K. Datta, S. Chattopadhyay, M. Chawla-Sarkar, S. Sarkar. 2015.Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy. Cell Signal. 27(12):2410-24. Pubmed
  4. Sarkar T, S Das , A De , P Nandy, S Chattopadhyay , M. Chawla-Sarkar, A Nandy. 2015. H7N9 influenza outbreak in China 2013: In silico analyses of conserved segments of the hemagglutinin as a basis for the selection of peptide vaccine targets. Comput Biol Chem.59 Pt A:8-15. Pubmed
  5. Bhowmick R, A. Mukherjee, U. Patra , M.Chawla-Sarkar. 2015. Rotavirus disrupts cytoplasmic P bodies during infection. Virus Res. 210:344-54. Pubmed
  6. Chadha M.S, V.A Potdar, S. Saha, P..A. Koul, S. Broor, L. Dar, M. Chawla-Sarkar, D. Biswas, P. Gunasekaran, A. M. Abraham, S. Shrikhande, A.,Jain, B. Anukumar, R.B. Lal, A.C. Mishra. 2015.Dynamics of influenza seasonality at sub-regional levels in India and implications for vaccination timing.PLoS One. 10(5):e0124122. Pubmed
  7. Rana S., K. Datta, T.L. Reddy, E. Chatterjee, P. Sen, M. Pal-Bhadra, U. Bhadra, A. Pramanik, P. Pramanik, M. Chawla-Sarkar, S. Sarkar. 2015. A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. J Control Release. 200:167-78 Pubmed

2014

  1. Mullick S., A. Mukherjee , S. Ghosh , G.P. Pazhani, D. Sur , B. Manna , J. P. Nataro,M.M Levine , T. Ramamurthy , M.Chawla-Sarkar.2014 .Community based case-control study of rotavirus gastroenteritis among young children during 2008-2010 reveals vast genetic diversity and increased prevalence of G9 strains in Kolkata. PLoS One.9 (11):e112970. Pubmed
  2. Potdar V.A., M. R. Dakhave, P.B. Kulkarni, S.A. Tikhe, S. Broor, P. Gunashekaran, M. Chawla-Sarkar, A.Abraham, D. Biswas, K.N. Patil, A.A. Kadam, S.S. Kode, A.C. Mishra, M.S. Chadha. 2014. Antiviral drug profile of human influenza A B viruses circulating in India: 2004-2011. Indian J Med Res. 140(2):244-51. Pubmed
  3. Mullick S, P. Mandal, M.K. Nayak, S. Ghosh, P. De, K. Rajendran, M.K. Bhattacharya, U. Mitra, T. Ramamurthy, N. Kobayashi, M. Chawla-Sarkar. 2014. Hospital based surveillance and genetic characterization of rotavirus strains in children (5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011-2013. Vaccine 32 Suppl 1:A20-28. Pubmed
  4. Bhowmick R, G. Banik, S. Chanda, S. Chattopadhyay, M.Chawla-Sarkar. 2014. Rotavirus infection induces G1 to S phase transition in MA104 cells via Ca+ 2;/Calmodulin pathway. Virology 454-455:270-279. Pubmed
  5. Nandi S, S. Chanda, P. Bagchi, M. K. Nayak., R. Bhowmick, M.Chawla-Sarkar 2014. MAVS protein is attenuated by rotavirus nonstructural protein 1. PLoS One. 18;9(3):e92126. Pubmed
  6. Panda S, A.K. Deb, M. Chawla-Sarkar, T. Ramamurthy, S. Ganguly, P. Pradhan, A. Chakraborty, S. Desai, M.D. Gupte, R. Dhere 2014. Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India. Epidemiol Infect. 142:1848-1858. Pubmed
  7. Nayak MK, A.S Agrawal, S. Bose, S. Naskar, R. Bhowmick, S. Chakrabarti, S. Sarkar, M. Chawla-Sarkar. 2014. Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses. J Antimicrob Chemother. 69:1298-1310. Pubmed

