National Institute of Cholera and Enteric Diseases

Indian Council of Medical Research
Department of Health Research, Ministry of Health and Family Welfare, Government of India

NICED : Scientists

Dr. Asish Kumar Mukhopadhyay

Dr. Asish Kumar Mukhopadhyay

Dr. Asish K. Mukhopadhyay is working as at National Institute of Cholera and enteric Diseases, Kolkata since March 2003. After finishing the Masters from University of Calcutta, he started research under Dr. G. Balakrish Nair at the division of Microbiology on the epidemiology, evolution and virulence of Vibrio cholerae, for his doctoral thesis. His thesis research focused on population and molecular analyses of Vibrio cholerae, to gain insights into the interplay between environmental and human disease reservoirs, and genetic factors that make certain lineages of this organism highly virulent to humans. This thesis research contributed to around 25 publications in peer-reviewed journals.

After completion the Ph.D., Dr. Mukhopadhyay moved to research with Dr. Douglas E. Berg, Professor of Molecular Microbiology and of Genetics, Washington University School of Medicine at Saint Louis, USA and worked for five years as research associate. He was particularly interested on the genetic diversity, population genetics and genome evolution of Helicobacter pylori and also contributed importantly to our elucidation of mechanisms of susceptibility and resistance to metronidazole, a critical component of combination therapies that are used against Helicobacter pylori. His detailed analysis of virulence-associated genes and house-keeping genes that are under selective pressures showed that Indian H. pylori gene pool is distinct from the Hp gene pools of other parts of the world. His additional studies had contributed importantly to our understanding of the global population dynamics of transposable elements of H. pylori and how they may affect the vigor or virulence of pathogens and Hp genome evolution as well. In addition to the contributions to the Hp field, he performed detailed fundamentally important analysis of CTX prophages and pathogenicity islands in a subset of environmental strains of Vibrio cholerae.

Dr. Mukhopadhyay also received training under the Japan International Cooperation Agency (JICA) project for 6 months in 2006 at the Department of Bacteriology, Nagasaki University, Japan with Prof. T. Hirayama on different aspects of vacuolating cytotoxin (VacA) of H. pylori. Under his supervision, four research students are working at present and one has already obtained the doctoral degree and he is the author of 72 research papers on several aspects of V. cholerae and H. pylori.

Current research interests of Dr. Mukhopadhyay include diversity, evolution and biology of H. pylori and V. cholerae in the context of molecular pathogenesis, strain evolution and prevention measures. Recently, he has been very successful in adapting Indian H. pylori strains to the murine infection model which will provide further insight into the biological activities of H. pylori virulence proteins and their contributions to bacterial fitness and this holds great promise for functional genomic anlyses of infection and disease processes. Another important pathogen of recent interest is Campylobacter, a significant cause of gastric illness world wide, where the research theme is molecular epidemiology including genomic analysis to provide protected public health.

General Information
Name Dr. Asish Kumar Mukhopadhyay
Designation Scientist E
Date of joining ICMR 4th March 2003
4. Date of joining present post September 1, 2013
Discipline Bacteriology
Division Bacteriology
Specialization Microbiologist
Email mukhopadhyayak.niced@gov.in ; asish_mukhopadhyay@yahoo.com
Academic Qualification  
Post Graduation M.Sc.
Doctoral Ph.D.

Profile

Research Experience

After finishing Masters from University of Calcutta, Dr. Mukhopadhyaystarted research for his doctoral thesis on molecular epidemiology, evolution and virulence of Vibrio cholerae under Dr. GB Nair at NICED. After completing the Ph.D., he moved to research with Dr. Douglas E. Berg, Professor of Molecular Microbiology and of Genetics, Washington University School of Medicine at Saint Louis, USA and worked for five years as research associate on different aspects of Helicobacter pylori. He also worked for 6 months at the Department of Bacteriology, Nagasaki University, Japan with Prof. T. Hirayama on vacuolatingcytotoxin (VacA) of H. pylori during 2006. His analysis on different variant CTX prophages of V. cholerae O139 helped to predict the probable cause of their extinction. His research helped to unravel the genetic makeup of Vibrio cholerae, including hybrid and Haitian strains, which have been implicated in recent outbreaks of devastating proportions around the world. His pioneering research on Helicobacter pylori, causative agent for chronic gastritis and peptic ulcer, first time showed that Indian strains are genetically distinct, which is immensely important from the vaccine development point. His genomic studies helped to understand why metronidazole should be avoided for the treatment of H. pylori in the Indian subcontinent and other studies on curcumin and Elagic acid showed immense therapeutic potential against H. pylori infection, as they were highly effective in eradication of H. pylori from infected mice as well as in restoration of H. pylori-induced gastric damage.

Research Interests

Dr. Mukhopadhyay’s laboratory has been exploring innovative ways of understanding the epidemiology of infectious diseases. As a member of an institution with an interdisciplinary research mandate, he has been able to push the borders of his comfort zone and collaborate with clinicians, epidemiologists and other public health researchers to develop a truly multidisciplinary working environment.

Current research interests of Dr. Mukhopadhyay include diversity, evolution and biology of H. pylori and V. cholerae in the context of molecular pathogenesis, strain evolution and prevention measures. He has been very successful in adapting Indian H. pylori strains to the murine infection model which will provide further insight into the biological activities of H. pylori virulence proteins and their contributions to bacterial fitness and this holds great promise for functional genomic anlyses of infection and disease processes. Another important pathogen of recent interest is Campylobacter, a significant cause of gastric illness worldwide, where the research theme is molecular epidemiology including genomic analysis to provide protected public health.

Membership of Association:

  1. The Indian Science Congress Association Since 2004
  2. Society for the Biological Chemistry Since 2012

Fellow of Professional Societies

Fellow of the West Bengal Academy of Science and Technology(WAST) 2015
 

Awards:

Fellowship awarded:

a) Junior Research Fellowship from Department of Biotechnology, New Delhi (1993-95)
b) Senior Research Fellowship from Indian Council of Medical Research (1995-1997)
c) Young Scientist Scholarship for International Congress for Tropical Medicine and Malaria at Nagasaki, Japan (1996).
 

Patent:

Cholera organisms, vaccines and preparation thereof: Inventors: Thungapathra, M., C. Sharma, N. Gupta, R.K. Ghosh, A.K. Mukhopadhyay, H. Koley, G.B. Nair and A. Ghosh. Patent No.97309957.5-2105, Issued May 1998 by European Patent Office.
 

Projects

Extramural

Ongoing

  • Retrospective analysis on the evolutionary aspects of Vibrio cholerae (NIID, Japan during 2013-2018)
  • Changing pattern of the Vibrio cholerae strains in India along with the antimicrobial resistance and its relationship with pathogenesis for better management of cholera (AMED, Japan through Okayama University during 2015-2020).
  • Role of Helicobacter Pylori Tumour Necrosis Factor Alpha inducing protein (Tip Alpha) in causing gastro duodenal diseases including gastric cancer (Funded by ICMR, Govt. of India; during 2017-2020).
  • Exploratory study to standardize PCR tests on paraffin sections to detect Helicobacter pylori and compare with other detection tests. (Funded by ICMR, Govt. of India; during 2017-2020).

Completed

  • Studies on blood group antigen binding adhesin (babA) gene in relation to Helicobacter pylori mediated diseases outcome in India (Funded by CSIR, Govt. of India; during 2015-2017)
  • Elucidation and analysis of Biological Function(s) of Helicobacter pylori Restriction-Modification systems. (Funded by Department of Biotechnology, Govt. of India during 2009 to 2012).
  • Evolution of CTX prophages of V. cholerae O1 and O139 strains in Kolkata over a decade (Okayama University, Japan during 2010-2014)
     

Students

Past students:

  • Dr. Rajashree Patra (Awarded in 2008)
    Dr. Amit Raychoudhuri (Awarded in 2010)
    Dr. Ronita De (Awardedin 2011)
    Dr. Javed Alam (Awarded in 2014)
    Dr. Priyanka Ghosh (Awarded in 2015)
    Dr. Prachetash Ghosh (Awarded in 2016)

Past students:

  • Mr. Arindam Naha (Pre-doctoral)
  • Ms. Piyali Mukherjee (Pre-doctoral)
  • Mr. BipulKarmakar(Pre-doctoral)
  • Mr. ProsenjitSamanta(Pre-doctoral)
  • Mr. Rudra Narayan Saha(Pre-doctoral)
  • Ms. Sangita Paul (Pre-doctoral)

Post-doc Fellow:

  • Dr. Raghwan Kumar (Post-doctoral)
  • Dr. Goutam Chowdhury (Post-doctoral)
     

