National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India
WHO Collaborating Centre for Research and Training on Diarrhoeal Diseases

NICED : Scientists

Dr. M. K. Saha

Dr. M. K. Saha

Dr. M K Saha has been working as Scientist at the National Institute of Cholera and Enteric Diseases (NICED) in Kolkata since 1989. Dr. Saha did Graduation (1978), Masters (1980) and Ph D (1988) from Kalyani University. He joined NICED in the Division of Immunology and worked till 1992, after which he has been working in the Division of Virology. Additionally, since 2007, working in the newly created Clinical Laboratory for vaccine and drug trial.

Currently, Dr. Saha is a member of the Sectional Committee of Immuno-Biological Diagnostic Kits, Bureau of Indian Standards. Govt of India. Dr. Saha is In-charge of the National HIV Reference Laboratory at NICED which is a NABL accredited laboratory and this lab was adjudicated as the best National Reference Lab in the country by CDC-WHO-NACO team evaluation in the year 2008..He is also serving as In-Charge of Regional Reference Lab for Molecular Assay, and Coordinator, NACO-Regional Institute (East) for HIV Sentinel Surveillance.

Dr. Saha worked on environmental strains of Vibrio cholerae, hepatitis viruses and HIV. During 2000-01, for 10 months, he worked as JICA Counter-Part Trainee in Molecular Virology in the Division of Virology-2, National Institute of Infectious Diseases, Tokyo, Japan. He is the author of about 20 research papers. He is a life member of Indian Public Health Association.

General Information
Name Dr. M. K. Saha
Educational Qualification M.Sc., Ph.D.
Designation Scientist-F (Deputy Director) In-Charge, National HIV Reference Lab
Division Virology
Specialization HIV/AIDS, Evaluation of Immuno-Diagnostic Assay. Laboratory Quality Control/Quality Assurance. Development of Nano Particle for Oral Vaccine Delivery. Clinical Trial for Drug and Vaccine.
Date of joining ICMR August 1989
Email : sahamk@yahoo.com , sahamk@icmr.org.in

Profile

Professional Experience

Service at NICED (ICMR):

  • Immunology - Technical Officer, (1989-92).
  • Virology - Research Officer, (1992-98), Sr. Research Officer, (1998-2004), Assistant Director (Scientist D) (2004-2010) and Scientist E (Deputy Director) (2010-Contd).

Scientific/Technical Contribution for External Organization:

  • Temporary Advisor, WHO, Measles Aerosol Vaccine Project.
  • Member, Sectional Committee Immuno-Biological Diagnostic Kits, Bureau of Indian Standards. Govt of India.
  • Member, Expert Committee, Strengthening of Quality Control Testing Procedureof Immuno Diagnostic Kit Laboratory (IKDL),National Institute of Biologicals, N- Delhi.
  • National AIDS Control Program, NACO, Govt. of India:
    1. Focal Person, Regional Institute (East), HIV Sentinel Surveillance and Biological Behavioral Surveillance. NICED.
    2. Laboratory In-Charge
      - National HIV Reference Laboratory (NRL-EQAS), NICED.
      - Regional Reference Laboratory (Molecular HIV Lab), NICED.
      - Consortium of NRLs (NRL on Q). NICED.
    3. In-charge, Integrated Counseling and Testing Centre, NICED.
    4. Lab-Coordinator, Kolkata site, Integrated Bio Behavioral Assessment (IBBA) on HIV Intervention Assessment by National Institute of Medical Statistics (ICMR), N-Delhi

Advanced Learning

  • Molecular Virology: Japan International Cooperation Agency (JICA) counterpart program, March 2000 to Jan 2001.National Institute of Infectious Disease, Tokyo, Govt of Japan.
  • Quality Assurance: Quality System Essentials (ISO 15189:2007& 2012), Good Clinical Laboratory Practice (GCLP) (WHO/TDR), Harmonization of National Reference Labs for Kit Evaluation and Batch Testing (National Serology Reference Lab, Australia) and Good Clinical Practice (World Health Organization).

Research Interests

  • HIV/AIDS
  • Evaluation of Immuno-Assay Kits
  • Laboratory Quality Assurance
  • Uncertainty of Measurement for Laboratory Results
  • Development of Nano-particle for Oral Delivery of Vaccine
  • Clinical Trial of Drug and Vaccine

Projects

Intramural

  • Molecular Characterization of HIV for transmitted drug resistance mutations.

