National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. Sandipan Ganguly

Dr. Sandipan Ganguly

Dr. Sandipan Ganguly is the Senior Research Officer in Division of Parasitology. Previously he was a Post Doctoral Faculty in Saint Louis University School of Medicine for two years. He is a Chemistry Major (1996) and Biochemistry post graduate (1998) from University of Calcutta. Dr. Ganguly has acquired his PhD degree also from University of Calcutta and has joined NICED in 2005.

His publications include many scientific papers in renowned International journals, one cover page photograph and one book chapter. He has attended more than 17 National and 15 International symposiums and workshops and presented papers on various infectious diseases issues.

Dr. Ganguly has been working on various aspects of enteric parasitology with special emphasis on molecular and cellular aspects of pathogenesity in these parasites. His major present focus is on the molecular analyses of rRNA biogenesis, mechanism of its formation and its use as a drug target in Giardiasis. Study the effects of oxidative stress on microaerophilic Giardia at its cellular, genome, proteome and metabolomic level, molecular diagnosis of enteric parasites, molecular epidemiology of Coccisides and other enteric parasites in immunocompromized patients. He has visited Gunma University, Keio University, Tokai University and Okayama University, Japan under JICA training program in 2007 and National Institute of Health, Bethesda, Maryland, USA in 2008.

He is an invited lecturer and paper setter and examiner in several Universities like Departments of Microbiology, Zoology, Environmental sciences, Calcutta University. West Bengal University of Technology. Guide for PhD students from University of Calcutta, Utkal University, Jadavpur University. He is a member of The Indian Science Congress Association, Society for Biological Chemists, India, Indian Society for Parasitology, India and Immunology study group, West Bengal, India.

He has achieved several prestigious awards of National and International repute including the Young Scientist Award (2003) from International Union of Biochemistry and Molecular Biology (IUBMB) and presented his work during 2nd Human Proteomics and 19th International Congress of Biochemistry and Molecular Biology in Montreal, Canada. Dr. Ganguly has been awarded by DST Fast track Young Scientist Award (2005-2006) from Department of Science and Technology, Govt. of India and Sir Sriram Award (2007-2008) from National Academy of Medical Sciences, India. He has also been awarded by the Best Poster Award in 15th National Congress of Parasitology, in 2001 at Jodhpur, India and Best Poster Award in Frontiers in Molecular Biology in 2003 at Kolkata.

Dr. Ganguly is an invited expert to deliver radio talks in All India Radio on topics of public interest in infectious gastrointestinal diseases. He has conducted several training programs and workshops including CDC International workshop on diarrheal parasites (2008) for doctors and researchers. He has attended several training courses in molecular biology, immunology, cell biology, biotechnology and bioinformatics and participated in several investigations on infectious diseases and parasitic diarrhea. He is an invited reviewer of National and International journals like Parasitology International.

General Information
Name Dr. Sandipan Ganguly
Educational Qualification M.Sc., Ph.D.
Designation Scientist E
Division Parasitology
Specialization Molecular Biology
Date of joining ICMR 19th October 2005
Email : gangulys@icmr.org.in , sandipanganguly@hotmail.com

Profile

Professional Experience

  • B.Sc. (Hons) from University of Calcutta in Chemistry, 1996
  • M.Sc. from University of Calcutta in Biochemistry, 1998
  • PhD from University of Calcutta in 2004. Thesis topic: Studies on snRNA and ribosome biogenesis in Giardia lamblia"
  • Post Doctoral Research Faculty at Department of Pathology, Saint Louis University School of Medicine, Missouri, USA. 2004 - 2005. Research topic: Studies on snRNA and ribosome biogenesis
  • Visiting scientist in Gunma University School of Medicine, Gunma, Japan Jul, 2007-Jan, 2008. Research Topic: Ribosome biogenesis and oxidative stress regulation in Entamoeba histolytica and Giardia lamblia
  • Research training on axenization of enteric parasites in Keio University, Japan, 2008
  • Oct 2005 till date working as Senior Research Officer, Department of Parasitology, National Institute of Cholera and Enteric Diseases, Kolkata, ICMR, India
  • Invited lecturer: MSc, Microbiology, University of Calcutta on Molecular Parasitology
  • Invited lecturer: West Bengal University of Technology , Bangabasi College, Dinabandhu Andrews College, Asutosh College.