Travel to foreign countries to attend conference/ meetings (for the last 5 years):

  1. Dr. Mukhopadhyay was invited by the Center for Global Safe WASH at the Emory University to attend an International Advisory Board Meeting for the SaniPath-Typhoid study between February 28 and March 2, 2018 at Emory University in Atlanta, Georgia, USA.
  2. Dr. Mukhopadhyay was invited at the 52nd US-Japan Joint Panel Conference on Cholera and Other Bacterial Enteric Infections and also to deliver a talk on “Reconnaissance of Indian El Tor vibrios reveal incessant genomic changes" based on his research work during February 20-24, 2018 in Hat Yai, Thailand.
  3. Dr. Mukhopadhyay was invited by US - Japan Cooperative Medical Sciences Program on Cholera and the International Vaccine Institute to attend the US -Japan Cooperative Medical Sciences Program’s 19th International Conference on the Emerging Infectious Disease in the Pacific Rim and to deliver a talk on “Pathogenic modulation in El Tor vibrios: evidence from recent Indian strains harbouring Haitian traits” during February 07-10, 2017 in Seoul, South Korea.
  4. Dr. Mukhopadhyay was invited to attend the NICED-NIID joint bilateral meeting regarding the HMSC cleared collaborative project on “Laboratory based collaboration network of infectious diseases in Asia” and to the International Seminar on Infectious Diseases at the National Institute of Infectious Diseases (NIID), Tokyo, Japan during January 25th-27th 2016. Dr. Mukhopadhyay presented the progress of hisproject on“Retrospective analysis on the evolutionary aspects of Vibrio cholerae”.
  5. Dr. Mukhopadhyay was invited byNational Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) to attend the United States-Japan (US-Japan) Cooperative Medical Sciences Program (CMSP) 50th anniversary celebration followed by the 18th International Conference on “Emerging Infectious Diseases (EID) in the Pacific Rim” and also to present his research work at the “Cholera Panel Meeting” under US-Japan CMSP; during January 11-15, 2016 at Bethesda, Maryland, USA.
  6. Oral Presentation on “Major Genetic events in the evolution of Vibrio cholerae O1 for the last two decades at Kolkata, India” in the “The International Union of Microbiological Societies (IUMS 2014) - XIVth International Congress of Bacteriology and Applied Microbiology, XIVth International Congress of Mycology and Eukaryotic Microbiology, XVIth International Congress of Virology held in Montreal, Canada during July 27 - August 1, 2014.
  7. Presentation of the work entitled “Sequential Genetic Variations of the Vibrio cholerae strains from Kolkata, India and its relation with the Haitian strains” in the “Annual Asia-African Research Forum” organized by the Japan Initiative for Global Research Network on Infectious Diseasesheld in Sendai, Japan during January 20-22, 2014.
  8. Attended the NICED-NIID joint bilateral meeting regarding the HMSC cleared collaborative project on “Laboratory based collaboration network of infectious diseases in Asia” and presented the progress of his work in the meeting held in NIID, Tokyo, Japan during September 25-27, 2013.
  9. Presentation of the work entitled “Characteristics of Indian Vibrio cholerae strains: Traces of Haitian Variant” in the 5th Congress of European Microbiologists (FEMS) held in Leipzig, Germany during July 21-25, 2013.
  10. Presentation of the work entitled “Genetic Attributes of Indian Vibrio cholerae strains: Evidence for the genesisof Haitian variant”.in the “Annual Asia-African Research Forum” organized by the Japan Initiative for Global Research Network on Infectious Diseases held in Tokyo, Japan during January 23-24, 2013.
     

Publications

2017

  1. Weill FX, Domman D, Njamkepo E, Tarr C, Rauzier J, Fawal N, Keddy KH, Salje H, Moore S, Mukhopadhyay AK, Bercion R, Luquero FJ, Ngandjio A, Dosso M, Monakhova E, Garin B, Bouchier C, Pazzani C, Mutreja A, Grunow R, Sidikou F, Bonte L, Breurec S, Damian M, Njanpop-Lafourcade BM, Sapriel G, Page AL, Hamze M, Henkens M, Chowdhury G, Mengel M, Koeck JL, Fournier JM, Dougan G, Grimont PAD, Parkhill J, Holt KE, Piarroux R, Ramamurthy T, Quilici ML, Thomson NR. Genomic history of the seventh pandemic of cholera in Africa. Science. 2017 Nov 10;358(6364):785-789. Pubmed
  2. Kumar P, Bag S, Ghosh TS, Dey P, Dayal M, Saha B, Verma J, Pant A, Saxena S, Desigamani A, Rana P, Kumar D, Sharma NC, Hanpude P, Maiti TK, Mukhopadhyay AK, Bhadra RK, Nair GB, Ramamurthy T, Das B. Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India. Sci Rep. 2017 Oct 31;7(1):14468.  Pubmed
  3. Ghosh P, Kumar D, Chowdhury G, Singh P, Samanta P, Dutta S, Ramamurthy T, Sharma NC, Sinha P, Prasad Y, Shinoda S, Mukhopadhyay AK. Characterization of Vibrio cholerae O1 strains that trace the origin of Haitian-like genetic traits. Infect Genet Evol. 2017 Oct;54:47-53.   Pubmed
  4. Yadav JP, Das SC, Dhaka P, Vijay D, Kumar M, Mukhopadhyay AK, Chowdhury G, Chauhan P, Singh R, Dhama K, Malik SVS, Kumar A. Molecular characterization and antimicrobial resistance profile of Clostridium perfringens type A isolates from humans, animals, fish and their environment. Anaerobe. 2017Oct;47:120-124.   Pubmed
  5. De R, Ramamurthy T, Sarkar BL, Mukhopadhyay AK, Pazhani GP, Sarkar S, Dutta S, Nair GB. Retrospective genomic analysis of Vibrio cholerae O1 El Tor strains from different places in India reveals the presence of ctxB-7 allele found in Haitian isolates. Epidemiol Infect.2017 Aug;145(11):2212-2220.  Pubmed
  6. Mukherjee P, Dutta S, Mukhopadhyay AK. Development and evaluation of a PCR assay for rapid detection of azithromycin resistant Campylobacter isolated from diarrhoeal patients in Kolkata, India. Gut Pathog. 2017 Jun 21;9:37.   Pubmed
  7. Singh R, Khatri P, Srivastava N, Jain S, Brahmachari V, Mukhopadhyay AK, Mazumder S. Fluoride exposure abates pro-inflammatory response and induces in vivo apoptosis rendering zebrafish (Daniorerio) susceptible to bacterial infections. Fish Shellfish Immunol.2017 Apr;63:314-321    Pubmed
  8. Ghosh N, Ghosh P, Kesh K, Mukhopadhyay AK, Swarnakar S. Attenuation of Helicobacter pylori-induced gastric inflammation by prior cag(-) strain (AM1) infection in C57BL/6 mice. Gut Pathog.2017 Mar 9;9:14.   Pubmed
  9. Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick JV, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host Microbe.2017 Mar 8;21(3):376-389   Pubmed
  10. Imamura D, Morita M, Sekizuka T, Mizuno T, Takemura T, Yamashiro T, Chowdhury G, Pazhani GP, Mukhopadhyay AK, Ramamurthy T, Miyoshi SI, Kuroda M, Shinoda S, Ohnishi M. Comparative genome analysis of VSP-II and SNPs reveals heterogenic variation in contemporary strains of Vibrio cholerae O1 isolated from cholera patients in Kolkata, India. PLoS Negl Trop Dis.2017 Feb 13;11(2):e0005386.   Pubmed