2013

  1. Bagchi P, R Bhowmick, S Nandi, M Kant Nayak, M. Chawla-Sarkar.2013. Rotavirus NSP1 inhibits interferon induced non-canonical NF?B activation by interacting with TNF receptor associated factor 2. Virology 444: 41- 44 Pubmed
  2. Roy Mukherjee T, S Chanda, S Mullick, P De, M Dey-Sarkar, M.Chawla-Sarkar 2013. Spectrum of respiratory viruses circulating in eastern India: prospective surveillance among patients with influenza-like illness during 2010-2011. J Med Virol. 85: 1459-1465. Pubmed
  3. Mazumdar J, M Chawla-Sarkar, K Rajendran, A Ganguly, UK Sarkar, S,Ghosh, MD Sarkar, S. Maulik. Burden of respiratory tract infections among paediatric in and out-patient units during 2010-11. Eur Rev Med Pharmacol Sci. 17: 802-808. Pubmed
  4. Bhowmick R., U.C. Halder, S. Chattopadhyay, M.K. Nayak, M. Chawla-Sarkar. 2013. Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53. J Virol. 87(12):6840-50. Pubmed
  5. Roy Mukherjee T., A. Mukherjee, S. Mullick, M. Chawla-Sarkar. 2013. Full genome analysis and characterization of influenza C virus identified in Eastern India. Infect Genet Evol. 16:419-25. Pubmed
  6. Halder U.C, R. Bhowmick, T. Roy Mukherjee, M.K. Nayak, M. Chawla-Sarkar. 2013. Phosphorylation Drives an Apoptotic Protein to Activate Antiapoptotic Genes: Paradigm Of Influenza A Matrix 1 Protein Function. J. Biol. Chem. 288(20):14554-68. Pubmed
  7. Chattopadhyay S, T. Basak, M.K. Nayak, G. Bhardwaj, A. Mukherjee, R. Bhowmick, S. Sengupta, O. Chakrabarti, N.S. Chatterjee, M. Chawla-Sarkar. 2013. Identification of Cellular Calcium Binding Protein Calmodulin as a Regulator of Rotavirus A Infection during Comparative Proteomic Study. PLoS One. 8(2):e56655. Pubmed
  8. Mukherjee A, S. Mullick, A.K. Deb, S. Panda, M. Chawla-Sarkar. 2013. First report of human rotavirus G8P[4] gastroenteritis in India: evidence of ruminants-to-human zoonotic transmission. J. Med. Virol. 85(3):537-45. Pubmed
  9. Bagchi P, S. Nandi, M.K Nayak, M. Chawla-Sarkar. 2013. Molecular Mechanism behind Rotavirus NSP1-Mediated PI3 Kinase Activation: Interaction between NSP1 and the p85 Subunit of PI3 Kinase. J Virol. 87(4):2358-2362. Pubmed
  10. Ghosh S, N. Urushibara, M. Chawla-Sarkar, T. Krishnan, N. Kobayashi. 2013. Whole genomic analyses of asymptomatic human G1P[6], G2P[6] and G3P[6] rotavirus strains reveal intergenogroup reassortment events and genome segments of artiodactyl origin. Infect Genet. Evol.. 16C: 165-173. Pubmed
  11. Mullick S, A. Mukherjee, S. Ghosh, G.P. Pazhani, D. Sur, B. Manna, J.P. Nataro, M.M. Levine, T. Ramamurthy, M. Chawla-Sarkar. 2013. Genomic analysis of human rotavirus strains G6P[14] and G11P[25] isolated from Kolkata in 2009 reveals interspecies transmission and complex reassortment events. Infect. Genet. Evol. 14:15-21. Pubmed

