National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. Hemanta Koley

Dr. Hemanta Koley

Field of Research:

His present research interest is to understand signal transduction pathways in immune and inflammatory cells during diarrhoea and also to study the nature of protection against diarrhoeal pathogens like Vibrio cholerae and Shigella in different animal model.

Educational Background:

After completion of his Master degree in Physiology from University College of Science & Technology, Calcutta University, he joined in National institute of Cholera and Enteric Diseases, Beliaghata, Calcutta for his Ph. D. degree under super guidance of Dr. GB Nair. In 1996, he joined as Associate Professor in Dept. Physiology, College of Medical Sciences-Nepal, where he devoted entire heartily in teaching medical students till 2001. In the mean time Dr. Koley got opportunity for Post Doctoral research at Dept of Physiology, Rutgers -The State University of New Jersey, New Brunswick, USA. After completion of one year in Rutgers University, Dr. Koley moved to Boston, joined in Gastroenterology Section, Harvard Medical School as Research Associate and worked there on "Molecular mechanism of Barrett's esophagus and to identify therapeutic target for Adenocarcinoma" under leadership of Prof. R K Goyal, renowned gastroenterologist.

Research Achievement:

He has published 34 original papers and 25 abstracts in his credit. He has secured patent for a process for the preparation of Cholera Vaccine-VA1.3 (European Patent Office; Patent No.- 97309957.5-2105 on 19/05/98). Dr. Koley received Young Scientist Award in IUPS International Congress, Christchurch, New Zealand, August 2001. Invited Oration Lecture: "Dr. ( Mrs.) Chitralekha Mukherjee Memorial Oration-2010" at St. John's Medical College, Bangalore on 16th December 2010

General Information
Name Dr. Hemanta Koley
Educational Qualification M.Sc., Ph.D.
Designation Scientist D
Division Bacteriology
Specialization Bacteriologist
Date of joining ICMR 1st October 2004
Email : hemantakoley@hotmail.com

Profile

Professional Experience

After completion of his Master degree in Physiology from University College of Science & Technology, Calcutta University, he joined in National institute of Cholera and Enteric Diseases, Beliaghata, Calcutta for his Ph. D. degree under guidance of Dr. GB Nair. In 1996, he joined as Associate Professor in Dept. Physiology, College of Medical Sciences-Nepal, where he devoted entire heartily in teaching medical students till 2001. In the mean time Dr. Koley got opportunity for Post Doctoral research at Dept of Physiology, Rutgers-The State University of New Jersey, New Brunswick, USA. After completion of one year in Rutgers University, Dr. Koley moved to Boston, joined in Gastroenterology Section, Harvard Medical School as Research Associate and worked there on "Molecular mechanism of Barrett's esophagus and to identify therapeutic target for adenocarcinoma" under leadership of Prof. R. K. Goyal, renowned gastroenterologist.

Research Interests

His present research interest is to understand signal transduction pathways in immune and inflammatory cells during diarrhoea and also to study the nature of protection against diarrhoeal pathogens like Vibrio cholerae, Shigella, Salmonella and Escherichia coli in different animal models.

Projects

Intramural

Principal Investigator:

  • Evaluation of immunogenicity and protective efficacy of ?tolAShigella OMVs in animal model. Intramural ongoing project
  • Studies on a novel approach of using outer membrane vesicles (OMVs) of Shigella as a candidate vaccine in animal models.Intramural project completed.
  • Studies on colonization ability of tcp-veVibrio cholerae strains in animal models. ICMR-Intramural Project completed

Co- Investigator:

  • Studies on the regulation antibacterial peptide expression and their role in mixed and opportunistic infection of the gut. Funded by Okayama University.
  • Gastrointestinal tract pathogens repository (GTPR). Funded by ICMR

Extramural

  • Development and evaluation of a heat killed multi-serotype oral Shigella vaccine- Japan Initiative for Global Research Network on Infectious Diseases (J-GRID), Ministry of Education, Culture, Sports, Science and Technology of Japan.
  • Development of shigella vaccine based on the virulence gene expression. Funded by Department of Bacteriology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.