2016

  1. Chowdhury G., G.P. Pazhani, A. Sarkar, K. Rajendran, A.K. Mukhopadhyay, M.K. Bhattacharya, A. Ghosh and T. Ramamurthy. 2016. Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples. Emerg Infect Dis. 22: 1754-1761. Pubmed
  2. Chowdhury G., R.K. Bhadra, S. Bag, G.P. Pazhani, B. Das, P. Basu, K. Nagamani, R.K. Nandy, A.K. Mukhopadhyay and T. Ramamurthy. 2016. Rugose atypical Vibrio cholerae O1 El Tor responsible for 2009 cholera outbreak in India. J. Med. Microbiol. 65:1130-1136. Pubmed
  3. Mukhopadhyay A.K., K. Al Benwan, P. Samanta, G. Chowdhury and M.J. Albert. 2016. Vibrio cholerae O1 Imported from Iraq to Kuwait, 2015.Emerg Infect Dis. 22:1693-1694. Pubmed
  4. Ghosh R., N.C. Sharma, K. Halder, R.K. Bhadra, G. Chowdhury, G. P. Pazhani, S. Shinoda, A.K. Mukhopadhyay, G.B. Nair, and T. Ramamurthy. 2016. Phenotypic and Genetic Heterogeneity in Vibrio cholerae O139 Isolated from Cholera Cases in Delhi, India during 2001-2006. Front Microbiol. 7:1250. doi: 10.3389/fmicb.2016.01250. Pubmed
  5. Das B, G.P. Pazhani, A. Sarkar, A.K.Mukhopadhyay, G.B. Nair, and T. Ramamurthy. 2016. Molecular evolution and functional divergence of Vibrio cholerae. Curr Opin Infect Dis. 29:520-527. Pubmed
  6. Adewale AK, G. P. Pazhani, I.B. Abiodun, O. Afolabi, O.D. Kolawole, A. K.Mukhopadhyay and T. Ramamurthy. 2016. Unique Clones of Vibrio cholerae O1 El Tor with Haitian Type ctxB Allele implicated in the Recent Cholera Epidemics from Nigeria, Africa. PLoS One. 11(8):e0159794. Pubmed
  7. Bhattacharya S., O. Mukherjee, A.K. Mukhopadhyay and R. Chowdhury. 2016. A conserved Helicobacter pylori gene HP0102 is induced upon contact with gastric cells and has multiple roles in pathogenicity. J Infect Dis. 214:196-204. Pubmed
  8. Gehlot V, S. Mahant, A.K. Mukhopadhyay, K. Das, R. De, P. Kar and R. Das. 2016. Antimicrobial susceptibility profiles of Helicobacter pylori isolated from patients in North India. J Global Antimicrob Resistance.5:51-56. Pubmed
  9. Dey S.K., P.K. De, A. De, S. Ojha, R. De, A.K. Mukhopadhyay and A. Samanta. 2016. Floating mucoadhesive alginate beads of amoxicillin trihydrate: A facile approach for H. pylori eradication. Int J BiolMacromol. 89:622-631 Pubmed
  10. Das L., S.B. Kokate, S. Rath, N. Rout, S.P. Singh, S.E. Crowe, A.K. Mukhopadhyay, A. Bhattacharyya. 2016. ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2. Biochem J.473:1629-40 Pubmed
  11. Mukherjee P., S. Raychaudhuri, D. Nag, R. Sinha, D. R. Howlader, A.K. Mukhopadhyay and H. Koley. 2016.Evaluation of immunogenicity and protective efficacy of combination heat-killed immunogens from three entero-invasive bacteria in rabbit model. Immunobiology 221:918-26 Pubmed
  12. Verma V, A. Kumar, R.G. Nitharwal, J. Alam, A.K. Mukhopadhyay, S. Dasgupta, S.K. Dhar. 2016. Modulation of the enzymatic activities of replicative helicase (DnaB) by interaction with Hp0897: a possible mechanism for helicase loading in Helicobacter pylori. Nucleic Acids Res. 3288-303Pubmed Pubmed
  13. Ganguly M., S. Sarkar, P. Ghosh, A. Sarkar, J. Alam, B.C. Karmakar, R. De, D.R. Saha, and A.K. Mukhopadhyay. 2016.Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India. Gut Pathog. 22;8:10. Pubmed
  14. Sarkar A., R. De, A.K. Mukhopadhyay. 2016. Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases. World J Gastroenterol. 22:2736-48. Pubmed
  15. Gehlot V, S. Mahant, A.K. Mukhopadhyay, K. Das, J. Alam, P. Ghosh and R. Das. 2016. Low prevalence of clarithromycin-resistant Helicobacter pylori isolates with A2143G point mutation in the 23S rRNA gene in North India. J Global Antimicrob Resistance. 6: 39-43.
  16. Ghosh P., A. Sarkar, M. Ganguly, Raghwan, J. Alam, R. De, A. K. Mukhopadhyay. 2016. Helicobacter pylori strains harboring babA2 from Indian sub population are associated with increased virulence in ex vivo study. Gut Pathog. 8:1 Pubmed

2015

  1. Alam J., P. Ghosh, M. Ganguly, A. Sarkar, R. De, A. K. Mukhopadhyay. 2015. Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population. Gut Pathog.7:9 Pubmed
  2. Mukhopadhyay A. K. 2015. Mapping of cholera cases using satellite based recording systems to investigate the outbreak. Indian J Med Res. 142:509-511. Pubmed
  3. Payne A., A. K. Mukhopadhyay, S. Deka, L. Saikia, S. Paul Nandi. 2015. Anti-Vibrio and antioxidant properties of two weeds: Euphorbia serpens and Amaranthus viridis. Res. J. Med. Plant 9:170-178
  4. Samanta P., P. Ghosh, G. Chowdhury, T. Ramamurthy, A. K. Mukhopadhyay. 2015. Sensitivity to Polymyxin B in El Tor Vibrio cholerae O1 strain, Kolkata, India. Emerg Infect Dis. 21:2100-2102. Pubmed
  5. Shetty V., M. Ballal, R. Lingadakai, A. K. Mukhopadhyay. 2015. Determination of Helicobacter pylori virulence genes in clinical isolates of symptomatic patients from south coastal region of Karnataka - a preliminary work. Austin J Gastroenterol. 2:1031.
  6. Sinha R., H. Koley, D. Nag, A. Mitra, A. K. Mukhopadhyay, B. D. Chatterjee. 2015.Pentavalent outer membrane vesicles of Vibrio cholerae induce adaptive immune response and protective efficacy in both adult and passive suckling mice model. Microbes Infect. 17:215-227. Pubmed

2014

  1. Ghosh P., A. Naha, G. P. Pazhani, T. Ramamurthy, and A. K.Mukhopadhyay. 2014.Genetic Traits of Vibrio cholerae O1 Haitian isolates that are absent in contemporary strains from Kolkata, India. PLoS One9(11): e112973 Pubmed
  2. Pazhani G. P., S. K. Bhowmik, S. Ghosh, S. Guin, S. Dutta, K. Rajendran, D. R. Saha, R. K. Nandy, M. K. Bhattacharya, A. K.Mukhopadhyay, and T. Ramamurthy. 2014. Trends in the epidemiology of pandemic and non-pandemic strains of Vibrio parahaemolyticus isolated from diarrheal patients in Kolkata, India. PLoSNegl Trop Dis.:e2815 Pubmed
  3. Mukherjee P, T. Ramamurthy, U. Mitra, and A. K. Mukhopadhyay. 2014 Emergence of high-level azithromycin resistance in Campylobacter jejuni isolated from PaediatricDiarrhoea cases in Kolkata, India. Antimicrob Agents Chemother58:4248. Pubmed
  4. Koley H., N. Ray, G. Chowdhury, S. Barman, S. Mitra, T. Ramamurthy, A. K. Mukhopadhyay, B. L. Sarkar, R. Katyal., P. Das, S. Panda, and S. Ghosh. 2014. An Outbreak of Cholera Caused by a single clone of Vibrio cholerae O1 El Tor Variant Strain in Bihar, India, Jpn J Infect Dis.67:221-226. Pubmed
  5. Ghosh P., A. Naha, S. Basak, S. Ghosh, T. Ramamurthy, H. Koley, R.K. Nandy, S. Shinoda, H. Watanabe, A. K. Mukhopadhyay. 2014. Haitian Variant tcpA in Vibrio cholerae O1 El Tor strains of Kolkata, India. J Clin Microbiol. 52:1020-1021. Pubmed