2012

  1. Roy Mukherjee T, A.S. Agrawal, S. Chakrabarti, M. Chawla-Sarkar. 2012. Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: evidence of reassortment event between co-circulating A(H1N1)pdm09 and A/Brisbane/10/2007-like H3N2 strains. Virol J. 9: 233. Pubmed
  2. Mukherjee A, S. Mullick, N. Kobayashi, M. Chawla-Sarkar. 2012. The first identification of rare human group A rotavirus strain G3P[10] with severe infantile diarrhea in eastern India. Infect Genet Evol. 12: 1933-1937. Pubmed
  3. Bhowmick R, UC Halder , S Chattopadhyay , S Chanda , S Nandi , P Bagchi , MK Nayak , O Chakrabarti , N Kobayashi , M Chawla-Sarkar. 2012. Rotaviral Enterotoxin Nonstructural Protein 4 Targets Mitochondria for Activation of Apoptosis during Infection. J Biol Chem. 287: 35004-35020 Pubmed
  4. Bagchi P, S Nandi, S Chattopadhyay, R Bhowmick, UC Halder, MK Nayak, N Kobayashi, M Chawla-Sarkar.2012. Identification of common human host genes involved in pathogenesis of different rotavirus strains: an attempt to recognize probable antiviral targets.Virus Res. 169: 144-153. Pubmed
  5. Ghosh A, S. Chattopadhyay, M. Chawla-Sarkar, P. Nandy, A. Nandy. 2012. In silico study of rotavirus VP7 surface accessible conserved regions for antiviral drug/vaccine design. PLoS One.7: e40749 Pubmed
  6. Kahn G., S. Fitzwater, J. Tate, G. Kang, N. Ganguly, G. Nair, D. Steele, R. Arora,
    M. Chawla-Sarkar, U. Parashar, M. Santosham. 2012. Epidemiology and Prospects for
    Prevention of Rotavirus Disease in India. Indian Pediatr. 49: 467- 474. Pubmed
  7. Sarkar M., S. Chanda, S. Chakrabarti, J. Mazumdar, A. Ganguly, M.S.Chadha, A.C. Mishra, M. Chawla-Sarkar. 2012. Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating
    influenza A subtypes. Virol J. 9: 3. Pubmed
  8. Mukherjee A., M.K. Nayak, T. Roy, S. Ghosh, T.N. Naik, N. Kobayashi, M. Chawla-Sarkar 2012. Detection of human G10 rotavirus strains with similarity to bovine and bovine-like equine strains from untypable samples. Infect Genet Evol. 12: 467- 470. Pubmed
  9. Chadha M.S., S. Broor, P. Gunasekaran, V.A. Potdar, A. Krishnan, M Chawla-Sarkar,
    D. Biswas, A.M. Abraham, S.V Jalgaonkar, H.,Kaur, A. Klimov, R.B Lal, A Moen, L. Kant,
    A.C Mishra. 2012. Multisite virological influenza surveillance in India: 2004-2008.
    Influenza Other Respi Viruses. 6: 196-203. Pubmed

2011

  1. Halder U.C, P. Bagchi, S.Chattopadhyay, D. Dutta, M. Chawla-Sarkar. 2011. Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of
    viral control over the cellular survival pathway. Cell Death Dis. 2: e197. Pubmed
  2. Roy T., A.S Agrawal, A. Mukherjee, A.C Mishra, M.S. Chadha, H. Kaur, M.Chawla-Sarkar. 2011.Surveillance and molecular characterization of human influenza B viruses during 2006-2010 revealed co-circulation of Yamagata-like and Victoria-like strains in
    eastern India. Infect Genet Evol. 11:1595- 1601. Pubmed
  3. Koul P.A., M.A. Mir, N.K. Bali, M. Chawla-Sarkar, M. Sarkar, S. Kaushik, U.H. Khan, F Ahmad, R, Garten, R,B, Lal, S. Broor. 2011. Pandemic and seasonal influenza viruses among patients with acute respiratory illness in Kashmir (India). Influenza Other Respi Viruses. 5: e521-527. Pubmed
  4. Dutta D, Chattopadhyay S, Bagchi P, Halder UC, Nandi S, Mukherjee A, Kobayashi N, Taniguchi K, Chawla-Sarkar M. Active participation of cellular chaperone Hsp90 in regulating the function of rotavirus nonstructural protein 3 (NSP3). 2011. J Biol Chem, 286: 20065-2007. Pubmed
  5. Mukherjee A and Chawla-Sarkar M. Rotavirus Infection: A Perspective on Epidemiology, Genomic Diversity and Vaccine Strategies. 2011. Review, Indian J Virol, 22: 11-23.
  6. Ghosh A, Chawla-Sarkar M, Stuehr DJ. 2011 Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J. 25: 2049-2060. Pubmed
  7. Mukherjee A, Ghosh S, Bagchi P, Dutta D, Chattopadhyay S, Kobayashi N, Chawla-Sarkar M. Full genomic analyses of human G4P[4], G4P[6],G9P[19] and G10P[6] strains from North-eastern India: Evidence for interspecies transmission and complex reassortment events. 2011 Clin Microbiol Infect, 17: 1343-1346. Pubmed
  8. Sarkar M, A. S. Agrawal, R. Sharma Dey, S. Chattopadhyay, R. Mullick, P. De, S. Chakrabarti, M. Chawla-Sarkar. 2011. Molecular characterization and comparative analysis of pandemic H1N1/2009 strains with co-circulating seasonal H1N1/2009 strains from eastern India. Arch Virol. 156: 207-217. Pubmed
  9. Agrawal A. S, T. Roy, S. Ghosh, M. Chawla-Sarkar. 2011. Genetic variability of attachment (G) and Fusion (F) protein genes of human metapneumovirus strains circulating during 2006-2009 in Kolkata, Eastern India. Virol J. 8: 67. Pubmed
  10. Dey R. S, S. Ghosh, M. Chawla-Sarkar, S. Panchalingam, J. P. Nataro, D. Sur, B. Manna, T. Ramamurthy. 2011. Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India. J Clin Microbiol. 49: 500-505. Pubmed
  11. Yamamoto D, S. Ghosh, M. Kuzuya, Y.H. Wang, X. Zhou, M. Chawla-Sarkar, S.K. Paul, M. Ishino, N. Kobayashi. 2011. Whole-genome characterization of human group C rotaviruses: identification of two lineages in the VP3 gene. J Gen Virol. 92:361-369. Pubmed