Research Interests

The main focus of this lab is to study on different molecular and cellular aspects of biochemistry in enteric parasites. This can easily be exploited as a target for rational drug designing in different systems. Studies on these aspects will be useful in future for fighting against very primitive but extant gastrointestinal disease like giardiasis, amoebiasis etc.

  • Molecular genomics and structural analysis of RNA and proteins in snRNPs.
  • Molecular cell biology of macromolecular interactions.
  • Ribosome biogenesis in parasites.
  • Transcriptomics, proteomics and metabolomics of oxidative stress response in enteric parasites.
  • Molecular epidemiology of enteric parasites

Projects

Intramural

  • Studies on the Redox Homeostasis and antioxidant signalling in Giardia lamblia

Extramural

  • Studies on burden of parasitic infections among different communities in Western part of India to support health impact evaluation of Total Sanitation campaign. Funded by: GFK Mode Ltd. India.
  • Differential pathogenesis of Giardia : Role of Giardia Virus. Funded by: National Institute of Infectious Diseases, Japan.
  • Oxydative stress regulation in microaerophilic Giardia lamblia. Funded by: Okayama University, Japan
  • Surveillance of Diarrhoeal Disease in the ID Hospital Kolkata.(Co PI). Funded by: Okayama University, Japan

Previously Finished Projects

  • Study the prevalence and genetic characterization of Entamoebahistolytica reference strains from Kolkata, India. Funded by: Japan Health Sciences Foundation, Japan.
  • To study the presence of common enteric parasites found during regular hand washing. Funded by: Research Foundation of City University of New York, USA.
  • Studies on helminthic infections in children among different communities in West Bengal. Funded by: Childrens International, Kansas City, USA.
  • Studies on rRNA processing in Giardia Lamblia. Funded by: Department of Science and Technology, India.
  • Studies on Differential Expression of High Oxygen Induced Proteins in Giardia lamblia. Funded by: Okayama University, Japan.
  • Incidence of Cryptosporidium in Children among different hospitals in Kolkata. Funded by: Emerging and Reemerging Infectious Diseases and Disease Surveillance - CDC, USA.
  • Role of phosphoinositides in intracellular trafficking of Giardia lamblia (Co PI). Funded by: Council of Scientific and Industrial Research, India.

Pre-doctoral and Post-doctoral students

Post-Doctoral Fellow:

  • Dr. Prasanta Saini

PhD students:

  • Mr. Dibyendu Raj
  • Mr. SumallyaKarmakar
  • Mr. SoumyadipPanja
  • Ms. Rituparna Sarkar

Previous PhD students:

  • Dr. Arjun Ghosh (2007-2011)
  • Dr. Esha Ghosh (2007-2011)
  • Mr. Avik K. Mukherjee (2008-2013)
  • Mr. Koushik Das (2009-2014)

Awards

  • Awarded Merit Scholarship in All India Science Aptitude and Talent Search Test in 1984
  • Awarded Merit Scholarship in All India Science Aptitude and Talent Search Test in 1988.
  • Awarded the Best Presentation Award in 15th National Congress of Parasitology, October 2001, Jodhpur, India.
  • Awarded Best Presentation Award in Frontiers in Molecular Biology organized by Department of Biophysics and Molecular Biology, University of Calcutta. 2003.
  • Awarded Young Scientist Award by International Union of Biochemistry and Molecular Biology, Montreal, Canada in 2003.
  • Awarded DST Fast Track Young Scientist Award 2005-2006.
  • All India Radio interviews as a resource person on different infectious diseases from 2007 till date.
  • Resource person & technical expert in Laser Scanning Confocal Microscopy, FLIM, FCS etc. at different Govt. Research Organizations across India.
  • Sir Sriram award from National Academy of Medical Sciences for the year 2007-2008.
  • Top Reviewer Honor (2009-10) from Parasitology International journal published by Elsevier.
  • Reviewer of different peer reviewed International Journals viz. Parasitology International, Epidemiology and Infection, Chemotherapy, Indian Journal of Gastroenterology etc.
  • Advisory committee member of Department of Microbiology at Saint Xaviers College, Kolkata (Autonomous).