Pre-doctoral Fellows

  • Mr. Dhrubajyoti Nag
  • Mr. Ritam Sinha
  • Ms. Priyadarshini Mukherjee
  • Mr. Debaki Ranjan Howlader

Ph. D Awarded Student:

  • Dr. Nivedita Ray
  • Dr. Soumik Barman
  • Dr. Soma Mitra

Awards

  • Young Scientist Award in IUPS International Congress 2001, Christchurch, New Zealand, August 26-31, 2001
  • Invited Lecture, UGC Sponsored National Seminar, Dept. of Physiology, Presidency College, Kolkata, 19th December, 2008.
  • Invited Oration Lecture: on "Dr. ( Mrs.) Chitralekha Mukherjee Memorial Oration-2010" at St. John's Medical College , Bangalore on 16th December 2010
  • JICA - Fellowship : Worked with Dr. Shinji Yamasaki , Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 Gakuen-cho, Nakaku, Sakai, Osaka Prefecture University, Osaka, Japan form 2007-09-19 to 2008-03-15

Memberships

National Membership:

  • Life member of Physiological Society of India
  • Life member of Indian Science Congress Association

International Membership:

  • International Brain Research Organization (IBRO), Great Britain. Membership No. 1895-IBRO

Foreign Membership:

  • International Brain Research Organization (IBRO), Great Britain. Membership No. 1895-IBRO

Book chapter:

  • Practical Note book: College of Medical Sciences-Nepal , Edition -2000
  • A concise note MEDICAL LABORATORY TWCHNOLOGY, 2nd Edition, 15 August 2009

Patent

  • Patent for a process for the preparation of Cholera Vaccine (European Patent Office; Patent No.- 97309957.5-2105 on 19/05/98)
  • Patent for a process for the isolation of a non-toxigenic Vibrio Cholerae strain. (European Patent Office; Patent No.- 97309957.5-2105 on 19/05/98
  • Patent application for: "A multiple outer membrane vesicles (MOMV) of Shigellae as a Novel Candidate vaccine" ICMR New Delhi. (Patent application no. 1652/Del/2013 dated 31.05.2013)

Publications

2016

  1. Mitra S, Sinha R, Mitobe J, Koley H. 2016. Development of a cost-effective vaccine candidate with outer membrane vesicles of a tolA-disrupted Shigellaboydii strain. Vaccine 34:1839-46. Pubmed
  2. Mondal A, Tapader R, Chatterjee NS, Ghosh A, Sinha R, Koley H, Saha DR, Chakrabarti MK, Wai SN, Pal A. 2016. Cytotoxic and inflammatory responses induced by outer membrane vesicle-associated biologically active proteases from Vibrio cholerae. Infect Immun. 84:1478-90. Pubmed
  3. Mukherjee P, Raychaudhuri S, Nag D, Sinha R, Howlader DR, Mukhopadhyay AK, Koley H. 2016. Evaluation of immunogenicity and protective efficacy of combination heat-killed immunogens from three entero-invasive bacteria in rabbit model. Immunobiology. 221:918-26. Pubmed
  4. Nag D, Koley H, Sinha R, Mukherjee P, Sarkar C, Withey JH, Gachhui R. 2016. Immunization of mice with a live transconjugantShigellahybrid strain induced Th1 and Th17 cell-mediated immune responses and confirmed passive protection against heterologous Shigellae. Scand J Immunol. 83:92-101. Pubmed
  5. Sinha R, Howlader DR, Mukherjee P, Rai S, Nag D, Koley H. 2016. Retinoic acid decreases the severity of Salmonella entericaserovarTyphimurium mediated gastroenteritis in a mouse model. Immunobiology. 221:839-44. Pubmed

2015

  1. Nag D, Sinha R, Mitra S, Barman S, Takeda Y, Shinoda S, Chakrabarti MK, Koley H. 2015. Heat killed multi-serotype Shigellaimmunogens induced humoral immunity and protection against heterologous challenge in rabbit model. Immunobiology.220:1275-83. Pubmed
  2. Jaiswal A, Sarkar S, Das P, Nandy S, Koley H, Sarkar B. 2015. Trends in the genomic epidemiology of Vibrio cholerae O1 isolated worldwide since 1961. Int J Antimicrob Agents 46:460-4. Pubmed
  3. Withey JH, Nag D, Plecha SC, Sinha R, Koley H. 2015. Conjugated linoleic acid reduces cholera toxin production in vitro and in vivo by inhibiting Vibrio choleraeToxT activity. Antimicrob Agents Chemother. 59:7471-6. Pubmed
  4. Sinha R, Koley H, Nag D, Mitra S, Mukhopadhyay AK, Chattopadhyay B. 2015 Pentavalent outer membrane vesicles of Vibrio cholerae induce adaptive immune response and protective efficacy in both adult and passive suckling mice models. Microbes Infect. Mar;17(3):215-27. Pubmed
  5. Bhattacharya D, Dey S, Kadam S, Kalal S, Jali S, Koley H, Sinha R, Nag D, Kholkute SD, Roy S. 2015 Isolation of NDM-1-producing multidrug-resistant Pseudomonas putida from a paediatric case of acute gastroenteritis, India. New Microbes New Infect. Feb 28;5:5-9. Pubmed
  6. Rajpara N, Kutar BM, Sinha R, Nag D, Koley H, Ramamurthy T, Bhardwaj AK. 2015 Role of integrons, plasmids and SXT elements in multidrug resistance of Vibrio cholerae and Providenciavermicola obtained from a clinical isolate of diarrhea. Front Microbiol. Feb 17;6:57. Pubmed

