|Name||Dr. Moumita Bhaumik (Ghosh)|
|Date of joining ICMR||06 November 2017|
|Date of joining present post||06 November 2017|
|Graduation||Zoology, University of Calcutta|
|Post Graduation||Biophysics and Molecular biology. University of Calcutta|
|Doctoral||Biophysics and Molecular biology, CSIR-IICB, Kolkata|
My doctoral research experience revolved around the
pathogenesis of the Leishmania infection.
Leishmania, a protozoan parasite causing the disease
Kala-azar exhibit a pronounced tropism for macrophages.
Once, the parasite is well established, it causes
aberrant changes in macrophage property and function. My
study was designed to understand the 'complex rules' by
which Leishmania parasites modulate the
biological functions of the macrophage affecting the
antileishmanial immune repertoire. All the studies were
restricted on three aspects of cell biology of
Leishmania infected macrophage - the macrophage
membrane function, effective immune stimulation by
antileishmanial drugs and antigen processing and
presentation of exogenous antigen. Thus, it was shown
how Leishmania parasites modulate the macrophage
function which may have significant impact on the
immunopathology of Leishmaniasis.
I thrust my interest on commensal bacteria which constitutes an ecosystem inside our gut, known as "microbiome". It has a protective, metabolic and trophic functions thus regulating various physiological system of our body. For which, the body requires keyinduction and maintenance signals from microbiome, many of them are yet to be discovered. I would pursue my studies on the following aspects of gut microbiotaand host interactionto find out the key factor. First, the impact of microbiome on immune system of the host. Second, the mechanism by which it orchestrates the physiology of the host. Third, the environmental factorsand antibiotics on perturbing gut microbiome, affecting host physiology.