2010

  1. Mukherjee A, Roy T, Agrawal AS, Sarkar M, Dey R, Chakrabarti S, Chawla-Sarkar M. 2010 Prevalence and epidemiology of pandemic H1N1strains in hospitals of Eastern India. J Pub Health Epidemiol, 2: 171-174.
  2. Agrawal, A. S., M. Sarkar, S. Ghosh, T. Roy, S. Chakrabarti, R. Lal, A. C. Mishra, M. S. Chadha, M. Chawla-Sarkar. 2010. Genetic characterization of circulating seasonal Influenza A viruses (2005-2009) revealed introduction of oseltamivir resistant H1N1 strains during 2009 in eastern India. Infect Genet Evol. 10: 1188-1198. Pubmed
  3. Chattopadhyay, S., P. Bagchi, D. Dutta, A. Mukherjee, N. Kobayashi, M. Chawla-Sarkar. 2010. Computational identification of post-translational modification sites and functional families reveal possible moonlighting role of rotaviral proteins. Bioinformation, 4(10): 448-451. Pubmed
  4. Bagchi P, D. Dutta, S. Chattopadhyay, A. Mukherjee, U.C. Halder, S. Sarkar, N. Kobayashi, S. Komoto, K. Taniguchi, M. Chawla-Sarkar 2010. Rotavirus Non-Structural Protein-1 suppresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection. J Virol. 84:6834-6845. Pubmed
  5. Nagashima S, N. Kobayashi , S.K. Paul , S. Ghosh, M. Chawla-Sarkar, M.A Hossain, Krishnan T 2010. Identification of P[8]b subtype in OP354 like human rotavirus strains by a modified RT-PCR. Jpn J Infect Dis. 63:208-211. Pubmed
  6. Ghosh S, N. Kobayashi, S. Nagashima, M. Chawla-Sarkar, T. Krishnan, B. Ganesh , T. N. Naik. 2010. Full genome analysis and possible origin of a porcine G12 rotavirus strain RU172. Virus Genes. 40: 382-388. Pubmed
  7. Yamamoto D, S. Ghosh, B. Ganesh, T. Krishnan, M Chawla-Sarkar, M. M Alam, T.S. Aung, N. Kobayashi 2010. Analysis on Genetic Diversity and Molecular Evolution of Human Group B Rotaviruses Based on Whole Genome Segments. J Gen Virol. 91:1772-1781 Pubmed
  8. Mukherjee A, S. Chattopadhyay, P. Bagchi, D. Dutta, N.B. Singh, R. Arora, U.D. Parashar, J.R. Gentsch, M. Chawla-Sarkar 2010. Surveillance and molecular characterization of rotavirus strains circulating in Manipur, north-eastern India: increasing prevalence of emerging G12 strains. Infect Genet Evol. 10:311-20. Pubmed
  9. Ghosh S., N. Kobayashi, S. Nagashima, M. Chawla-Sarkar, T. Krishnan, B. Ganesh, T.N. Naik 2010. Molecular characterization of the VP1, VP2, VP4, VP6, NSP1 and NSP2 genes of bovine grop B rotaviruses: identification of a novel VP4 genotype. Arch Virol. 155:159-167. Pubmed