2014

  1. Mondal M, D Nag, H Koley, DR Saha, Chatterjee NS. 2014. The Vibrio choleraeExtracellular Chitinase ChiA2 Is Important for Survival and Pathogenesis in the Host Intestine. PLoS One. 9:e103119. Pubmed
  2. Kanungo S, B Sen, T Ramamurthy, D Sur, B Manna, GP Pazhani, G Chowdhury, P Jhunjhunwala, RK Nandy, HKoley, MK Bhattacharya, S Gupta, G Goel, B Dey, M T, GB Nair, A Ghosh, D Mahalanabis.2014.Safety and immunogenicity of a live oral recombinant cholera vaccine VA1.4: a randomized, placebo controlled trial in healthy adults in a cholera endemic area in Kolkata, India. PLoS One. 9:e99381). Pubmed
  3. Barman S, H Koley, D Nag, S Shinoda, GB Nair, Y Takeda. 2014. Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice. MicrobiolImmunol. 58:463-6. Pubmed
  4. Koley H, N Ray, G Chowdhury, S Barman, S Mitra, T Ramamurthy, AK Mukhopadhyay, BL Sarkar, R Katyal, P Das, S Panda, S Ghosh.2014. Outbreak of cholera caused by Vibrio cholerae O1 El Tor variant strain in Bihar, India. Jpn J Infect Dis.67:221-6. Pubmed
  5. Jaiswal A, H. Koley, S Mitra, DR Saha, B Sarkar. 2014.Comparative analysis of different oral approaches to treat Vibrio cholerae infection in adult mice. Int J Med Microbiol. 304:422-30. Pubmed
  6. Ghosh P, A Naha, S Basak, S Ghosh, T Ramamurthy, H. Koley, RK Nandy, S Shinoda, H Watanabe, AK Mukhopadhyay. 2014. Haitian variant tcpA in Vibrio cholerae O1 El Tor strains in Kolkata, India. J ClinMicrobiol.52:1020-1. Pubmed

2013

  1. Mitra S, MK Chakrabarti, H. Koley 2013 Multi-serotype outer membrane vesicles of Shigellae confer passive protection to the neonatal mice against shigellosis. Vaccine. 31: 3163-3173 Pubmed
  2. Sheikh IA, H. Koley, MK Chakrabarti, KM Hoque. 2013 The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 288: 20404-20415. Pubmed
  3. Das P, AK Singh, S Mukherjee, K Rajendran, DR Saha, H. Koley, S Basu. 2013 Composition of Escherichia coli population in the neonatal gut: phylogroups and virulence determinants. J Med Microbiol. 62: 1680-1687. Pubmed
  4. Mukherjee S, H. Koley, S Barman, S Mitra, S Datta, S Ghosh, D Paul, P Dhar. 2013 Oxalis corniculata (Oxalidaceae) leaf extract exerts in vitro antimicrobial and in vivo anticolonizing activities against Shigella dysenteriae 1 (NT4907) and Shigella flexneri 2a (2457T) in induced diarrhea in suckling mice. J Med Food. 16: 801-809 Pubmed
  5. Barman S, H. Koley, T Ramamurthy, MK Chakrabarti, S Shinoda, GB Nair, Y Takeda. 2013 Protective immunity by oral immunization with heat-killed Shigella strains in a guinea pig colitis model. Microbiol Immunol. 57: 762-771. Pubmed
  6. Rajpara N, K Vinothkumar, P Mohanty, AK Singh, R Singh, R Sinha, D Nag, H. Koley, A Kushwaha Bhardwaj. 2013 Synergistic Effect of Various Virulence Factors Leading to High Toxicity of Environmental V. cholerae Non-O1/ Non-O139 Isolates Lacking ctx Gene : Comparative Study with Clinical Strains. PLoS One. 8: e76200. Pubmed
  7. DR Saha, S Guin, R Krishnan, D Nag, H. Koley, S Shinoda, T Ramamurthy. 2013 Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. Gut Pathog. 5: 36. Pubmed
  8. Jaiswal A, H. Koley, A Ghosh, A Palit, B Sarkar 2013 Efficacy of cocktail phage therapy in treating Vibrio cholerae infection in rabbit model. Microbes Infect. 15: 152-156. Pubmed

