ICMR - NICED


ICMR-National Institute of Cholera and Enteric Diseases

आई सी एम आर - राष्ट्रीय कॉलरा और आंत्र रोग संस्थान

Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
WHO Collaborating Centre For Research and Training On Diarrhoeal Diseases

NICED : Scientists

Dr. Moumita Dutta

Dr. Moumita Dutta

 

General Information
Name Dr. Moumita Dutta
Designation Scientist C
Date of joining ICMR 01 December 2017
Date of joining present post 01 December 2017
Discipline Electron Microscopy
Division  
Specialization  
Email : mdutta16@gmail.com  ; moumita.dutta@icmr.gov.in
Academic Qualification  
Graduation Chemistry(H) (University of Calcutta)
Post Graduation Biochemistry (University of Calcutta)
Doctoral NICED/Jadavpur University (Characterization of Choleraphages using Electron Microscopy). .

Profile

Research Experience

I have several years of research experience on various electron microscopic techniques: negative staining, cryo-electron microscopy, single particle analysis, cryo-electron tomography, immune-electron microscopy, ultramicrotomy, Kleinschmidt's protein monolayer technique, and partial denaturation mapping of DNA. I have worked as a postdoctoral research associate at Florida State University (USA) on HIV/SIV glycoprotein spikes and their complexes with broadly neutralizing antibodies using cryo-electron tomography and subtomogram averaging to provide structural information for designing better immunogen. I have also worked on structural intermediates of the bacterial replication initiation process and retroviral capsid structures using cryo-electron tomography as a career development fellow at Francis Crick Institute, London. Later I worked as a senior staff scientist in cryo-electron microscopy at the University of Sheffield, UK. Since my joining at NICED, my laboratory is working on enteric bacteriophages and their characterization by biophysical and structural methods...
 

Research Interest

My research interest focuses on studying enteric bacteriophages and their three-dimensional structure determination. Another research area is the enveloped viruses and associated membrane proteins to understand the structure-function relation and fundamental processes such as host-virus interaction and viral entry. I am also interested in structural analysis of protein and their complexes, immune-complexes to explain their functions in biological processes and related diseases. Surface structural changes and in-depth ultrastructural changes caused by different enteric pathogens are also studied in our division by scanning and transmission electron microscopy techniques. Bacteriophage-host bacteria interactions are studies at high-resolution using a cutting-edge technique cryo-electron microscopy and tomography along with image processing techniques.

Membership/ Fellow of Professional Societies/ Associations

National

  1. Life Member: Society for Bacteriophage Research and Therapy
  2. Life member: Electron Microscope Society of India

International

  1. Member: Royal Microscopical Society
  2. Member: European Microscopy Society

Projects

Intramural

  1. High-Resolution Structural Studies of Newly Isolated Shigella Phages by Cryo-electron Microscopy and Image Processing. 2018-2021

Students (Please include names of students presently working in the lab)

JRF : Payel Mondal (CSIR)
SRF : Bani Mallick (UGC)
 

Publications

2021

  1. Banerjee S, Bhattacharya A, Roychoudhury P, Dasgupta AK, Dutta M and Pal R. Arthrospira platensis(Cyanobacteria)– a potential biofactory for fluoromagnetic nanoiron production. Phycologia 2021.
  2. Maiti S, Howlader DR, Halder P, Bhaumik U, Dutta M, Dutta S, Koley H. Bivalent non-typhoidal Salmonella outer membrane vesicles immunized mice sera confer passive protection against gastroenteritis in a suckling mice model. Vaccine. 2021. Vol 39(2): 380-393. https://doi.org/10.1016/j.vaccine.2020.11.040 . .