Memberships

  • Indian Society for Parasitology
  • The Indian Science Congress Association.
  • Society for Biological Chemists, India.
  • Indian Science Congress Association.

Publications

2016

  1. Das K., P. Chowdhury, T. Nozaki and S. Ganguly. 2016. Genetic characterization of Entamoeba histolytica reveals a significant association of parasite genotype with disease outcome. J Adv Biotechnol. 6:798-806

2015

  1. Sinha A, A. Ray, S. Ganguly, S. Ghosh Dastidar and S. Sarkar. 2015. Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia. Biol Direct10:56. Pubmed
  2. Das K, P. Chowdhury, S. Ganguly. 2015. Internal Transcribed Spacer 1 (ITS1) based sequence typing reveals phylogenetically distinct Ascaris population. ComputStructBiotechnol J. 13:478-483 Pubmed
  3. Raj D, P. Saini, T. Nozaki, S. Ganguly. 2015. Involvement of pyruvate on oxidative stress management in the microaerophilic protozoan parasite Giardia lamblia. Int J Adv Res 3(4): 1148-1166

2014

  1. Das K, S Ganguly. 2014. Evolutionary genomics and population structure of Entamoebahistolytica. Comp Struc Biotech J 12: 26-33. Pubmed
  2. Patil SR, FB Arnold, AL Salvatore, B Briceno, S Ganguly, JM Colford Jr, PJ Gertler. 2014. The Effect of India's Total Sanitation Campaign on Defecation Behaviors and Child Health in Rural Madhya Pradesh: A Cluster Randomized Controlled Trial. PLoS Med. 26;11(8):e1001709 Pubmed
  3. Mukherjee AK, P Chowdhury, K Rajendran, T Nozaki, and S Ganguly. 2014. Association between Giardia duodenalis and Coinfection with Other Diarrhea-Causing Pathogens in India. Biomed Res Int. 2014;2014:786480. Pubmed
  4. Panda S, AK Deb, MC Sarkar, T Ramamurthy, S Ganguly, P Pradhan, A Chakraborty, S Desai, MD Gupte and R. Dhere. 2014. Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India. EpidemInfec. 142(9):1848-58 Pubmed
  5. Das K, AK Mukherjee, P Chowdhury, R Sehgal, MK Bhattacharya, T Hashimoto, T Nozaki and S Ganguly. 2014. Multilocus sequence typing system (MLST) reveals a significant association of Entamoebahistolytica genetic patterns with disease outcome. Parasitology International 63: 308-314 Pubmed
  6. Raj D, E Ghosh, T Nozaki and S Ganguly. 2014. Differential Gene Expression in Giardia lamblia under Oxidative Stress: Significance in Drug Designing and Eukaryotic Evolution. Gene 535: 131-139. Pubmed