2012

  1. Mitra S, DR Saha, A Pal, Niyogi SK, U Mitra, H. Koley. 2012 Hemagglutinating activity is directly correlated with colonization ability of shigellae in suckling mouse model. Can J Microbiol. 58: 1159-1166. Pubmed
  2. Mitra S, S Barman, D Nag, R Sinha, DR Saha, H. Koley. 2012 Outer membrane vesicles of Shigella boydii type 4 induce passive immunity in neonatal mice. FEMS Immunol Med Microbiol. 66: 240-250. Pubmed
  3. China R, S Mukherjee, S Sen, S Bose, S Datta, H. Koley, S Ghosh, P Dhar. 2012 Antimicrobial activity of Sesbania grandiflora flower polyphenol extracts on some pathogenic bacteria and growth stimulatory effect on the probiotic organism Lactobacillus acidophilus. Microbiol Res. 167: 500-506. Pubmed
  4. Patra T, H. Koley, T Ramamurthy, AC Ghose, RK Nandy. 2012 The Entner-Doudoroff pathway is obligatory for gluconate utilization and contributes to the pathogenicity of Vibrio cholerae. J Bacteriol. 194: 3377-3385. Pubmed
  5. Dey T K , S. Ghosh , M. Ghosh, H. Koley, P. Dhar 2012
    Comparative study of gastrointestinal absorption of EPA DHA rich fish oil from nano and conventional emulsion formulation in rats. Food Research International , 49: 72-79

2011

  1. Barman S, DR Saha, T Ramamurthy, H. Koley. 2011 Development of a new guinea-pig model of shigellosis. FEMS Immunol Med Microbiol. 62: 304-314. Pubmed
  2. Barman S, R Kumar, G Chowdhury, DR Saha, T Wajima, T Hamabata, R Tamamurthy, GB Nair, Y Takeda, H. Koley. 2011 A live noninvasive Shigella dysenteriae 1 strain induces homologous protective immunity in a guinea pig colitis model. Microbiol Immunol. 55, 683-693. Pubmed
  3. Mukherjee, Chaki S. Barman S., S Das., H. Koley and Dastidar Ghosh, 2011 Effective elimination of drug resistance genes in pathogenic Pseudomonas aeruginosa by antipsycholic agent thioridazine . Current Research in Bacteriology
  4. Ghosh S, Chakraborty K, Nagaraja T, Basak S, Koley H , Dutta S, Mitra U, Das S. 2011. An adhesion protein of Salmonella enterica serovar Typhi is required for pathogenesis and potential target for vaccine development. Proc Natl Acad Sci USA 108: 3348-3353. Pubmed
  5. Panda S, Pati KK, Bhattacharya MK, Koley H, Pahari S, Nair GB. 2011 Rapid situation response assessment of diarrhea outbreak in a coastal district following tropical cyclone AILA in India. Indian J Med Res. 133: 395-400. Pubmed

2010

  1. Roy, N., S Barman, A Ghosh, A Pal, K Chakraborty, SS Das, DR Saha, S Yamasaki, H. Koley. 2010. Immunogenicity and protective efficacy of Vibrio cholerae outer membrane vesicles in rabbit model. FEMS Immunol Med Microbiol. 60: 18-27. Pubmed
  2. Barman, S., S Chatterjee, G Chowdhury, T Ramamurthy, SK Niyogi, R Kumar, H. Koley 2010. Plasmid-mediated streptomycin and sulfamethoxazole resistance in Shigella flexneri 3a. Int J Antimicrob Agents. 36: 348-351. Pubmed
  3. Ghosh-Banerjee, J., M Senoh, T Takahashi, T Hamabata, S Barman, H. Koley, Mukhopadhyay AK, Ramamurthy T, Chatterjee S, Asakura M, Yamasaki S, Nair GB,Takeda Y. 2010 . Cholera toxin production by the El Tor variant of Vibrio cholerae O1compared to prototype El Tor and classical biotypes. J Clin Microbiol.48: 4283-6. Pubmed
  4. Syngkon A, S Elluri, H. Koley, P K Rompikuntal, DR Saha, MK Chakrabarti, RK Bhadra , SN Wai, A Pal. 2010 Studies on a novel serine protease of a ?hapA?prtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit ileal loop model. PLoS One. 5(9). e13122. Pubmed