2009

  1. Agrawal A.S., M. Sarkar, S. Chakrabarti, K. Rajendran, H. Kaur, A.C. Mishra, M.K.Chatterjee, T.N. Naik, M.S. Chadha, M Chawla-Sarkar 2009. Comparitive evaluation of real time PCR and conventional RT-PCR during a 2 year surveillance for influenza and respiratory syncytial virus among children with acute respiratory infections in Kolkata, India reveals distinct seasonality of infection. J Med Microbiol. 58:1616-1622. Pubmed
  2. Chattopadhyay D, M. Chawla- Sarkar, T. Chatterjee, R. Sharma Dey, P. Bag, S.Chakraborti and M. T. Hassan Khan 2009. Recent advancements for the evaluation of antiviral activities of natural products. N. Biotechnol. 25:347-368. Review. Pubmed
  3. Dutta D., P. Bagchi, A. Chatterjee, M.K. Nayak, A. Mukherjee, S. Chattopadhyay, S. Nagashima, N. Kobayashi, S. Komoto , K. Taniguchi, M.Chawla-Sarkar 2009. The molecular chaperone heat shock protein-90 positively regulates rotavirus infection. Virology 391:325-333. Pubmed
  4. Nagashima S, N. Kobayashi, S.K.Paul, M.M. Alam, M Chawla-Sarkar, T. Krishnan 2009. Characterization of full-length VP4 genes of OP354-like P[8] human rotavirus strains detected in Bangladesh representing a novel P[8] subtype. Arch Virol. 154: 1223-1231. Pubmed
  5. Agrawal, A. S., M. Sarkar, S. Ghosh, M. Chawla Sarkar, N. Chakraborty, M. Basak, T. N. Naik. 2009. Prevalence of respiratory syncytial virus group B genotype BA-IV strains among children with acute respiratory tract infection in Kolkata, Eastern India. J Clin Virol. 45: 358-61. Pubmed
  6. Mukherjee, A., D. Dutta, S. Ghosh, P. Bagchi, S. Chattopadhyay, S. Nagashima, N. Kobayashi, P. Dutta, T. Krishnan, T. N. Naik, M. Chawla Sarkar. 2009. Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine-to-human interspecies transmission. Arch Virol. 154: 733-46. Pubmed

2008

  1. Samajdar, S., S. Ghosh, D. Dutta, M. Chawla Sarkar, N .Kobayashi, T. N. Naik. 2008. Human group A rotavirus P[8] Hun9-like and rare OP354 like strains are circulating among diarhoeic children in Eastern India. Arch Virol. 153: 1933-1936. Pubmed
  2. Samajdar, S., S. Ghosh, M. Chawla Sarkar, U. Mitra, P. Dutta, N. Kobayashi, T. N. Naik. 2008. Increase in prevalence of human group A rotavirus G9 strains as an important VP7 genotype among children in Eastern India. J. Clin. Virol. 43: 334-339. Pubmed
  3. Nagashima, S., N. Kobayashi, M. Ishino, M. M. Alam, M. U. Ahmed, S. K. Paul, B. Ganesh, M. Chawla Sarkar, T. Krishnan, T. N. Naik, Y. H. Wang. 2008. Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus. J. Med. Virol. 80: 2023-2033. Pubmed
  4. Nayak, M. K., G. Balasubramanian, G. C. Sahoo, R. Bhattacharya, J. Vinje, N. Kobayashi, M. C. Sarkar, M. K. Bhattacharya, T. Krishnan. 2008. Detection of a novel intergenogroup recombinant Norovirus from Kolkata, India. Virology. 377: 117-23. Pubmed
  5. Alam, M. M., N. Kobayashi, M. Ishino, S. Nagashima, S. K. Paul, M. Chawla Sarkar, T. Krishnan, T. N. Naik. 2008. Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of Rotaviruses. Arch. Virol. 153: 555-559. Pubmed

2005

  1. Panda, K., M. Chawla Sarkar, C. Santos, T. Koeck, S. C. Erzurum, J. F. Parkinson and D. J. Stuehr. 2005. Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proc. Natl. Acad. Sci. U S A. 102: 10117-10122. Pubmed
  2. Vaziri, S. A., J. Hill, K. Chikamuri, M. Chawla Sarkar, and R. Ganapathi. 2005. Sensitization of DNA damage induced apoptosis by proteosome inhibitor PS-341 is p53 dependent involves target proteins 14-33 sigma surviving. Mol. Cancer Ther. 4: 1880-1890. Pubmed

