National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. Shanta Dutta

Dr. Tapas Biswas

Dr. Tapas Biswas joined NICED on September 11, 1989 after completing his post doctoral research at NIH, USA. Presently, he is working to understand how bacterial molecules signal to display heightened immunity and under certain conditions, apoptosis. Mostly, the studies are directed to dissect the mechanism of gut immunity in which bacterial molecules would suffice as adjuvants.

So far he has published over 40 papers in peer reviewed journals, mentored 9 Ph. D thesis and reviewed manuscripts for several leading immunology journals.

General Information
Name Dr. Tapas Biswas
Educational Qualification M.Sc., Ph.D.
Designation Scientist G
Division Immunology
Specialization Immunologist
Date of joining ICMR 11th September 1989
Email : shigellaporin@yahoo.com

Profile

Professional Experience

Biochemical, cellular and molecular immunology.

Served as invited reviewer for the following journals: The Journal of Immunology (2009 & 2014); European Journal of Immunology (2008, 2009a & 2009b); Journal of Leukocyte Biology (2010, 2011 & 2016), Infection and Immunity (2013 & 2014), Clinical and Experimental Immunology (2008); Microbes and Infection (2007); Journal of Infection (2007); Microbial Pathogenesis (2008); Innate Immunity (2008); Indian Journal of Medical Research (2013); World Journal of Gastroenterology (2014); Mucosal Immunology (2016).

Member (2012-2014): Task Force on Infectious Disease Biology, Department of Biotechnology, Government of India, New Delhi.

Research Interests

Toll-like receptor mediated regulation of mucosal immune response to establish porin of Shigella dysenteriae as an adjuvant

Differential regulation of antigen-presenting cells by Vibrio cholerae hemolysin and its oligomer

Projects

Intramural

  • Cytokine Regulation of Porin Stimulated B-1a Cell

Extramural

  • Department of Science and Technology (New Delhi) project: The candidate successfully completed work as the Principal Investigator of the DST sponsored project "Porin of Shigella dysenteriae Mediated Regulation of Toll-Like Receptor and Costimulatory Molecule on Mouse Mucosal Macrophage and B Cell Subsets, and Induction of Immunoglobulin and Interleukin," from February 23, 2005 to February 22, 2008.
  • Department of Biotechnology (New Delhi) project: Served as the Principal Investigator of the DBT sponsored project "Regulation of Mucosal Immune Response by Synthetic Peptides of Porin: A Candidate Adjuvant," September 12, 2006-March 31, 2009.
  • DST (New Delhi) project: Principal Investigator of the DST sponsored project "Presentation of Shigella-Porin by Dendritic Cell to CD3+ CD4+ Cell for the T Helper Activation, Differentiation and Generation of the Adjuvant-Specific Memory Cells", November 4, 2009-November 3, 2012.
  • DBT (New Delhi) project: The candidate is the Principal Investigator of the DBT sponsored project "Generation of Culture-differentiated Innate Memory CD8 Cells with Toll-like Receptor Expression and Responsiveness to Pathogen/Danger-associated Molecules," from May 2014 to date.

Pre-doctoral and Post-doctoral Students

Pre-doctoral Students

  • Dr. Sudipta Roy
  • Biochemical and Immunological Studies of Major Outer Membrane Protein with Pore-Forming Ability of Shigella dysenteriae Type 1

    Visva-Bharati 1995

  • Dr. Avijit Ray
  • Regulation of Mucosal Immune Response by Porin of Shigella dysenteriae Type 1

    Jadavpur University 2005

  • Dr. Amlan Biswas
  • Activation and Response of Peritoneal Macrophage for T Cell Polarization by Porin of Shigella dysenteriae Type 1

    Jadavpur University 2008

  • Dr. Gayatri Mukherjee
  • Differential Regulation of B-1a Cell by Vibrio cholerae Hemolysin and Its Oligomer

    Jadavpur University 2008

  • Dr. Pallavi Banerjee
  • Maturation of Dendritic Cell by Shigella Porin Incorporated Liposome for T Cell Differentiation and Response

    Jadavpur University 2009

  • Dr. Deep Chandan Chakraborty
  • Apoptosis and Activation: Dual Fate of Peritoneal Macrophages in Response to Vibrio cholerae Hemolysin