2009

  1. Shammas, M. A., Shmookler Reis RJ, H. Koley, Batchu RB, Li C, Munshi NC. 2009. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 113: 2290-7. Pubmed
  2. Bhowmick, T.S., H. Koley, M. Das, D. R. Saha, B. L. Sarkar. 2009. Pathogenic potential of vibriophages against an experimental infection with Vibrio cholerae O1 in the RITARD model. Int J Antimicrob Agents. 33: 569-573. Pubmed
  3. Koley, H., S. Barman, N. Roy, D. R. Saha, R. Kumar. 2009. The efficacy and immunogenicity of a live transconjugant hybrid strain of Shigella dysenteriae type 1 in two animal models. World J. Microbiol Biotechnol. 25: 679-686. Pubmed

2008

  1. Chakraborty, K., Ghosh S, H. Koley, Mukhopadhyay AK, Ramamurthy T, Saha DR, Mukhopadhyay D, Roychowdhury S, Hamabata T, Takeda Y, Das S. 2008. Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human beta-defensin 1 (HBD-1) expression in the intestinal epithelial cells. Cell Microbiol. ;10: 2520-37. Pubmed
  2. Banerjee, S., Chattopadhyay R, Ghosh A, H. Koley, Panda K, Roy S, Chattopadhyay D, Chatterjee IB. 2008 .Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C. J Inflamm 11; 5: 21. Pubmed
  3. Shammas, M. A., H. Koley, R. C. Bertheau, P. Neri, M. Fulciniti, P. Tassone, S. Blotta, A. Protopopov, C. Mitsiades, R. B. Batchu, K. C. Anderson, A. Chin, S. Gryaznov, N. C. Munshi. 2008. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia. 22:1410-8. Pubmed
  4. Koley, H., Soumik Barman, N. Roy, D. R. Saha, R. Kumar. 2008. The efficacy and immunogenicity of a live transconjugant hybrid strain of Shigella dysenteriae type 1 in two animal models. World J. Microbiol Biotechnol. 25: 679-686.
  5. Bhowmick, R., A. Ghosal, B. Das, H. Koley, D. R. Saha, S. Ganguly, R. K. Nandy, R. K. Bhadra, N. S. Chatterjee. 2008 Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization factor GbpA and mucin. Infect Immun. 76: 4968-77. Pubmed

2006

  1. Shammas, M. A., P. Neri, H. Koley, R. B. Batchu, R. C. Bertheau, V. Munshi, R. Prabhala, M. Fulciniti, Y. T. Tai, S. P. Treon, R. K. Goyal, K. C. Anderson, N. C. Munshi. 2006. Specific killing of multiple myeloma cells by (-) epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications. Blood. 108: 2804-10. Pubmed
  2. Ghosh, A., D. R. Saha, K. M. Hoque, M. Asakuna, S. Yamasaki, H. Koley, S. S. Das, M. K. Chakrabarti, A. Pal. 2006. Enterotoxigenicity of mature 45-kilodalton and processed 35-kilodalton forms of hemagglutinin protease purified from a cholera toxin gene-negative Vibrio cholerae non-O1, non-O139 strain. Infect Immun. 74: 2937-46. Pubmed

2005

  1. Shammas, M. A., H. Koley, R. B. Batchu, R. C. Bertheau, A. Protopopov, N. C. Munshi, R. K. Goyal. 2005. Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. Mol. Cancer. 15: 4-24. Pubmed

2004

  1. Koley, H., M. A. Shammas, D. G. Beer, C. Li, R. K. Goyal, N. C. Munshi. 2004. Growth arrest, apoptosis and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 126: 1337-46. Pubmed
  2. Shammas, M. A., Reis R. J. Shmookler, C. Li, H. Koley, L. H. Hurley, K. C. Anderson, N. C. Munshi. 2004 Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res. 10: 770-6. Pubmed

2003

  1. Shammas, M. A., Reis R. J. Shmookler, M. Akiyama, H. Koley, D. Chauhan, T. Hideshima, R. K. Goyal, L. H. Hurley, K. C. Anderson, N. C. Munshi. 2003. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther. 2: 825-33. Pubmed

2002

  1. Shammas, M. A., H. Koley, R. K. Goyal and C. Nikhil. Munshi. 2002. Telomerase Inhibition and apoptotic cell growth arrest following telomestain treatment of multiple myeloma. Blood: 100, 11 810-15.