2013

  1. Chowdhury, G., A. Sarkar, G. P. Pazhani, A. K. Mukhopadhyay, M. K. Bhattacharya and T. Ramamurthy. 2013. An Outbreak of Foodborne Gastroenteritis Caused by Dual Pathogens, Salmonella enterica serovar Weltevreden and Vibrio fluvialis in Kolkata, India. Foodborne Pathogens and Dis. 10:904-906 Pubmed
  2. Mukherjee, P., T. Ramamurthy, M. K. Bhattacharya, K. Rajendran, and A. K. Mukhopadhyay. 2013. Campylobacter jejuni in Hospitalized patients with Diarrhea, Kolkata, India. Emerg Infect Dis.19:1155-1156 Pubmed
  3. Naha, A., G. Chowdhury, J. Ghosh-Banerjee, M. Senoh, T. Takahashi, B. Ley, K. Thriemer, J. Deen, L. V. Seidlein, S. M. Ali, A. Khatib, T. Ramamurthy, R.K. Nandy, G.B. Nair, Y. Takeda and A.K. Mukhopadhyay. 2013. Molecular Characterization of High Cholera Toxin-Producing El Tor Variant Vibrio cholerae in the Zanzibar Archipelago of Tanzania. J Clin Microbiol. 51:1040-1045. Pubmed
  4. Sinha, A., S. Sengupta, S. Guin, S. Dutta, S. Ghosh, P. Mukherjee, A.K. Mukhopadhyay, T. Ramamurthy, Y. Takeda, T. Kurakawa, K. Nomoto, G.B. Nair, and R.K. Nandy. 2013. Culture-independent real-time PCR reveals extensive polymicrobial infections in hospitalized diarrhoea cases in Kolkata, India. Clin Microbiol Infect. 19:173-180. Pubmed
  5. Chowdhury, G., S. Ghosh, G. P. Pazhani, B. K. Paul, D. Maji, A. K. Mukhopadhyay, and T. Ramamurthy 2013. Isolation and Characterization of Pandemic and Non-pandemic Strains of Vibrio parahaemolyticus from an Outbreak of Diarrhea in North 24 Parganas, West Bengal, India. Foodborne Pathogens and Dis. 10:338-342. Pubmed
  6. Dutta, D., G. Chowdhury, G. P. Pazhani, S. Guin, S. Dutta, S. Ghosh, K. Rajendran, R. K. Nandy, A. K. Mukhopadhyay, M. K. Bhattacharya, U. Mitra, Y. Takeda, G. B. Nair, and T. Ramamurthy. 2013. Vibrio cholerae Non-O1, Non-O139 Serogroups and Cholera-like Diarrhea, Kolkata, India. Emerg Infect Dis. 19:464-467. Pubmed

2012

  1. Ley B, AM Khatib, K. Thriemer, L. von Seidlein, J. Deen, A.K. Mukhopadhyay , N.Y. Chang, R. Hashim, W. Schmied, C.J. Busch, R. Reyburn, T. Wierzba, J.D. Clemens, H. Wilfing, G. Enwere, T. Aguado, M.S. Jiddawi, D. Sack, S.M. Ali. 2012. Evaluation of a rapid dipstick (Crystal VC) for the diagnosis of cholera in Zanzibar and a comparison with previous studies. PLoS One; 7(5):e36930. Pubmed
  2. Kumar N, A. K. Mukhopadhyay, R. Patra, R. De, R. Baddam, S. Shaik, J. Alam, S. Tiruvayipati, N. Ahmed. 2012. Next-Generation Sequencing and De Novo Assembly, Genome Organization, and Comparative Genomic Analyses of the Genomes of Two Helicobacter pylori Isolates from Duodenal Ulcer Patients in India. J Bacteriol. 194: 5963-5964. Pubmed
  3. Chowdhury G, G.P. Pazhani, D. Dutta, S. Guin, S. Dutta, S. Ghosh, H. Izumiya, M. Asakura, S. Yamasaki, Y. Takeda, E. Arakawa, H. Watanabe, A.K. Mukhopadhyay, M.K. Bhattacharya, K. Rajendran, G.B. Nair and T. Ramamurthy. 2012. Vibrio fluvialis in Patients with Diarrhea, Kolkata, India. Emerg Infect Dis. 18: 1868-1871 Pubmed
  4. Khatib AM, M. Ali, L. von Seidlein, D.R. Kim, R. Hashim, R. Reyburn, B. Ley, K. Thriemer, G. Enwere, R. Hutubessy, M.T. Aguado, M.P. Kieny, A.L. Lopez, T.F. Wierzba, S.M. Ali SM, A.A. Saleh, A.K. Mukhopadhyay, J. Clemens, M.S. Jiddawi, J. Deen. 2012 Effectiveness of an oral cholera vaccine in Zanzibar: findings from a mass vaccination campaign and observational cohort study.. Lancet Infect Dis.12:837-844 Pubmed
  5. Patra R., S. Chattopadhyay, R. De, P. Ghosh, M. Ganguly, A. Chowdhury, T. Ramamurthy, G. B. Nair, and A. K. Mukhopadhyay. 2012. Multiple infection and microdiversity among Helicobacter pylori isolates in a single host in India. PLoS ONE 7: e43370 Pubmed
  6. Kumar, R., A.K. Mukhopadhyay, P. Ghosh and D. N. Rao. 2012. Comparative transcriptomics of Helicobacter pylori strains 26695 ?hp0051 and AM5?hp0051: Possible roles of cytosine methylation in gene regulation. PLoS ONE 7: e42303. Pubmed
  7. Alam J, S. Maiti S, P. Ghosh, R. De, A. Chowdhury, S. Das, R. Macaden, H. Devarbhavi, T. Ramamurthy, A. K. Mukhopadhyay. 2012. Significant association of dupA of Helicobacter pylori with duodenal ulcer development in South East Indian population. J Med Microbiol. 61:1295-1302. Pubmed
  8. Kumar R., V. Sabareesh, A.K. Mukhopadhyay, and D.N. Rao. 2012. Mutations in hpyAVIBM, C(5) cytosine DNA methyltransferase from Helicobacter pylori result in relaxed specificity. FEBS J. 279:1082-1092 Pubmed
  9. Chattopadhyay S, R. Patra, R. Chatterjee, R. De, J. Alam, T. Ramamurthy, A. Chowdhury, G. B. Nair, D. E. Berg, and A. K. Mukhopadhyay. 2012. Distinct repeat motifs at the C-terminal region of CagA of Helicobacter pylori strains isolated from diseased patients and asymptomatic individuals in West Bengal, India. Gut Pathogens.4:4. Pubmed
  10. Sinha, A, S. SenGupta, S. Ghosh, S. Basu, D. Sur, S. Kanungo, A.K. Mukhopadhyay, T. Ramamurthy, K. Nagamani, Narsing Rao M. and R.K. Nandy. 2012. Evaluation of a rapid dipstick test for identifying cholera cases during the outbreak. Indian J Med Res. 135: 523-528. Pubmed
  11. Naha A., G.P. Pazhani, M. Ganguly, S. Ghosh, T. Ramamurthy, R.K. Nandy, G.B. Nair, Y. Takeda, and A. K. Mukhopadhyay. 2012. Development and Evaluation of a PCR Assay for Tracking the Emergence and Dissemination of Haitian Variant ctxB in Vibrio cholerae O1 Strains Isolated from Kolkata, India. J. Clin. Microbiol. 50: 1733-1736. Pubmed
  12. Kurakawa T., H. Kubota, H. Tsuji, K. Matsuda, T. Asahara, T. Takahashi, T. Ramamurthy, T. Hamabata, E. Takahashi, S.I. Miyoshi, K. Okamoto, A.K. Mukhopadhyay, Y. Takeda, and K. Nomoto. 2012. Development of a sensitive rRNA-targeted reverse transcription-quantitative polymerase chain reaction for detection of Vibrio cholerae/mimicus, V. parahaemolyticus/alginolyticus and Campylobacter jejuni/coli. Microbiol. Immunol. 56: 10-20. Pubmed
  13. Bhuiyan N.A., S. Nusrin, M. Ansaruzzaman, A. Islam, M. Sultana, M. Alam, M.A. Islam, A. Cravioto, A. K. Mukhopadhyay, G. B. Nair, J.C.L. Mwansa and H. P. Endtz. 2012. Genetic characterization of Vibrio cholerae O1 strains isolated in Zambia during 1996-2004 possessing the unique VSP-II region of El Tor variant. Epidemiol. Infect. 140: 510-518. Pubmed

2011

  1. Mehrotra, S., R. Jamwal, R. Shyam, D. K. Meena, K. Mishra, R. Patra, R. De, A.K. Mukhopadhyay, A.K. Srivastava, S. Paul Nandi. 2011. Anti-Helicobacter pylori and antioxidant properties of Emblica officinalis pulp extract; a potential source for therapeutic use against gastric ulcer. J Med Plants Res. 5:2577-2583.
  2. Kundu P., R. De, I. Pal, A.K. Mukhopadhyay D.R. Saha, S. Swarnakar. 2011. Curcumin Alleviates Matrix Metalloproteinase-3 and -9 Activities During Eradication of Helicobacter pylori Infection in Cultured Cells and Mice. PLoS One 6:e 16306. Pubmed
  3. Patra R., S. Chattopadhyay, R. De, S. Datta, A. Chowdhury, T. Ramamurthy, G. B. Nair, D. E. Berg, and A. K. Mukhopadhyay. 2011. Intact cag Pathogenicity Island of Helicobacter pylori without Disease Association in Kolkata, India. Int. J Med Microbiol. 301: 293-302. Pubmed
  4. Patra T., S. Chatterjee, A. Raychoudhuri, A. K. Mukhopadhyay, T. Ramamurthy, R.K. Nandy. 2011. Emergence andprogressionof Vibrio cholerae O1 ElTor variants and progenitor strains of Mozambique variants in Kolkata, India. Int. J Med Microbiol. 301: 310-317. Pubmed