    Jadavpur University 2013

  • Dr. Subhadeep Mukherjee
  • Porin-induced Toll-like Receptor Signaling of Colonic Epithelial Cells for Chemokine and Cytokine Expression to Facilitate Cross-talk with Immune Cells

    Jadavpur University 2015

  • Dr. Debolina Sinha
  • Porin Differentially Regulates Cytokine Expression of Follicular Zone and Marginal Zone B Cells

    Jadavpur University 2016

  • Dr. Amlan Kanti Ghosh
  • Regulation of B-1a Cells by Interleukin-15 for Mucosal Immune Response

    Jadavpur University 2017

Research Scientist

  • Dr. Ratna Biswas, DBT

Memberships

  • Visiting Fellow (Post Doctoral) at National Institutes of Health, Bethesda, Maryland, USA, 1984-1987
  • Visiting Associate at National Institutes of Health, USA, 1987-1988
  • Counterpart JICA participant at International Medical Center of Japan, Tokyo, Japan, August 22, 2000-February 16, 2001

Publications

2017

  1. Ghosh, A. K., Sinha, D., Biswas, R. and Biswas, T. 2017. IL-15 stimulates NKG2D while promoting IgM expression of B-1a cells. Cytokine 95: 43-50.

2016

  1. Ghosh, A. K., Sinha, D., Biswas, R. and Biswas, T. 2016. Pathogen-associated porin turns IL-10 competent B-1a cells toward proinflammatory cytokine response. Immunobiology 221: 1369-1373. Pubmed
  2. Ghosh, A.K., Sinha, D., Mukherjee, S., Biswas, R. and Biswas, T. 2016. IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression. Cell. Mol. Immunol. 13: 229-239.

2015

  1. Ghosh, A.K., Sinha, D., Mukherjee, S., Biswas, R. and Biswas, T. 2015. LPS stimulates and Hsp70 down-regulates TLR4 to orchestrate differential cytokine response of culture-differentiated innate memory CD8+ T cells. Cytokine 73: 44-52. Pubmed
  2. Sinha, D., A. K. Ghosh, S. Mukherjee, R. Biswas, T. Biswas. 2015. Porin differentiates TLR mediated proinflammatory response of follicular zone B cell from TLR-unresponsive IL-10 expressing marginal zone B cell. Cytokine 76(2): 193-205. Pubmed

2014

  1. Mukherjee, S., and T. Biswas. 2014. Activation of TOLLIP by porin prevents TLR2-associated IFN-? and TNF-a-induced apoptosis of intestinal epithelial cells. Cell. Signal. 26: 2674-2682. Pubmed
  2. Sinha, D., A. K. Ghosh, S. Mukherjee, R. Biswas, and T. Biswas. 2014. Antigenic relatedness defines Toll-like receptor 2 is crafted on ligand blueprint. Immunobiology 219:798-801. Pubmed
  3. Mukherjee, S., D. Sinha, A. K. Ghosh, and T. Biswas. 2014. Bacterial ligand stimulates TLR2-dependent chemokines of colon cell. Immunobiology 219:350-356. Pubmed
  4. Biswas, R., S. Mukherjee, D. Sinha, A. K. Ghosh, and T. Biswas. 2014. Culture-differentiated CD8+ T cells acquire innate memory-like traits and respond to a pathogen-associated molecule. Immunol. Cell Biol. 92: 368-376. Pubmed

2013

  1. Mukherjee, S., R. Biswas, and T. Biswas. 2013. Alternative TLRs are stimulated by bacterial ligand to induce TLR2-unresponsive colon cell response. Cell. Signal. 25: 1678-1688. Pubmed

2011

  1. Chakraborty, D. C., G. Mukherjee, P. Banerjee, K. K. Banerjee and T. Biswas. 2011 Hemolysin Induces Toll-like Receptor (TLR)-independent Apoptosis and Multiple TLR-associated Parallel Activation of Macrophages. J. Biol. Chem. 286: 34542-34551. Pubmed