1999

  1. Thungapatra, M., C. Sharma, N. Gupta, R. K. Ghosh, A. Mukherjee, H. Koley, G. B. Nair and A. Ghosh. 1999. Construction of a recombinant live oral vaccine from a non-toxigenic strain in of V.cholerae O1 serotype Inaba biotype El Tor and assessment of its reactogenicity and immunogenicity in the rabbit model. Immunology Letter. 68: 219 -227. Pubmed
  2. Koley, H., Rupak Mitra, Arnab Basu, Asish K. Mukhopadhyay, P. K. Saha, B. S. Ramakrisha, Selvi Krishnan, Yoshifumi Takeda and G. Balakrish Nair. 1999. Response of Wild-type Mutants of Vibrio cholerae 01 possessing different combinations of Virulence zenes in the Ligated Rabbit Ileal Loop and in Ussing chambers: Evidence for the presence of additional secretogen. J. Med. Microbiol. 48: 51-57. Pubmed

1997

  1. Bhattacharya, S. K., M. K. Bhattacharya, D. Dutta, S. Dutta, M. Deb, A. Deb, A. G. Goswami, K .P. Das, H. Koley, G. B. Nair and A. Bagati. 1997 Double-blind, randomized clinical trial for safety and efficacy of Norfloxacin for shigellosis in children. Acta Paediatrica. 86: 319-320. Pubmed
  2. Saha, D. R., H. Koley, A. N. Ghosh and G. B. Nair. 1997. Sequential changes in gut mucosa of rabbits infected with Vibrio cholerae 0139 Bengal: an Ultrastructureal Study. J. Diarrhoeal. Dis. Res. 15: 59-64. Pubmed

1996

  1. Saha, P., H. Koley and G. B. Nair. 1996 Purification and Characterization of an extra cellular secretogenic non-membrane damaging cytotoxin produce by clinical strain of V.cholerae Non-01. Infection Immunity. 64: 3101-3108. Pubmed
  2. Saha, P., H. Koley, A. Mukherjee, S. K. Bhattacharya, G. B. Nair, B. S. Ramakrishna, S. Krishnan, Y. Takeda, 1996. Nontoxigenic Vibrio cholerae 01 Serotype Inaba Biotype EIT or Associated with a Cluster of Cased of Cholera in Southern India. Journal of Clinical Microbiology. 34: 1114-1117. Pubmed
  3. Sarkar, B. L., A. K. Chakrabarty, H. Koley, M. K. Chakrabarty and S. P. Dey. 1996. Biological activity and interaction of Vibrio cholerae bacteriopheges in rabbit ileal loop. Indian Journal of Medical Research. 104: 139-141. Pubmed
  4. Ghosh, A. R., M. Paul, H. Koley, S. K. Bhattacharya and G. B. Nair. 1996. Emergence of Shigella species in India. Lab. Medica. International. 5: 18-24.
  5. Ghosh, A. R., H. Koley, D. De, M. Paul, G. B. Nair and D. Sen. 1996. ETEC associated diarrhea among infants aged less than six months in Calcutta, India. European Journal of Epidemiology. 12: 81-84. Pubmed

1995

  1. Koley, H., A. N. Ghosh, M. Paul, A. R. Ghosh, P. K. Ganguly and G. B. Nair. 1995. Colonization ability and intestinal pathology of rabbits orally fed with Vibrio cholerae 0139 Bengal. Ind. J. Med. Res. 101: 57-60. Pubmed

1994

  1. Bhattacharya, M. K., S. K. Bhattacharya, M. Paul, D. Dutta, P. Dutta, H. Koley, D. De, A. R. Ghosh, P. Das and G. B. Nair. 1994. Shigellosis in Calcutta during 1990-1992. Antibiotic susceptibility pattern and clinical feature. J. Diarrhoeal Dis. Res. 12: 121-124. Pubmed
  2. Ghosh, A. R., H. Koley, D. De, S. Garg, M. K. Bhattacharya, S. K. Bhattacharya, G. B. Nair, T. Shimada, T. Takeda and Y. Takeda. 1994. Incidence and toxigenicity of Vibrio cholerae in a freshwater lake during the epidemic of cholera caused by serogroup O139 Bengal in Calcutta, India. FEMS Microbiol. Ecol. 14: 285-292.

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