Extramural

  • Molecular characterization of HIV for drug resistance mutations among children using dry blood spot samples. (ICMR Translation Research- 2015-18)
  • External Quality Assurance for HIV testing (NACO; 2002-Contd)
  • HIV sentinel surveillance (NACO;2008-Contd)
  • Evaluation of diagnostic kits for HIV, HBV, & HCV (NACO & Consortium; 2008-Contd).
  • Molecular detection of HIV in babies below 18 months (NACO; 2010-Contd).
  • Molecular assay for HIV Viral load (NACO: 2015-Contd

Pre-doctoral Post-doctoral students

  • Subrata Biswas, Sr. Research Officer (NACO)
  • Srijita Nandi, Research Officer (NACO)

Awards

  • GCP & GCLP Recognition of Laboratory by WHO for Clinical Trial.
  • NABL Accreditation of National HIV Reference Labas per ISO-15189:2012 standard
  • CDC & WHO adjudicated the National HIV Reference Laboratory as the highest ranking lab in the country with more than 90% scoring.
  • CDC, Atlanta, USA awarded Certificate of Excellence, consecutively for three years (2012, 13 & 14) for Outstanding Performance of the Molecular HIV Lab (Regional Reference Lab) in Proficiency Testing using Dry Blot Sample (DBS).

Memberships

  • Indian Public Health Association.

Publications

2015

  1. Saha MK, Mahapatra T, Biswas S, Ghosh P, Kire M. 2015 Burden and Correlates of HIV Risk among Men Who Have Sex with Men in Nagaland, India: Analysis of Sentinel Surveillance Data. PLoS ONE 10(2): e0117385. Pubmed
  2. Mahapatra T, Biswas S, Nandi S, Ghosh P, Ghosh M, Mondal S, Saha MK. Burden and Correlates of HIV among Men Who Have Sex with Men in West Bengal, India: Analysis of Sentinel Surveillance Data.PLoS One. 2015 10(5):e0127232. Pubmed
  3. Saha M K, Mahapatra T, Biswas S, Ghosh P, Mahapatra, Deb A. K., Diwan K. Sociobehavioral Correlates of HIV Risk among Men Who Have Sex with Men in Chhattisgarh, India: Analysis of Sentinel Surveillance Data. Jpn. J. Infect. Dis. 2015. 68 (1), 38-44, 2015. Pubmed
  4. Panda S, Bandopadhyaya D, Saha M K, Pahari S, Chakrabarti S, Niyogi S. Correlates of HIV transmission from husband to wife among heterosexual married couples in ATR in West Bengal, India. J AIDS Clin Res. 2015. 6: 417
  5. Biswas S, Chattopadhyay M, Sen K K, Saha M K. Development and characterisation of alginate coated low molecular weight chitosan nanoparticles as new carriers for oral vaccine delivery in mice. Carbohydrate Polymers. 2015. 121, 403-410. Pubmed

2014

  1. Nandi S, Maity S, Bhunia S C, Saha M K. Comparative assessment of commercial ELISA kits for detection of HIV in India. BMC Res Notes. 2014. 7:436. Pubmed
  2. Biswas S, Chattopadhyay M, Sen K K, Saha M K, H S Majhi. Structure-toxicity relationship of chemically modified chitosan as an oral protein drug delivery carrier. J. Pharm. Sci. Pharmacol.2014.1, 1-10.
  3. Chatterjee S. Nandi S, Ghosh M. Saha M K. Diagnosing the Infected Child: The Indian Context. 2014.The Positive Child Has a Right to a Positive Life: Action Report on Pediatric HIV in INDIA. Monograph, Section 3.2. Abbott
  4. Biswas S, Sen K K, Roy D, Saha M K. Chitosan-based particulate system for oral vaccine delivery: A review. Int J Pharm. 2014. 4(1): 226-236.
  5. Bhattacharya M K, Saha M K, Chakraborty P S, Sinha A, Bhattacharya A, Dutta K K. HIV/AIDS related deaths from three district hospitals of West Bengal: An observation. J Acute Dis. 2014. 163-164.
  6. Biswas S, Sen K K, Saha M K, Roy D. Development and characterization of o-methylated free n, n, n-trimethylated chitosan nanoparticles as new carriers for oral vaccine delivery in mice. Int J Pharma Bio Sci. 2014. 4:01-13.1

2012

  1. Maity S, Nandi S, Biswas, S Sadhukhan S, Saha M K. 2012. Performance and diagnostic usefulness of commercially available enzyme linked immunosorbent assay and rapid kits for detection of HIV, HBV and HCV in India. Virol J., 9: 290 Pubmed
  2. Maity S, Nandi S, Biswas, S, Saha M K. 2012. Human Immunodeficiency Virus Seroprevalence among Patients Attending a Sexually Transmitted Disease Clinic in West Bengal, India. Jpn. J. Infect. Dis.,. 65: 424-426 Pubmed

2011

  1. Maity S, Bhunia S C, Biswas S, Saha M K. 2011 Syphilis seroprevalence among patients attending a sexually transmitted disease clinic in West Bengal, India. Jpn J Infect Dis. 64: 505-508 Pubmed
  2. Biswas S, Lala D, Teixeira da Silva J A , Sen K K, Saha M K. 2011 Development and Evaluation of Colonic Drug Delivery of Aceclofenac using Pectin and Guar Gum. Int J Biomed Pharmaceut Sci. 5: 79-84.