2020

  1. Das S, Chourashi R, Mukherjee P, Gope A, Koley H, Dutta M, Mukhopadhyay AK, Okamoto K, Chatterjee NS. Multifunctional transcription factor CytR of Vibrio cholerae is important for pathogenesis. Microbiology (Reading). 2020 Dec;166(12):1136-1148. doi: 10.1099/mic.0.000949. PMID: 33150864.
  2. Ghosh S, Bhowmik S, Majumdar S, Goswami A, Chakraborty J, Gupta S, Aggarwal S, Ray S, Chatterjee R, Bhattacharyya S, Dutta M, Datta S, Chowdhury A, Dhali GK, Banerjee S. The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. Int J Cancer. 2020 Nov;147(10):2934-2947. DOI: 10.1002/ijc.33111.
  3. The Protective Role of Metformin in Autophagic Status in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients. Bhattacharya D, Dutta M, Mukhopadhyay M, Bhattacharyya M, Chowdhury S, Karmakar P. Cell Biol Int. 2020 Aug;44(8):1628-1639. doi: 10.1002/cbin.11355. PMID: 32237184.
  4. Antibacterial, anti-biofilm activity and mechanism of action of Pancreatin doped Zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus. Banerjee S, Vishakha K, Das S, Dutta M, Mukherjee D, Mondal J, Mondal S, Ganguli A. Colloids Surf B Biointerfaces. 2020 Jun; 190:110921. doi: 10.1016/j.colsurfb.2020.110921. PMID: 32172163.
  5. Emergence of OXA-232-producing hypervirulent Klebsiella pneumoniae ST23 causing neonatal sepsis. Mukherjee S, Naha S, Bhadury P, Saha B, Dutta M, Dutta S, Basu S. J Antimicrob Chemother. 2020 Jul 1;75(7):2004-2006. doi: 10.1093/jac/dkaa080. PMID: 32155265.
  6. Segmentation by Classification: A Novel and Reliable Approach for Semi-Automatic Selection of HIV/SIV Envelope Spikes. Banerjee C, Dutta M, Liu X, Roux KH, Taylor KA. J Struct Biol. 2020 Jan 1;209(1):107426. doi: 10.1016/j.jsb.2019.107426.
  7. Iron-Induced Apoptotic Cell Death and Autophagy Dysfunction in Human Neuroblastoma Cell Line SH-SY5Y. Rakshit J, Mallick A, Roy S, Sarbajna A, Dutta M, Bandyopadhyay J. Biol Trace Elem Res. 2020 Jan;193(1):138-151. doi: 10.1007/s12011-019-01679-6. .

2019

  1. Size-dependent antibacterial activity of copper nanoparticles against Xanthomonas oryzae pv. oryzae – A synthetic and mechanistic approach. Majumdar TD, Singh M, Thapa M, Dutta M, Mukherjee A, Ghosh CK. Colloid and Interface Science Communications Sept 2019, Vol 32, 100190.
  2. Structural analysis and proteomics studies on the Myoviridae vibriophage M4. Das S, Dutta M, Sen A, Ghosh AN. Arch Virol. 2019 Feb;164(2):523-534. doi: 10.1007/s00705-018-4100-7. Epub 2018 Nov 27. Erratum in: Arch Virol. 2019 Sep;164(9):2431.

2018

  1. Recent Advances in Single Particle Cryo-electron Microscopy and Cryo-electron Tomography to Determine the Structures of Biological Macromolecules. Moumita Dutta. Journal of the Indian Institute of Science 2018, 98 (3), 231-245.

2016

  1. Arbore, C., Dutta, M., Solscheid, C., Rosenthal, P., Molloy, J., Webb, M. Visualization of structural intermediates of replisome initiation complex formation on plasmid DNA replication (manuscript submitted).
  2. Mukherjee, CB., Dutta, M., Winkler, H., Liu, X., Roux, KH and Taylor, KA. Visualization of SIV envelope spike with automated particle picking on intact viruses by cryo-electron tomography (manuscript submitted).
  3. Ball NJ, Nicastro G, Dutta M, Pollard DJ, Goldstone DC, Sanz-Ramos M, Ramos A, Müllers E, Stirnnagel K, Stanke N, Lindemann D, Stoye JP, Taylor WR, Rosenthal PB, Taylor IA. Structure of a Spuma retrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid. PLoS Pathog. 2016 Nov 9;12(11):e1005981.  Pubmed
  4. Gieras A, Linhart B, Roux KH, Dutta M, Khodoun M, Zafred D, Cabauatan CR, Lupinek C, Weber M, Focke-Tejkl M, Keller W, Finkelman FD, Valenta R. IgE epitope proximity determines immune complex shape and effector cell activation capacity. J Allergy Clin Immunol. 2016 May;137(5):1557-65 Pubmed

2014

  1. Dutta M, Liu J, Roux KH, Taylor KA. Visualization of retroviral envelope spikes in complex with the V3 loop antibody 447-52D on intact viruses by cryo-electron tomography. J Virol. 2014 Nov;88(21):12265-75.  Pubmed

2012

  1. Rathinakumar R, Dutta M, Zhu P, Johnson WE, Roux KH. Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and –unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions. J Virol. 2012 Feb;86(3):1820-31.   Pubmed

2007

  1. Dutta M, Ghosh AN. Physicochemical characterization of El Tor Vibriophage S20. Intervirology. 2007;50(4):264-72. Pubmed

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