2004

  1. Sarkar S, Chawla-Sarkar M, Young D, Nishiyama K, Rayborn ME, Hollyfield JG, Sen S. Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. 2004 J Biol Chem. 279: 52630-52642. Pubmed
  2. Chawla Sarkar, M., S. Bae, F. J. Reu, B. S. Jacobs, D. J. Lindner and E. C. Borden. 2004. Down-regulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death and Differentiation. 11: 915-923. Pubmed

2003

  1. Chawla Sarkar, M., J. A. Bauer, J. A. Lupica, B. Morrison, Z. Tang, R. K. Oates, A. Almasan, J. A. DiDonato, E. C. Borden and D. J. Lindner. 2003. Suppression of NF-?appa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. J. Biol. Chem. 278: 39461-39469. Pubmed
  2. Leaman, D. W., M. Chawla Sarkar, K. Vyas, A. Ozdemir and E. C. Borden. 2003. Greater potency of IFN-beta compared to IFN-alpha2 in inducing interferon stimulated genes (ISGs) in Melanoma. Identification of new ISGs by oligonucleotide microarray. J. IFN. and Cytokine Res. 23: 745-756. Pubmed
  3. Chawla Sarkar, M., D. Lindner, Y. Liu, B. Williams, G. Sen, R. Silverman and E. C. Borden. 2003. Apoptosis and Interferons: Role of interferon -stimulated genes as mediators of apoptosis. (Review) Apoptosis, 8: 237-249. Pubmed

2002

  1. Chawla Sarkar, M., D. W. Leaman, B. S. Jacobs and E. C. Borden. 2002. IFN pretreatment sensitizes melanoma cells to tumor necrosis factor related apoptosis inducing ligand (TRAIL/Apo2L) induced apoptosis. J. Immunol. 169: 847-855. Pubmed
  2. Chawla Sarkar. M., D. W. Leaman, B. S. Jacobs, R. J. Tuthill, M. Chatterjee Kishore, G. Stark and E. C. Borden. 2002. Resistance to Interferons does not correlate with expression and activation of signal transducer and activator of transcription (STAT1) in melanoma cell lines. J. IFN. and Cytokine Res. 22: 603-613.
  3. Basu, A., M. Chawla Sarkar and S. K. DasGupta. 2002. The repA and repB domains of Mycobacterial plasmid pAL5000 replication region act synergistically to activate the formation of an origin complex. J. Bacteriol. 184: 2204-2214. Pubmed
  4. Leaman, D. W., M. Chawla Sarkar, K. Vyas, K. Tamai and E. C. Borden. 2002. Identification of X-linked inhibitor of apoptosis associated factor-1 (XAF1) as an IFN-stimulated proapoptotic gene. J. Biol. Chem. 277: 28504-28511. Pubmed
  5. Morrison, B. H., J. A. Bauer, J. Hu, R. W. Grane, A. M. Ozdemir, M. Chawla Sarkar, B. Gong, A. Almasan, D. V. Kalvakolanu and D. J. Lindner. 2002. Inositol hexakisphohate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene. 21: 1882-1889. Pubmed

2001

  1. Chawla Sarkar, M., D. W. Leaman and E. C. Borden. 2001. Preferential induction of apoptosis by IFN compared to IFN: Correlation with TRAIL/Apo2L induction in melanoma cell lines. Clinical Cancer Research. 7: 1821-1831. Pubmed

1999

  1. Chawla, M., and S. K. DasGupta. 1999. Transposition induced structural instability of E.coli - mycobacteria shuttle vectors. Plasmid. 41: 135-140. Pubmed

Book Chapters

  1. Kobayashi, M., M. Ishino, Y. H. Yang, M. Chawla Sarkar, T. Krishnan, T. N. Naik. 2007. Diversity of G-type-P-type of human and animal rotaviruses its genetic background, p. 847-858. In A-Mendez-Vilas (ed.), Communicating Current Research Educational Topics and Trends in Applied Micobiology. Formatex, Spain.
  2. Chawla Sarkar. M., P. Masci, and E. C. Borden. 2003. Interferons for cancer therapy: Key contributions of recombinant biotechnology, p. 161-179. In Ed Rodney, J. Y. Ho and M. Gibaldi (ed.), Biotechnology Biopharmaceuticals: Transforming Proteins and Genes into Drugs. J Wiley Sons Inc., New Jersey, USA.

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