I, Dr. Nabendu Sekhar Chatterjee, Scientist D, was born on 2 September 1965 and joined National Institute of Cholera and Enteric Diseases, ICMR, on 17 August 2001. I did B.Sc in Chemistry from Presidency College (Calcutta University) in 1988; M.Sc. in Biochemistry from Calcutta University in 1990; and Ph.D. in Chemistry from the University of Nebraska-Lincoln, USA in 1997. Specialization is molecular biology with special emphasis on molecular characterization of translation-related gene products and studying transcriptional regulation of the related genes. Visiting postdoctoral researcher in the University of California-Davis, USA (1997-1998); Post graduate researcher in the University of California-Irvine, USA during 1998-2001 with experience the molecular regulation of water-soluble vitamin transporters.
My lab is currently interested in different aspects of interaction between host and pathogen. The host-pathogen interaction research involves understanding molecular biology of bacterial pathogens and the mechanisms by which they interact with hosts. Two bacterial pathogens under investigation are Vibrio cholerae, and enterotoxigenic Escherichia coli, which are the prevalent bacterial pathogens for watery diarrhea in developing countries. We have undertaken different projects to characterize different adhesins/colonization factors and study the regulation of their gene expression. We also try to identify and characterize the host receptors involved in bacterial colonization, study host host receptor and pathogen's colonization factors' interaction and understand the molecular mechanisms of colonization. We further aim to look into host response triggered by the colonization factors from V. cholerae and ETEC and induction of host signal transduction pathways by these pathogens during colonization. I am member of the following societies.
|Name||Dr. Nabendu Sekhar Chatterjee|
|Date of joining ICMR||17th August 2001|
|Date of joining present post||September 01, 2015|
|Specialization||Biochemistry and Molecular Biology|
|Email :||email@example.com , firstname.lastname@example.org|
|Graduation||Graduation: B.Sc (Chemistry Hons.)|
|Post Graduation||M.Sc (Biochemistry)|
I received Ph.D. in 1997 from the University of Nebraska-Lincoln, USA in 1997. My specialization was molecular biology with special emphasis on molecular characterization of translation-related gene products and studying transcriptional regulation of the related genes. I gained experience in biochemical characterization of proteins a visiting postdoctoral researcher in the University of California-Davis, USA (1997-1998). As a post graduate researcher in the University of California-Irvine, USA (1998-2001), my experiencewas on understanding molecular regulation of water-soluble vitamin transporters. I joined ICMR-NICED in August 2001 as Scientist C, where I started research on enteric diseases. Since then my research is focused on host-pathogen interaction. I was promoted to Scientist D in 2006, Scientist E in 2010 and Scientist F in 2015. My experience is to characterize the microbial proteins in relation to structure and pathogenesis of enteric diseases and host response and study the regulation of their gene expression.
My lab is primarily focuses on in-depth understanding of the molecular mechanisms of host pathogen interaction using biochemical and biophysical approaches. The molecules of interest are Vibrio choleraechitinases, chitin-binding proteins, their regulators and colonization factors of enterotoxigenicEscherichia coli (ETEC). Knowledge generated has already begun to provide a greater understanding of the complexity of bacterial pathogenesis and aim to translate the knowledge in developing therapeutic intervention strategies against enteric infections in near future. Further, know-how gathered is being applied to establish molecular tools for detection of virulence markers in pathogenic strains.