2009

  1. Deb A K, M Deb, Saha M K , S Chakraborty, S K Bhattacharya, Detels R 2009 HIV transmission potential among local and migrant factory workers in Kolkata, India. AIDS Behav.13: 928-938. Pubmed

2006

  1. Mullick, R., S. Sengupta, K. Sarkar, M. K. Saha, S. Chakrabarti. Phylogenetic analysis of env, gag and tat genes of HIV type 1 detected among the injecting drug users in West Bengal, India. AIDS Res Hum Retroviruses. 2006.  Dec. 22(12): 1293-9.
  2. Sarkar, K., B. Bal, R. Mukherjee, M. K. Saha, S. Chakraborty, S. K. Niyogi, S. K. Bhattacharya. Young age is a risk factor for HIV among female sex workers-an experience from India. J. Infect. 2006 Oct. 53(4): 255-9. Epub 2005 Dec 27.
  3. Sarkar, K., B. Bal, R. Mukherjee, S. Chakraborty, S. K. Niyogi, M. K. Saha, S. K. Bhattacharya. Epidemic of HIV coupled with hepatitis C virus among injecting drug users of Himalayan West Bengal, Eastern India, Bordering Nepal, Bhutan and Bangladesh. Subst Use Misuse. 2006. 41(3): 341-52.

2005

  1. Gangopadhyay, D. N., M. Chanda, K. Sarkar, S. K. Niyogi, S. Chakraborty, M. K. Saha, B. Manna, S. Jana, P. Ray, S. K. Bhattacharya, R. Detels. Evaluation of sexually transmitted diseases/human immunodeficiency virus intervention programs for sex workers in Calcutta, India. Sex Transm Dis. 2005.  Nov. 32(11): 680-4.
  2. Sarkar, K., B. Bal, R. Mukherjee, S. K. Niyogi, M. K. Saha, S. K. Bhattacharya. Epidemiology of HIV infection among brothel-based sex workers in Kolkata, India. J. Health Popul Nutr. 2005. Sep. 23(3): 231-5.
  3. Sarkar, K., B. Bal, R. Mukherjee, S. K. Niyogi, M. K. Saha, S. K. Bhattacharya. Cross border HIV epidemic among injecting drug users of Himalayan West Bengal. Eur J. Epidemiol. 2005. 20(4): 373-4. No abstract available.
  4. Sarkar, K., B. Bal, R. Mukherjee, S. K. Niyogi, M. K. Saha, S. K. Bhattacharya. Cross border HIV epidemic among injecting drug users of Himalayan West Bengal. Eur J. Epidemiol. 2005. 20(4): 373-4. No abstract available.

2004

  1. Sarkar, K., D. N. Ganguly, B. Bal, M. K. Saha, S. K. Bhattacharya. Hepatitis B infection, Eastern India. Emerg Infect Dis. 2004. Jul. 10(7): 1341-2. No abstract available.

2001

  1. Panda, S., L. Bijaya, Devi N. Sadhana, E. Foley, A. Chatterjee, D. Banerjee, T. N. Naik, M. K. Saha, S. K. Bhattacharya.Interface between drug use and sex work in Manipur. Natl Med J. India. 2001. Jul-Aug.14(4): 209-11.

2000

  1. Saha, M. K., S. Chakrabarti, S. Panda, T. N. Naik, B. Manna, A. Chatterjee, R. Detels, S. K. Bhattacharya. Prevalence of HCV HBV infection amongst HIV seropositive intravenous drug users their non-injecting wives in Manipur, India. Indian J. Med Res. 2000. Feb. 111: 37-9.

1999

  1. Saha, M. K., P. Dutta, S. P. De. Possibility of public health hazards by contamination of toxin producing Vibrio cholerae through fishes reared in sewage fed fishery. Indian J. Public Health. 1999.Apr-Jun. 43(2): 71-2.

1998

  1. Panda, S., A. Chatterjee, S. Bhattacharjee, B. Ray, M. K. Saha, S. K. Bhattacharya. HIV, hepatitis B and sexual practices in the street-recruited injecting drug users of Calcutta: risk perception versus observed risks. Int J. STD AIDS. 1998. Apr. 9(4): 214-8.

1992

  1. Chaudhuri, P. P., K. Sengupta, B. Manna, M. K. Saha, S. C. Pal, P. Das. Detection of specific anti-Giardia antibodies in the serodiagnosis of symptomatic giardiasis. J. Diarrhoeal Dis Res. 1992. Sep. 10(3): 151-5.

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