2013

  1. Karmakar S, AK Mukherjee, and S Ganguly. Electroporation of snoRNA in Giardia lamblia. 2013. Global J Bio Agri Health Sci. 2(4):20-21
  2. Ghosh A, S Karmakar, AK Mukherjee, D Raj, K Das, S Sarkar, T Nozaki, and S Ganguly. 2013. The splicosomal protein SnRNP F binds to both U3 and U14 class of snoRNA in Giardia lamblia. Global J Bio Agri Health Sci. 2(3):178-184.
  3. Mukherjee AK, P Chowdhury, K Das, D Raj, S Karmakar and S Ganguly. 2013. Helminth burden among school going children of southern Bengal, India: A survey report. Global J Bio Agri Health Sci. 2(3):189-191
  4. Karmakar S, D Raj and S Ganguly. 2013. Identification of the N-terminal Glycinearginine Rich (GAR) Domain in Giardia lambliaFibrillarin and Evidence of its Essentiality for snoRNA Binding. Int.J. Trop. Dis. Health 3(4): 318-327.
  5. Mukherjee AK, S Karmakar, D Raj and S Ganguly. 2013. Multi-locus Genotyping Reveals High Occurrence of Mixed Assemblages in Giardia duodenalis within a Limited Geographical Boundary. British Microbiology Research Journal, 3(2): 190-197
  6. Khalid IM, KA Talukder, M Aslam, R Haque, S Ganguly, IJ Azmi, MS Hossain, AK Mukherjee, D Raj, I Ahmed, J Kamal, JR Rubino, AN Kamal. 2013. Natural contamination of human hands with enteric parasites in Indian Subcontinent. World J Clin Infect Dis. 3(2): 13-19
  7. Li W, V Cama, FO Akinbo, S Ganguly, NM Kiulia, X Zhang, L Xiao. 2013. Multilocus sequence typing of Enterocytozoonbieneusi: Lack of geographic segregation and existence of genetically isolated sub-populations. Infect Genet Evol. 19;14C:111-119. Pubmed

2012

  1. Pativada M, SM Nataraju, B Ganesh, K Rajendran, T Ramamurthy, S Ganguly, MK Bhattacharya, M Ghosh, N Kobayashi, T Krishnan. 2012. Emerging trends in the epidemiology of human astrovirus infection among infants, children and adults hospitalized with acute watery diarrhea in Kolkata, India. Infection Genetics and Evolution12: 1685-1693 Pubmed

2011

  1. Khan SM, C Debnath, AK Pramanik, L Xiao, T Nozaki and S Ganguly. 2011. Molecular evidence for zoonotic transmission of Giardia duodenalis among dairy farm workers in West Bengal, India. Vet Parasitol. 178: 342-345
  2. Sinha A, S Mandal, S Banerjee, A Ghosh, S Ganguly, A K Sil and S Sarkar. 2011. Identification and Characterization of a FYVE Domain from the Early Diverging Eukaryote Giardia lamblia. Curr Microbiol 62:1179-1184
  3. Nataraju, S. M., M Pativada, D Chatterjee, MK Nayak, B Ganesh, MK Bhattacharya, T Ramamurthy, S Ganguly, DR Saha, K Rajendran, M Ghosh, N Kobayashi, T Krishnan. 2011. Molecular epidemiology of norovirus infections in children and adults: sequence analysis of region C indicates genetic diversity of NVGII strains in Kolkata, India. Epidemiol Infect. 19: 1-9. Pubmed