2010

  1. Ghosh-Banerjee, J., M. Senoh, T. Takahashi, T. Hamabata, S. Barman, H. Koley, A. K. Mukhopadhyay, T. Ramamurthy, S. Chatterjee, M. Asakura, S. Yamasaki, G.B. Nair, and Y. Takeda. 2010. Cholera toxin production by El Tor variant of Vibrio cholerae O1 as compared to prototype El Tor and classical biotypes. J Clin Microbiol. 48: 4283-4286. Pubmed
  2. Mukherjee P., S. Ghosh, T. Ramamurthy, M. K. Bhattacharya, R. K. Nandy, Y. Takeda, G. B. Nair and A. K. Mukhopadhyay. 2010. Evaluation of a rapid immunochromatographic dipstick kit for the diagnosis of cholera emphasizes its outbreak utility. Jpn. J. Infect. Dis. 63: 234-238. Pubmed
  3. Albert M.J., H. M. Al-Akbal, R. Dhar, R. De, and A.K. Mukhopadhyay. 2010. Genetic affinities of Helicobacter pylori isolates from ethnic Arabs in Kuwait. Gut Pathog. 2: 1-6. Pubmed
  4. Kumar R., A. K. Mukhopadhyay and D.N. Rao. 2010. Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand. FEBS J. 277:1666-1683. Pubmed
  5. Raychoudhuri, A., P. Mukherjee, T. Ramamurthy, R.K. Nandy, Y. Takeda, G.B. Nair and A. K. Mukhopadhyay. 2010. Genetic analysis of CTX prophages with special reference to ctxB and rstR alleles of Vibrio cholerae O139 strains isolated from Kolkata over a decade. FEMS Microbiol Lett 303:107-115. Pubmed

2009

  1. Chatterjeem, S., K. Ghosh, A. Raychoudhuri, G. Chowdhury, M. K. Bhattacharya, A. K. Mukhopadhyay, T. Ramamurthy, S. K. Bhattacharya, K. E. Klose, R. K. Nandy. 2009. Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India. J Clin Microbiol. 47: 1087-95. Pubmed
  2. De, R., P. Kundu, S. Swarnakar, T. Ramamurthy, A. Chowdhury, G. B. Nair and A. K. Mukhopadhyay. 2009. Antimicrobial activity of curcumin against Indian Helicobacter pylori and also during mice infection. J. Antimicrob. Chemother. 53: 1592-1597. Pubmed
  3. Saha, D. R., S. Datta, S. Chattopadhyay, R. Patra, R. De, K. Rajendran, A. Chowdhury, T. Ramamurthy and A. K. Mukhopadhyay. 2009. Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribals and duodenal ulcer patients. World J. Gastroenterology. 15: 1105-1112. Pubmed
  4. Chatterjeem, S., T. Patra, K. Ghosh, A. Raychoudhuri, G. P. Pahzani, M. Das, B. L. Sarkar, R. K. Bhadra, A. K. Mukhopadhyay, Y. Takeda, G. B. Nair, T. Ramamurthy and R. K. Nandy. 2009. Vibrio cholerae O1 clinical strains of 1992 at Kolkata with progenitor traits of 2004 Mozambique variant. J. Med. Microbiol. 58: 239-247. Pubmed
  5. Raychoudhuri, A., A. K. Mukhopadhyay, T. Ramamurthy, R. K. Nandy, Y. Takeda and G. B. Nair. 2008. Biotyping of Vibrio cholerae O1: Time to Redefine the Scheme. Ind J. Med Res. 128: 695-698. Pubmed
  6. Raychoudhuri, A., T. Patra, K. Ghosh, T. Ramamurthy, R. K. Nandy, Y. Takeda, G. B. Nair and A. K. Mukhopadhyay. 2009. Classical ctxB in Vibrio cholerae O1, Kolkata, India. Emerging Infect Dis. 15: 131-132. Pubmed

2008

  1. Raychoudhuri, A., A. K. Mukhopadhyay, T. Ramamurthy, R. K. Nandy, Y. Takeda and G. B. Nair. 2008. Biotyping of Vibrio cholerae O1: Time to Redefine the Scheme. Ind J. Med Res. 128: 695-698. Pubmed
  2. Chakraborty, K., S. Ghosh, H. Koley, A. K. Mukhopadhyay, T. Ramamurthy, D. R. Saha, D. Mukhopadhyay, S. Roychowdhury, T. Hamabata, Y. Takeda and S. S. Das. 2008. Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human beta-defensin 1 (HBD-1) expression in the intestinal epithelial cells. Cell. Microbiol. 10: 2520-2537. Pubmed
  3. Khan, R., S. Nahar, A. K. Mukhopadhyay, D. E. Berg, M. Ahmad, K. Okamoto, G. B. Nair and M. Rahman. 2008. Isolation of tetracycline-resistant clinical Helicobacter pylori in Bangladesh without mutations in 16S rRNA gene. Microbiol. Immunol. 52: 508-511. Pubmed
  4. Hisatsune, J., M. Nakayama, H. Isomoto, H. Kurazono, N. Mukaida, A. K. Mukhopadhyay, T. Azuma, Y. Yamaoka, J. Sap, E. Yamasaki, K. Yahiro, J. Moss and T. Hirayama. 2008. Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-{kappa}B Activation. J. Immunol. 180: 5017-5027. Pubmed
  5. Roychowdhury, A., A. Pan, D. Dutta, A. K. Mukhopadhyay, T. Ramamurthy, R. K. Nandy, S. K. Bhattacharya and M. K. Bhattacharya. 2008. Emergence of Tetracycline-Resistant Vibrio cholerae O1 Serotype Inaba, in Kolkata, India. Jpn. J. Infect. Dis. 61: 128-129. Pubmed

2007

  1. Raychoudhuri, A., S. Chatterjee, G. P. Pazhani, R. K. Nandy, M. K. Bhattacharya, S. K. Bhattacharya, T. Ramamurthy and A. K. Mukhopadhyay. 2007. Molecular characterization of recent Vibrio cholerae O1, El Tor, Inaba strains isolated from hospitalized patients in Kolkata, India during 2004-05. J. Infect. 55: 431-438. Pubmed
  2. Chatterjee, S., K. Ghosh, A. Raychoudhuri, A. Pan, M. K. Bhattacharya, A. K. Mukhopadhyay, T. Ramamurthy, S. K. Bhattacharya and R. K. Nandy. 2007. Phenotypic and genotypic traits and epidemiologic implication of Vibrio cholerae O1 and O139 strains in India during 2003. J. Med. Microbiol. 56: 824-832. Pubmed
  3. Sen, B., B. Dutta, S. Chatterjee, M. K. Bhattacharya, R. K. Nandy, A. K. Mukhopadhyay, B. D. N. Gangopadhyay, S. K. Bhattacharya and T. Ramamurthy. 2007. The first outbreak of acute diarrhea due to pandemic strain of Vibrio parahaemolyticus O3:K6 in Kolkata, India. Internal. J. Infect. Dis. 11: 185-187. Pubmed

2006

  1. Kundu, P., A. K. Mukhopadhyay, R. Patra, A. Banerjee, D. E. Berg and S. Swarnakar. 2006. Cag pathogenicity island-independent up-regulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by Helicobacter pylori infection. J. Biol. Chem. 281: 34651-34662. Pubmed
  2. Srinivasan, V. B., R. K. Virk, A. Kaundal, R. Chakraborty, B. Datta, T. Ramamurthy, A. K. Mukhopadhyay and A. Ghosh. 2006. Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India. Antimicrob. Agents Chemother. 50: 2428-2432. Pubmed
  3. Dutta, B., R. Ghosh, N. C. Sharma, G. P. Pazhani, N. Taneja, A. Raychowdhuri, B. L. Sarkar, S. K. Mondal, A. K. Mukhopadhyay, R. K. Nandy, M. K. Bhattacharya, S. K. Bhattacharya and T. Ramamurthy. 2006. Spread of cholera with newer clones of Vibrio cholerae O1 El Tor, serotype inaba, in India. J. Clin Microbiol. 44: 3391-3393. Pubmed
  4. Chakraborty, R., S. Sinha, A. K. Mukhopadhyay, M. Asakura, S. Yamasaki, S. K. Bhattacharya, G. B. Nair and T. Ramamurthy. 2006. Species-specific identification of Vibrio fluvialis by PCR targeted to the conserved transcriptional activation and variable membrane tether regions of toxR gene. J. Med. Microbiol. 55: 805-808. Pubmed
  5. Saha, A., R. Deb, S. Shah, T. Ramamurthy, S. Shinoda, A. K. Mukhophadyay and R. K. Bhadra. 2006. A PCR based identification of Vibrio cholerae, its biotypes and closely related Vibrio mimicus targeting the chromosomal origin of replication (oriCIVC) of V. cholerae. FEMS. Micrbiol. Lett. 257: 84-91. Pubmed