2010

  1. Mukherjee, D., A. Biswas, S. Bhadra, V. Pichairajan, T. Biswas, B. P. Saha and P. K. Mukherjee. 2010. Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules. Immunopharmacol. Immunotoxicol. 32: 466-472. Pubmed
  2. Paul, S., A. Biswas, K. Sasmal, S. Mukherjee, T. Biswas and R. Biswas. 2010. IL-10 alters prolactin receptor activity emulating that during breast cancer. Cytokine 51:144-150. Pubmed

2009

  1. Biswas, A., P. Banerjee, and T. Biswas. 2009. Porin of Shigella dysenteriae directly promotes Toll-like receptor 2-mediated CD4+ T cell survival and effector function. Mol. Immunol. 46: 3076-3085. Pubmed

2008

  1. Banerjee, P., A. Biswas and T. Biswas. 2008. Porin-incorporated liposome induces Toll-like receptors 2- and 6-dependent maturation and type 1 response of dendritic cell. Int. Immunol. 20: 1551-1563. Pubmed
  2. Mukherjee, G., K. K. Banerjee and T. Biswas. 2008. Oligomerization of Vibrio cholerae hemolysin induces CXCR3 upregulation and activation of B-1a cell. Cell. Mol. Immunol. 5: 231-234. Pubmed
  3. Biswas, A., P. Banerjee and T. Biswas. 2008. Priming of CD4+ T cells with porin of Shigella dysenteriae activates the cells toward type 1 polarization. Int. Immunol. 20: 81-88. Pubmed
  4. Mukherjee, G., A. Biswas, K. K. Banerjee and T. Biswas.2008. Vibrio cholerae hemolysin is apoptogenic to peritoneal B-1a cells but its oligomer shepherd the cells for IgA response. Mol. Immunol. 45: 266-270. Pubmed

2007

  1. Biswas, A., P. Banerjee, G. Mukherjee and T. Biswas. 2007. Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response. Mol. Immunol. 44: 812-820. Pubmed

2005

  1. Ray, A., and T. Biswas. 2005. Porin of Shigella dysenteriae enhances Toll-like receptors 2 and 6 of mouse peritoneal B-2 cells and induces the expression of immunoglobulin M, immunoglobulin G2a and immunoglobulin A. Immunology. 114: 94-100. Pubmed

2004

  1. Ray, A., P. Karmakar and T. Biswas. 2004. Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent. Mol. Immunol. 41: 1167-1175. Pubmed

2003

  1. Ray, A., K. Chattopadhyay, K. K. Banerjee and T. Biswas.2003. Macrophage distinguishes Vibrio cholerae hemolysin from its protease insensitive oligomer by time dependent and selective expression of CD80-CD86. Immunol. Lett. 89: 143-147. Pubmed
  2. Ray, A., N. S. Chatterjee, S. K. Bhattacharya and T. Biswas. 2003. Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88, up-regulates CD80 of murine macrophage, and induces the release of interleukin-12. FEMS Immunol. Med. Microbiol. 39: 213-219. Pubmed

2000

  1. Biswas, T., 2000. Role of porin of Shigella dysenteriae type 1 in modulation of lipopolysaccharide mediated nitric oxide and interleukin-1 release by murine peritoneal macrophages. FEMS Immunol. Med. Microbiol. 29: 129-136. Pubmed

1996

  1. Roy, S., and T. Biswas. 1996. Murine splenocyte proliferation by porin of Shigella dysenteriae type 1 and inhibition of bacterial invasion of HeLa cell by anti-porin antibody. FEMS Microbiol. Lett. 141: 25-29. Pubmed

1995

  1. Biswas, T., S. Roy and K. K. Banerjee. 1995. L-rhamnose inhibits proliferation of murine splenocyte by lipopolysaccharide and polysaccharide moiety of lipopolysaccharide of Shigella dysenteriae type 1. Immunology.  84: 322-325. Pubmed

1994

  1. Roy, S., A. B. Das, A. N. Ghosh and T. Biswas. 1994. Purification, pore-forming ability and antigenic relatedness of major outer membrane protein of Shigella dysenteriae type 1. Infect. Immun. 62: 4333-4338. Pubmed
  2. Roy, S., A. B. Das and T. Biswas. 1994. Antigenicity and antigenic relatedness of the outer membrane proteins of Shigella species. Microbios. 79: 55-64. Pubmed
  3. Biswas, T., and M. K. Chakrabarti. 1994. Antigenicity and antigenic cross reactivity of outer membrane proteins of Vibrio parahaemolyticus. Int. J. Med. Microbiol. 281: 475-480. Pubmed