2010

  1. Mukherjee, A. K., K. Das, M. K. Bhattacharya, T. Nozaki, S. Ganguly. 2010. Trend of Entamoeba histolytica infestation in Kolkata. Gut Pathogens. 2: 12. Pubmed
  2. Nair G. B., T Ramamurthy., M. K Bhattacharya., T Krishnan., S Ganguly., K Rajendran., B Manna., M Ghosh., K Okamoto. and Y. Takeda. 2010. Emerging trends in etiology of diarrheal pathogens in hospitalized cases at the Infectious Diseases Hospital, Kolkata, India. GUT Pathogens. 2:4 Pubmed
  3. Nataraju, S. M., M Pativada, D Chatterjee, MK Nayak, B Ganesh, MK Bhattacharya, T Ramamurthy, S Ganguly, DR Saha, K Rajendran, M Ghosh, N Kobayashi, T Krishnan. 2010. Molecular epidemiology of norovirus infections in children and adults: sequence analysis of region C indicates genetic diversity of NVGII strains in Kolkata, India. Epidemiol Infect. 19: 1-9. Pubmed
  4. Khan, S. M., C Debnath, AK Pramanik, L Xiao, T Nozaki, S Ganguly. 2010. Molecular characterization and assessment of zoonotic transmission of Cryptosporidium from dairy cattle in West Bengal, India. Vet Parasitol. 171: 41-47. Pubmed
  5. Sarkar, S., R Banerjee, S Chanda, P Das, S Ganguly and S Pal. 2010. Effectiveness of inoculation with isolated Geobacillus strains in the thermophilic stage of vegetable waste composting. Bioresource Technology 101: 2892-2895. Pubmed
  6. Khan SM, C Debnath, AK Pramanik, L Xiao, T Nozaki and S Ganguly. 2010. Molecular characterization and assessment of zoonotic transmission of Cryptosporidium from dairy cattle in West Bengal, India. Vet Parasitol. 171: 41-47.
  7. Nair G. B., T Ramamurthy., M. K Bhattacharya., T Krishnan., S Ganguly., K Rajendran., B Manna., M Ghosh., K Okamoto. and Y. Takeda. 2010. Emerging trends in etiology of diarrheal pathogens in hospitalized cases at the Infectious Diseases Hospital, Kolkata, India. GUT Pathog. 2:4
  8. Sarkar S, R Banerjee, S Chanda, P Das, S Ganguly and S. Pal. 2010. Effectiveness of inoculation with isolated Geobacillus strains in the thermophilic stage of vegetable waste composting. Bioresour Technol 101: 2892-2895.

2009

  1. Mukherjee A. K., M. K Bhattacharya.,. M Ghosh., K Rajendran.., and S. Ganguly. 2009. Hospital based surveillance study on the prevalence of Giardia lamblia, Cryptosporidium sp. and Entamoeba histolytica in Kolkata. BMC Research Notes, 2: 110.
  2. Ghosal A., R Bhowmik., R Banerjee., S Ganguly., S Yamasaki., T Ramamurthy., T Hamabata and N. S. Chatterjee. 2009. Characterization and the studies of cellular interaction of native colonization factor CS6 purified from a clinical isolate of enterotoxigenic Escherichia coli. Infect Immun 77: 2125- 2135.
  3. Ghosh, E., A. Ghosh, A. N. Ghosh, T. Nozaki and S. Ganguly. 2009. Oxidative stress induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia. Drug Design, Development and Therapy. 3: 1-8.

2008

  1. Ghosh, A., E. Ghosh and S. Ganguly. 2008 Fibrillarin and rRNA processing in enteric parasite Giardia lamblia. Ind J. of Trop Para. 2: 66-74.
  2. Bhowmick, R., A. Ghosal, B. Das, H. Koley, D. R. Saha, S. Ganguly, R. K. Nandy, R. K. Bhadra, N. S. Chatterjee. 2008. Intestinal adherence of Vibrio cholerae involves a coordinated interaction between colonization GbpA and mucin. Infection & Immunity. 76: 4968-77. Pubmed

2007

  1. Dey, R., N. Majumder, S. Bhattacharjee, S. B. Majumdar, R. Banerjee, S. Ganguly, P. Das and S. Majumdar. 2007. Leishmania donovani Induced Ceramide As The Key Mediator of Akt Dephosphorylation In Murine Macrophages: Role of PKC (zeta) And Phosphatase. Infect. Immun. 75: 2136-2142. Pubmed

2006

  1. Das, P., S. Saha Roy, K. Mitra Dhar, P. Dutta, M. K. Bhattacharya, A. Sen, S. Ganguly, S. K. Bhattacharya, A. A. Lal and X. Lihua. 2006. Molecular Characterization of Cryptosporidium spp. in children in Kolkata, India. J. Clin. Microbiol. 44: 4246-4249. Pubmed

2004

  1. Ganguly, S., S. Ghosh, D. Chattopadhyay and P. Das. 2004. Antisense molecular beacon strategy for in situ visualization of snRNA and fibrillarin protein interaction in Giardia lamblia. RNA Biology. 1: 48-53. Pubmed