2005

  1. Datta, S., S. Chattopadhyay, A. Chowdhury, A. Santra, D. R. Saha, T. Ramamurthy, S. K. Bhattacharya, D. E. Berg, G. B. Nair and A. K. Mukhopadhyay. 2005. Diagnosis and genotyping of Helicobacter pylori by polymerase chain reaction of bacterial DNA from gastric juice. J. Gastroenterol. Hepatol. 20: 1253-1259. Pubmed
  2. Datta, S., S. Chattopadhyay, R. Patra, R. De, T. Ramamurthy, J. Hembram, A. Chowdhury, S. K. Bhattacharya, D. E. Berg, G. B. Nair and A. K. Mukhopadhyay. 2005. Most Helicobacter pylori strains of Kolkata in India are resistant to metronidazole but susceptible to other drugs commonly used for eradication and ulcer therapy. Aliment. Pharmacol. Ther. 22: 51-57. Pubmed
  3. Chakraborty, R., S. Chakraborty, K. De, S. Sinha, A. K. Mukhopadhyay, J. Khanam, T. Ramamurthy, Y. Takeda, S. K. Bhattacharya and G. B. Nair. 2005. Cytotoxic and cell vacuolating activity of Vibrio fluvialis isolated form paediatric patients with diarrhoea. J. Med. Microbiol. 54: 707-716. Pubmed

2004

  1. Kalia, A., A. K. Mukhopadhyay, G. Dailide, Y. Ito, T. Azuma, B. C. Wong and D. E. Berg. 2004. Evolutionary Dynamics of Insertion Sequences in Helicobacter pylori. J. Bacteriol. 186: 7508-7520. Pubmed
  2. Nahar, S., A. K. Mukhopadhyay, R. Khan, M. M. Ahmad, S. Datta, S. Sarker, L. Engstrand, S. Ahmed, D. E. Berg, G. B. Nair and M. Rahman. 2004. Antimicrobial susceptibility of Helicobacter pylori strains isolated from Bangladesh. J. Clin. Microbiol. 42: 4856-4858. Pubmed
  3. Chattopadhyay, S., R. Patra, T. Ramamurthy, A. Chowdhury, A. Santra, G. K. Dhali, S. K. Bhattacharya, D. E. Berg, G. B Nair and A. K. Mukhopadhyay. 2004. Multiplex PCR assay for rapid detection and genotyping of Helicobacter pylori directly from biopsy specimens. J. Clin. Microbiol. 42: 2821-2824. Pubmed
  4. Dailidiene, D., G. Dailide, M. Zhang, A. K. Mukhopadhyay, K. Ogura, K. A. Eaton, G. Cattoli, J. G. Kusters and D. E. Berg. 2004. Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big cats. J. Bacteriol. 186: 356-365. Pubmed

2003

  1. Datta, S., S. Chattopadhyay, G. B. Nair, A. K. Mukhopadhyay, J. Hembram, D. E. Berg, D. R. Saha, A. Khan, A. Santra, S. K. Bhattacharya and A. Chowdhury. 2003. Virulence genes and neutral DNA markers of Helicobacter pylori isolates from different ethnic communities of West Bengal, India. J. Clin. Microbiol. 41: 3737-3743. Pubmed
  2. Kersulyte, D., B. Velapatino, A. K. Mukhopadhyay, L. Cahuayme, A. Bussalleu, J. Combe, R. H. Gilman and D. E. Berg. 2003. Cluster of type IV secretion genes in Helicobacter pylori's plasticity zone. J. Bacteriol. 185: 3764-3772. Pubmed
  3. Rahman, H., A. K. Mukhopadhyay, S. Nahar, S. Datta, M. Mian, S. Sarker, I. M. Masud, L. Engstrand, M. J. Albert, G. B. Nair and D. E. Berg. 2003. DNA-level characterization of Helicobacter pylori strains from patients with overt disease and with benign infections in Bangladesh. J. Clin. Microbiol. 41: 2008-2014. Pubmed
  4. Mukhopadhyay, A. K., J. Y. Jeong, D. Dailidiene, P. S. Hoffman and D. E. Berg. 2003. The fdxA ferredoxin gene can down-regulate frxA nitroreductase gene expression and is essential in many strains of Helicobacter pylori. J. Bacteriol. 185: 2927-2935. Pubmed
  5. Chaudhuri, S., A. Choudhury, S. Datta, A. K. Mukhopadhyay, S. Chattopadhyay, D. R. Saha, G. Dhali, A. Santra, G. B. Nair, S. K. Bhattacharya and D. E. Berg. 2003. Anti - Helicobacter pylori therapy in India: Differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J. Gastroenterol. Hepatol. 18: 190-195. Pubmed

2002

  1. Chattopadhyay, S., S. Datta, A. Chowdhury, S. Chowdhury, A. K. Mukhopadhyay, K. Rajendran, S. K. Battacharya, D. E. Berg and G. B. Nair. 2002. Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers. J. Clin. Microbiol. 40: 2622-2625. Pubmed
  2. Dailidiene, D., M. T. Bertoli, J. Miciuleyiciene, A. K. Mukhopadhyay, G. Dailide, M. A. Pascasio, L. Kupcinskas and D. E. Berg. 2002. Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S ribosomal DNA and other genetic loci. Antimicrob. Agents Chemother. 46: 3940-3946. Pubmed
  3. Sisson, G., A. Goodwin, A. Raudonikiene, N. J. Hughes, A. K. Mukhopadhyay, D. E. Berg and P. S. Hoffman. 2002. Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans and metronidazole in Helicobacter pylori. Antimicrob. Agents Chemother. 46: 2116-2123. Pubmed
  4. Datta, S., A. Chowdhury, A. K. Mukhopadhyay, S. K. Bhattacharya, D. E. Berg and G. B. Nair. 2002. Molecular and evolutionary genetics of the gastric pathogen, Helicobacter pylori. Ind. J. Med. Res. 115: 73-101. Pubmed
  5. Chowdhury, A., D. E .Berg, J. Y. Jeong, A. K. Mukhopadhyay and G. B. Nair. 2002. Metronidazole resistance in Helicobacter pylori: Magnitude, Mechanism and Implications for India. Indian J. Gastroenterol. 21: 23-28. Pubmed
  6. Kersulyte, D., B. Velapatiño, G. Dailide, A. K. Mukhopadhyay, Y. Ito, L. Cahuayme, A. J. Parkinson, R. H. Gilman and D. E. Berg. 2002. Transposable element ISHp608 of Helicobacter pylori: non-random geographic distribution, functional organization and insertion specificity. J. Bacteriol. 184: 992-1002. Pubmed

2001

  1. Datta, S., H. Kurazono, S. Chattopadhyay, A. Chowdhury, S. Chaudhury, S. K. Bhattacharya, A. K. Mukhopadhyay, D. E. Berg, T. Hirayama and G. B. Nair. 2001. Estimation of vacuolating cytotoxin secreted by different strains of Helicobacter pylori using bead-enzyme linked immunosorbent assay and its correlation with bacterial genotype. Indian J. Med. Res. 114: 192-198. Pubmed
  2. Jeong, J. Y., A. K. Mukhopadhyay, D. Daillidiene, P. S. Hoffman and D. E. Berg. 2001. Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole. J. Bacteriol. 183: 5155-5162. Pubmed
  3. Mukhopadhyay, A. K., S. Chakraborty, S. T. Shimada, Y. Takeda, G. B. Nair and D. E. Berg. 2001. Characterization of CTX and VPI prophages in environmental strains of Vibrio choleare. J. Bacteriol. 183: 4737-4746. Pubmed