1993

  1. Biswas, T., M. K. Chakrabarti, M. K. Bhattacharya, D. Sen and S. K. Bhattacharya. 1993. Antigenicity and cross reactivity of sarkosyl soluble envelope (inner membrane proteins) of Shigellaflexnari 2a as recognised by human antibodies. Biomedical Lett. 48: 229-234

1991

  1. Chakrabarti, M. K., A. K. Sinha and T. Biswas. 1991. Adherence of Vibrio parahaemolyticus to rabbit intestinal epithelial cells in vitro. FEMS Microbiol. Lett. 84: 113-118. Pubmed
  2. Bhadra, R. K., T. Biswas, S. C. Pal, T. Takeda and G. B. Nair. 1991. A polyclonal-monoclonal antibody based sensitive sandwich enzyme-linked immunosorbent assay for specific detection of cholera toxin. Int. J. Med. Microbiol. 275: 467-473. Pubmed

1990

  1. Miller, F. W., K. A. Waite, T. Biswas and P. H. Plotz. 1990. The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity. Proc. Natl. Acad. Sci. (USA).87: 9933-9937. Pubmed
  2. Miller, F. W., S. A. Twitty, T. Biswas and P. H. Plotz. 1990. The origin and regulation of a disease-specific autoantibody response: antigenic epitopes, spectrotype stability and isotype restriction of anti-Jo-1 autoantibodies. J. Clin. Invest. 85: 468-475 Pubmed

1988

  1. Biswas, T., F. W. Miller and P. H. Plotz. 1988. Stimulation and partial stabilization of human histidyl-tRNA synthetase by hemoglobin. FEBS Lett. 229: 203-205. Pubmed

1987

  1. Biswas, T., F. W. Miller, Y. Takagaki and P. H. Plotz. 1987. An enzyme-linked immunosorbent assay for the detection and quantitation of anti-Jo-1 antibody in human serum. J. Immunol. Methods. 98: 243-248. Pubmed
  2. Biswas, T., F. W. Miller, S. A. Twitty and P. H. Plotz. 1987. An efficient method for enrichment of histidyl-tRNA synthetase (Jo-1 antigen) from HeLa cells. J. Immunol. Methods. 98: 235-241. Pubmed
  3. Miller, F. W., L. A. Love, T. Biswas, P. R. McClintock, A. L. Notkins and P. H. Plotz. 1987. Viral and host genetic factors influence encephalomyocarditis virus-induced polymyositis in adult mice. Arthritis Rheum. 30: 549-556. Pubmed

1985

  1. Biswas, T., A. Lahiri Majumder, A. Lahiri Majumder and K. L. Mukherjee. 1985. Fructose-1, 6-bisphosphatase: Part IV-Characterization of the enzyme from developing human fetal brain.Indian J. Biochem. Biophys. 22: 355-359. Pubmed
  2. Biswas, T., A. Lahiri Majumder, A. Lahiri Majumder and K. L. Mukherjee. 1985. Fructose-1, 6-bisphosphatase: Part III-Characterization of the enzyme from developing human fetal liver.Indian J. Biochem. Biophys. 22: 350-354. Pubmed

1982

  1. Biswas, T., A. Lahiri Majumder, G. Guha Thakurta and K. L. Mukherjee. 1982. Fructose-1, 6-bisphosphatase in human fetal brain and liver during development. J. Biosci. 4: 167-173.

1981

  1. Biswas, T., J. Adhikari, R. Biswas Choudhury and A. Lahiri Majumder. 1981. Fructose-1, 6-bisphosphatase and myo-inositol synthase: A phylogenetic search. Indian J. Biochem. Biophys. 18: 442-444. Pubmed

Book chapter

  1. Biswas, T., and A. Ray. 2005. Activation of peritoneal macrophage and B cell subsets by porin of Shigella dysenteriae type 1 for mucosal immune response, In: Progress in Immunology Research (Ed: B.A. Veskler), pp. 231-247, Nova Science Publishers Inc., New York..

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