2003

  1. Ganguly, S., S. Ghosh, D. Chattopadhyay and P. Das. 2003. Localization of fibrillarin and its role in formation of ribonucleoprotein particles with small nuclear RNAs for post-transcriptional modification of rRNA in Giardia lamblia. Mol. Cell. proteomics. 2: 633.
  2. Dasgupta, B., K. Roychoudhury, S. Ganguly, P. K. Sinha, S. Vimal, P. Das and S. Roy. 2003. Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. Annals of Trop. Med. Parasitol. 97: 245-257. Pubmed
  3. Sen, P., S. Mukherjee, G. Bhaumik, P. Das, S. Ganguly, N. Choudhury and S. Raha. 2003. Enhancement of catalase activity by repeatitive low grade H2O2 exposure protects fibroblasts from subsequent stress-induced apoptosis. Mut. Res. 529: 87-94. Pubmed
  4. Dasgupta, B., K. Roychoudhury, S. Ganguly, A. Akbar, P. Das and S. Roy. 2003. Infection of human mononuclear phagocytes and macrophage-like thp1 cells with Leishmania donovani results in modulation of expression of a subset of chemokines and a chemokine receptor. Scand. J. Immunol. 57: 366-374. Pubmed

2002

  1. Sengupta, K., PK Ghosh, S Ganguly, P Das, TK Mitra and KN Jalan. 2002. Identification of Entamoeba histolytica antigens in circulating immune complexes in amoebiasis patients. Journal of Health, Population and Nutrition. 20: 215-222. Pubmed

2000

  1. Sengupta, S., A Akbar, P Mukhopadhyay, S Ganguly, P Sen and P Das. 2000. Role of Excretory-Secretory Products of E. histolytica in Human Amoebiasis. Archives of medical research. 31-4: S226-S228. Pubmed
  2. Mukhopadhyay, P., S Sengupta, A Akbar, K Sengupta, S Bhattacharya, A Debnath, S Ganguly and P Das. 2000. Characterization of Plasma Membrane Associated Antigens of Diagnostic and Prophylactic Importance in Entamoeba histolytica. Archives of medical research 31-4: S21-S22. Pubmed

Book Chapters

  1. Giardia and Giardiasis: An Overview On Recent Developments. Book chapter published in The Handbook of Microbial Bioresources, edited by V K Gupta, G D Sharma, M G Tuohy, R Gaur. Page 211-227, June 2016. Published by CABI, Boston, USA
  2. Ganguly S. Amoebiasis. 2015. Book chapter in Biology of foodborne parasites. Edited by Lihua Xiao, Una Ryan and Yaoyu Feng. Taylor & Francis, USA. 2015
  3. Bhattacharya SK and S Ganguly. Cholera. 2015. Book Chapter in API Textbook of Medicine. Edited by Y P Munjal.
  4. Sandipan Ganguly. Amoebiasis. 2015. Book chapter in Biology of foodborne parasites. Edited by Lihua Xiao, Una Ryan and Yaoyu Feng. Taylor Francis, USA.
  5. Sujit K Bhattacharya and Sandipan Ganguly. Cholera. 2014. Book Chapter in API Textbook of Medicine. Edite by Y P Munjal.
  6. Sandipan Ganguly and Sumallya Karmakar. Electroporation of snoRNA in Giardia lmblia. Microscopy: advances in scientific research and education (A. Mêndez - Vilas, Ed.). Formatex, Spain, 2014
  7. Mukherjee AK, P Chowdhury, MK Bhattacharya, T van Gool, T Nozaki and S Ganguly. 2011. TFT a novel stool collection procedure for enhanced microscopical detection of enteric parasites: First trial among parasite burden population in Kolkata. Book Chapter in Microscopy - Science Technology Applications and Education (MICROSCOPY BOOK SERIES - Number 4), Chapter 295. Published by Formatex, Spain. Editor: A. Mêndez-Vilas, J. Dìaz
  8. Sandipan Ganguly. 2007. Fluorescence Resonance Energy Transfer using molecular beacon as a probe, a new approach for in vivo macromolecular interaction study. Modern Research and Educational Topics in Microscopy, published by Formatex, Spain.

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