2000

  1. Wang, W. H., B. C. Wong, A. K. Mukhopadhyay, D. E. Berg, C. H. Cho, K. C. Lai, W. H. Hu, F. M. Fung, W. M. Hui and S. K. Lam. 2000. High prevalence of Helicobacter pylori infection with dual resistance to metronidazole and clarithromycin in Hong Kong. Aliment. Pharmacol. Ther. 14: 901-910. Pubmed
  2. Kersulyte, D., A. K. Mukhopadhyay, M. Shirai, T. Nakazawa and D. E. Berg. 2000. Functional organization and insertion specificity of IS607, a chimaeric element of Helicobacter pylori. J. Bacteriol. 182: 5300-5308. Pubmed
  3. Jeong, J. Y., A. K. Mukhopadhyay, D. Daillidiene, Y. Wang, B. Velapatino, R. H. Gilman, A. J. Perkinson, G. B. Nair, B. Wong, S. K. Lam, R. Mistry, I. Segal, Y. Yuan, H. Gao, T. Alarcon, M. L. Brea, Y. Ito, D. Kersulyte, H. K. Lee, Y. Gong, A. Goodwin, P. S. Hoffman and D. E. Berg. 2000. Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori. J. Bacteriol. 182: 5082-5090. Pubmed
  4. Kersulyte, D., A. K. Mukhopadhyay, B. Velapatiño, W. W. Su, Z. J. Pan, C. Garcia, V. Hernandez, Y. Valdez, R. S. Mistry, R. H. Gilman, Y. Yuan, H. Gao, T. Alarcon, M. Lopez Brea, G. B. Nair, A. Chowdhury, S. Datta, M. Shirai, T. Nakazawa, R. Ally, I. Segal, B. C. Y. Wong, S. K. Lam, F. Olfat, T. Boren, L. Engstrand, O. Torres, R. Schneider, J. E. Thomas, S. Czinn and D. E. Berg. 2000. Differences in Genotypes of Helicobacter pylori from Different Human Populations. J. Bacteriol. 182: 3210-3218. Pubmed
  5. Mitra, R., P. Figueroa, A. K. Mukhopadhyay, T. Shimada, Y. Takeda, D. E. Berg and G. B. Nair. 2000. Cell vacuolation, a manifestation of the El tor hemolysin of vibrio cholerae. Infect. Immun. 68: 1928-1933. Pubmed
  6. Mukhopadhyay, A. K., D. Kersulyte, J. Y. Jeong, S. Datta, Y. Ito, A. Chowdhury, S. Chowdhury, A. Santra, S. K. Bhattacharya, T. Azuma, G. B. Nair and D. E. Berg. 2000. Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J. Bacteriol. 182: 3219-3227. Pubmed
  7. Chakraborty, S., A. K. Mukhopadhyay, R. K. Bhadra, A. N. Ghosh, R. Mitra, T. Shimada, S. Yamasaki, S. M. Faruque, Y. Takeda, R. R. Colwell and G. B. Nair. 2000. Virulence genes in environmental strains of Vibrio cholerae. Appl. Environ. Microbiol. 66: 4022-4028. Pubmed
  8. Basu, A., A. K. Mukhopadhyay, P. Garg, S. Chakraborty, T. Ramamurthy, S. Yamasaki, Y. Takeda and G. B Nair. 2000. Diversity in the arrangement of the, CTX prophages in Classical Strains of Vibrio cholerae O1. FEMS. Microbiol. Lett. 182: 35-40. Pubmed
  9. Bhattacharya, M. K., S. Ghosh, A. K. Mukhopadhyay, A. Deb and S. K. Bhattacharya. 2000. Outbreak of cholera caused by Vibrio cholerae 01 intermediately resistant to norfloxacin at Malda, West Bengal. J. Ind. Med. Assoc. 98: 389-390. Pubmed

1999

  1. Thungapathra, M., C. Sharma, N. Gupta, R. K. Ghosh, A. K. Mukhopadhyay, H. Koley, G. B. Nair and A. Ghosh. 1999. Construction of a recombinant live oral vaccine from a non-toxigenic strain of Vibrio cholerae O1 serotype Inaba biotype El Tor and assessment of its reactogenicity and immunogenicity in the rabbit model. Immunol. Lett. 68: 219-227. Pubmed
  2. Koley, H., R. Mitra, A. Basu, A. K. Mukhopadhyay, P. K. Saha, B. S. Ramakrishna, S. Krishnan, Y. Takeda and G. B. Nair. 1999. Response of wild type mutants of Vibrio cholerae O1 possessing different combination of virulence genes in the ligated rabbit ileal loop and in ussing chambers: Evidence for the presence of additional secretogen. J. Med. Microbiol. 48: 51-57. Pubmed

1998

  1. Hoshino, K., S. Yamazaki, A. K. Mukhopadhyay, S. Chakravarty, A. Basu, S. K. Bhattacharya, G. B. Nair, T. Shimada and Y. Takeda. 1998. Development and evaluation of a multiplex PCR assay for rapid detection of toxigenic Vibrio cholerae O1 and O139. FEMS Microbiol. Immunol. 20: 201-207. Pubmed
  2. Sharma, C., M. Thungapathra, A. Ghosh, A. K. Mukhopadhyay, A. Basu, R. Mitra, I. Basu, S. K. Bhattacharya, T. Shimada, T. Ramamurthy, T. Takeda, S. Yamasaki, Y. Takeda and G. B. Nair. 1998. Molecular analysis of non-O1 non-O139 Vibrio cholerae associated with an unusual upsurge in the incidence of cholera-like diseases in Calcutta, India. J. Clin. Microbiol. 36: 756-763. Pubmed
  3. Sharma, C., A. Ghosh, R. K. Ghosh, A. K. Mukhopadhyay and G. B. Nair. 1998. Molecular analysis of the cholera toxin gene antibiotic sensitivity profile of vibrio cholerae O1 O139 associated with mixed infection. Indian J. Med. Res. 107: 199-203. Pubmed
  4. Basu, A., A. K. Mukhopadhyay, C. Sharma, J. Jyot, N. Gupta, A. Ghosh, S. K. Bhattacharya, Y. Takeda, A. S. G. Faruque, M. J. Albert and G. B. Nair. 1998. Heterogeneity in the organization of the CTX genetic element in strains of Vibrio cholerae O139 Bengal isolated from Calcutta, India and Dhaka, Bangladesh and its plausible link to the dissimilar incidence of the O139 cholera in the two locales. Microbiol. Pathogen. 24: 175-183. Pubmed
  5. Bhattacharya, M. K., D. Dutta, S. K. Bhattacharya, A. Deb, A. K. Mukhopadhyay, G. B. Nair, T. Shimada, Y. Takeda, A. Chowdhury and D. Mahalanabis. 1998. Association of a disease approximating cholera caused by Vibrio cholerae of serogroups other than O1 and O139. Epidemiol. Infect. 120: 1-5. Pubmed
  6. Bhattacharya, M. K., D. Dutta, A. Deb, P. Garg, S. Chakraborty, A. K. Mukhopadhyay, S. K. Bhattacharya and A. Moitra. 1998. Acute secretory traveller's diarrhoea caused by Vibrio cholerae which does not belong to the O1 or O139 serogroup. Natl. Med. J. India. 11: 248-249. Pubmed
  7. Mukhopadhyay, A. K., A. Basu, P. Garg, P. K. Bag, A. Ghosh, S. K. Bhattacharya, Y. Takeda and G. B. Nair. 1998. Molecular epidemiology of reemergent Vibrio cholerae O139 Bengal in India. J. Clin. Microbiol. 36: 2149-2152. Pubmed

1997

  1. Okuda, J., M. Ishibashi, E. Hayakaya, T. Nishino, Y. Takeda, A. K. Mukhopadhyay, S. Garg, S. K. Bhattacharya, G. B. Nair and M. Nishibuchi. 1997. Emergence of a unique rapidly disseminating O3: K6 clone of Vibrio parahaemolyticus in Calcutta, India and Southeast Asian countries. J. Clin. Microbiol. 35: 3150-3155. Pubmed
  2. Radhakutty, G., B. K. Sircar, S. K. Mondal, A. K. Mukhopadhyay, R. Mitra, A. Basu, R. L. Ichhpiyini, G. B. Nair and S. K. Bhattacharya. 1997. Outbreak of cholera in Alleppey and Palghat districts, South India: Epidemiological features and virulence traits of epidemic strains. Indian J. Med. Res. 106: 455-457. Pubmed
  3. Basu, A., A. K. Mukhopadhyay, A. K. Chakrabarty, S. K. Niyogi, M.R. Saha, S. Yamasaki, Y. Takeda and G. B. Nair. 1997. Comparison between mutiplex PCR, sensitivity to biotype specific phages and polymixin B for biotyping of Vibrio cholerae O1. Indian J. Med. Res. 106: 491-493. Pubmed
  4. Sharma, C., S. Maiti, A. K. Mukhopadhyay, A. Basu, I. Basu, G. B. Nair, R. Mukhopadhyaya, B. Das, S. Kar, R. K. Ghosh and A. Ghosh. 1997. Unique organization of the CTX genetic element in Vibrio cholerae O139 strains which reemerged in calcutta, India in September, 1996. J. Clin. Microbiol. 35: 3348-3350. Pubmed
  5. Sharma, C., G. B. Nair, A. K. Mukhopadhyay, S. K. Bhattacharya, R. K. Ghosh and A. Ghosh. 1997. Molecular characterization of V.cholerae O1 biotype ElTor strains isolated between 1992 and 1995 in Calcutta, India: Evidence for the emergence of a new clone of the ElTor biotype. J. Infect. Dis. 175: 1134-1141. Pubmed
  6. Mukhopadhyay, A. K., I. Basu, S. K. Bhattacharya, M. K. Bhattacharya and G. B. Nair. 1997. Emergence of fluoroquinolone-resistant strains of Vibrio cholerae isolated from hospitalized patients with acute diarrhoea in Calcutta, India. Antimicrob. Agents Chemother. 42: 206-207. Pubmed

1996

  1. Garg, S., A. N. Ghosh, A. K. Mukhopadhyay and G. B. Nair. 1996. Electron microscopic studies on Vibrio cholerae O139. Indian J. Med. Res. 104: 134-138. Pubmed
  2. Saha, P. K., H. Koley, A. K. Mukhopadhyay, S. K. Bhattacharya, G. B. Nair, B. S. Ramakrishna, S. Krishnan, T. Takeda and Y. Takeda. 1996. Nontoxigenic Vibrio cholerae O1 serotype Inaba biotype ElTor Associated with a cluster of cases of cholera in Southern India. J. Clin. Microbiol. 34: 1114-1117. Pubmed
  3. Dutta, D., S. K. Bhattacharya, M. K. Bhattacharya, A. Deb, M. Deb, A. Moitra, B, Manna, A. K. Mukhopadhyay and G. B. Nair. 1996. Efficacy of norfloxacin and doxycycline for Vibrio cholerae O139 infection. J. Antimicrob. Chemother. 37: 575-581. Pubmed
  4. Mukhopadhyay, A. K., S. Garg, P. K. Saha, Y. Takeda, S. K. Bhattacharya and G. B. Nair. 1996. Comparative analysis of factors promoting optimal production of cholera toxin by Vibrio cholerae O1 (classical and ElTor biotypes) and O139. Indian J. Med. Res. 104: 129-133 Pubmed
  5. Mukhopadhyay, A. K., S. Garg, R. Mitra, A. Basu, D. Dutta, S. K. Bhattacharya, T. Shimada, T. Takeda, Y. Takeda and G. B. Nair. 1996. Temporal shifts in traits of Vibrio cholerae isolated from hospitalized patients in Calcutta: a three-year (1993-1995) analysis. J. Clin. Microbiol. 34: 2537-2543. Pubmed

1995

  1. Hasan, J. A. K., A. Huq, G. B. Nair, S. Garg, A. K. Mukhopadhyay, L. Loomis, D. Bernstein and R. R. Colwell. 1995. Development and testing of monoclonal antibody based rapid immunodiagnostic test kits for direct detection of Vibrio cholerae O139 synonym Bengal. J. Clin. Microbiol. 33: 2935-2939. Pubmed
  2. Sengupta, P. G., B. K. Sircar, S. K. Mondal, A. K. Mukhopadhyay, G. B. Nair, D. N. Gupta, S. Ghosh, N. C. Saha, B. C. Deb, S. N. Sikdar, B. Manna, S. K. Bhattacharya, B. K. Mandal and S. P. Dey. 1995. Epidemiology of Vibrio cholerae O139 with special reference to intrafamilial transmission in Calcutta. J. Infect. 31: 45-47 Pubmed
  3. Niyogi, S. K., P. G. Sengupta, S. K. Bhattacharya, S. Garg, A. K. Mukhopadhyay and G. B. Nair. 1995. Emergence of furazolidone and co-trimoxazole resistant Vibrio cholerae O1 in Eastern India. J. Infect. 30: 265-266. 63. Pubmed
  4. Mukhopadhyay, A. K., S. Garg, G. B. Nair, S. Kar, R. K. Ghosh, S. Pajni, A. Ghosh, T. Shimada, T. Takeda and Y. Takeda. 1995. Biotype traits and antibiotic susceptibility of Vibrio cholerae serogroup O1 before, during and after the emergence of the O139 serogroup. Epidemiol. Infect. 115: 427-434. 64. Pubmed
  5. Mukhopadhyay, A. K., P. K. Saha, S. Garg, S. K. Bhattacharya, T. Shimada, T. Takeda, Y. Takeda and G. B. Nair. 1995. Distribution and virulence of Vibrio cholerae belonging to serogroups other than O1 and O139: A nationwide survey. Epidemiol. Infect. 114: 65-70. Pubmed

1994

  1. Bhattacharya, S. K., M. K. Bhattacharya, D. Dutta, S. Garg, A. K. Mukhopadhyay, M. Deb, A. Moitra and G. B. Nair. 1994. Vibrio cholerae O139 in Calcutta. Arch. Dis. Child. 71: 161-162. Pubmed
  2. Nair, G. B., T. Shimada, H. Kurazono, J. Okuda, A. Pal, T. Karasawa, T. Mihara, Y. Uesaka, H. Shirai, S. Garg, P. K. Saha, A. K. Mukhopadhyay, T. Ohashi, J. Tada, T. Nakayama, S. Fukushima, T. Takeda and Y. Takeda. 1994. Characterization of phenotypic, serological and toxigenic traits of Vibrio cholerae O139 Bengal. J. Clin. Microbiol. 32: 2775-2779. Pubmed
  3. Nair, G. B., S. Garg, A. K. Mukhopadhyay, T. Shimada and Y. Takeda. 1994. Laboratory diagnosis of Vibrio cholerae O139 Bengal, the new pandemic strain of cholera. LabMedica International. XI: 8-11.68.
  4. Nair, G. B., T. Ramamurthy, S. K. Bhattacharya, A. K. Mukhopadhyay, S. Garg, M. K. Bhattacharya, T. Takeda, T. Shimada, Y. Takeda and B. C. Deb. 1994. Spread of Vibrio cholerae O139 Bengal in India. J. Infect. Dis. 169: 1029-1034. Pubmed
  5. Garg, S., T. Ramamurthy, A. K. Mukhopadhyay, B. C. Deb, G. B. Nair, T. Shimada, T. Takeda, A. Huq, R. R. Colwell and Y. Takeda. 1994. Production and cross reactivity patterns of a panel of high affinity monoclonal antibodies to Vibrio cholerae O139 Bengal. FEMS. Immunol. Med. Microbiol. 8: 293-298. Pubmed

Book Chapters

  1. Mukhopadhyay A. K., Y. Takeda, G. B. Nair. 2014. Cholera Outbreaks in the El Tor Biotype Era and the Impact of the New El Tor Variants. Curr Top MicrobiolImmunol. Vol. 379, p17-48. In G.B. Nair and Y Takeda (eds), Cholera Outbreaks. Springer New York.
  2. Ramamurthy T., A. K. Mukhopadhyay, R. K. Nandy and G.B. Nair. 2013. Molecular Typing of Vibrio cholerae: Imprints in the Epidemiology of Cholera. P53-72. In I. de Filippis and M.L. McKee (eds.), Molecular Typing in bacterial Infections. Humana Press; Springer. New York.
  3. Banerjee A., A. K. Mukhopadhyay, S. Paul, A. Bhattacharyya and S. Swarnakar. 2013. "Unveiling the Intricacies of Helicobacter pylori-Induced Gastric Inflammation: T Helper Cells and Matrix Metalloproteinases at a Crossroad" p114-151. In: G. Mozsik (ed); "Current Topics in Gastritis - 2012" (ISBN 978-953-51-0907-5) InTech publisher, Rijeka, Croatia.
  4. Nair, G.B., A.K. Mukhopadhyay, A. Safa, and Y. Takeda. 2008. Emerging hybrid variants of Vibrio cholerae O1, p179-190. In S. M. Faruque(ed), Vibrio cholerae: Genomics and Molecular biology. Horizon Scientific Press. Norwich, UK.
     

  5. Mukhopadhyay A.K., and G.B. Nair. 2011. The Rapid Diagnosis of Cholera: Where Do We Stand? p128-146. In D. Raghunath, V. Nagaraju (ed), Diagnostics in Infections. Macmillan Publishers India Ltd.
  6. Mukhopadhyay A.K., T. Ramamurthy. 2010. Asiatic Cholera: Mole Hills and Mountains. P5-29. In T. Ramamurthy, S.K. Bhattacharya (eds.), Epidemiological and Molecular Aspects on Cholera. Humana Press; Springer. http://www.springer.com/978-1-60327-264-3

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