ICMR - NICED


ICMR-National Institute of Cholera and Enteric Diseases

आई सी एम आर - राष्ट्रीय कॉलरा और आंत्र रोग संस्थान

Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
WHO Collaborating Centre For Research and Training On Diarrhoeal Diseases

NICED : Scientists

Dr. Alok Kumar Chakrabarti

Dr. Alok Kumar Chakrabarti

General Information
Name Dr. Alok Kumar Chakrabarti
Designation Scientist E
Date of joining ICMR 18th September 2006
Date of joining present post 1 September 2015
Discipline Virology, Molecular Biology, Bacteriophage
Division Virology
Specialization Virology
Email : chakrabarti.alok@icmr.gov.in , aloke8@yahoo.com
Academic Qualification  
Graduation B.Sc. University of Calcutta
Post Graduation M.Sc. University of Calcutta
Doctoral Ph.D. University of Calcutta

Profile

Professional Experience

After receiving M.Sc degree from University of Calcutta he joined as a junior research fellow at the National Institute of Cholera and Enteric Diseases. His research work on Vibrio cholerae O139 bacteriophages resulted in the development of a phage typing scheme for the identification and discrimination of highly virulent Vibrio cholerae O139 which is in routine use for nationwide screening of phage types of Vibrio cholerae O139. After completion of his PhD work, he moved to USA as a post-doctoral researcher where he gained expertise on virology. He worked on generation of recombinant influenza viruses to use influenza virus as a vector for gene transfer at UCLA Los Angeles. At UTMB, Galveston he performed research on replication of HIV-1. Afterwards he joined National Institute of virology, Pune as a regular faculty and worked on influenza viruses. Consequently he became in charge of Microarray Division at the National Institute of Virology. His research at NIV, Pune on molecular diagnostics of influenza contributed largely in management of bird flu outbreak in India. He developed reverse genetics modified vaccine strain for the highly pathogenic H5N1 influenza A viruses in collaboration with CDC, Atlanta, USA. His work on host influenza virus interactions revealed that delicate differences in the ability to induce specific host responses like apoptotic mechanism and immune responses make the highly pathogenic viruses (H5N1) more virulent. His work also attributed the high transmissibility of pH1N1 virus in the year 2009-2010 to its better subversion of host immune responses compared to the seasonal influenza viruses. Besides research and training Dr Chakrabarti also worked as a faculty for teaching MSc Virology at National Institute of Virology, Pune University for 10 years and also worked as invited faculty for the Department of Biotechnology at Pune University. Other than working for many institutional committees at NIV, he was also the in-charge of NIV library as an additional charge.

He joined NICED as Scientist in July, 2016 and working on respiratory viruses.His research involves viral diagnostics and host-virus interactions. Here at ICMR-NICED he is also involved in phage typing of V.cholerae O1 biotype ElTor strains.
 

Research Interests

His field of research interest includes work on respiratory viruses, as well as host-pathogen interactions. A major focus of his research is on influenza viruseswhich are one of the globally important human pathogens and a leading public health risk problem. Emergence of highly pathogenic avian influenza (HPAI) strains and pandemic H1N1 indicated a persistent need to work on influenza viruses to understand the pathogenesis of influenza A and development of vaccines and therapies. He is working on investigating the molecular pathogenesis and biology of influenza viruses. Phage typing of Vibrio cholerae is an ongoing activity of ICMR-NICED. He is working in pahge typing of V.cholerae and characterization of cholera bacteriophages.

Membership of Association

The Indian Science Congress Association

Awards

  • Prof A K Mukherjee Memorial Gold Medal, 1993
  • Junior Research Fellowship from Indian Council of Medical Research
  • Senior Research Fellowship Indian Council of Medical Research

Students:

  • Mr Partha Pratim Mondal, JRF
  • Mr. Devendra Nath Tewari, JRF
    .

Travel to foreign countries to attend conference/meetings

The Indian Science Congress Association

  • As per the invitation form the organizer committee Dr. Chakrabarti attended a conference entitled "Alternative Approaches to Combatting Anti-Microbial Resistance (AMR)" in Almaty, Kazakhstan between April 18-19, 2019 and delivered a talk on "Use of bacteriophages in typing of Vibrio cholerae strains in India"

Publications

2020

  1. Biswas A, Bhattacharjee U, Chakrabarti AK, Tewari DN, Banu H, Dutta S. Emergence of Novel Coronavirus and COVID-19: whether to stay or die out?. Crit Rev Microbiol. 2020Mar; 46(2):182-193. Pubmed
  2. Chakrabarti AK, Biswas A, Tewari DN, Mondal PP, Dutta S. Phage types of Vibrio cholerae 01 biotype ELtor strains isolated from India during 20122017. J Global Infect Dis 2020; 12(2):94-100.

2019

  1. Biswas A, Chakrabarti AK, Dutta S. Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 9:1-16. doi: 10.1080/08830185.2019.1685990. [Epub ahead of print]   Pubmed

2018

  1. Pasricha G, Mukherjee S, Chakrabarti AK. Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells. Adv Virol. 2018 Dec 31;2018:5057184.  Pubmed

2017

  1. Sarkar S, Das M, Bhowmick TS, Koley H, Atterbury R, Chakrabarti AK, Sarkar BL. Isolation and Characterization of Novel Broad Host Range Bacteriophages of Vibrio cholerae O1 from Bengal. J Glob Infect Dis. 2018 Apr-Jun;10(2):84-88. Pubmed
  2. Patil S, Shetty P, Kulkarni R D, Ajantha GS, Kalabhavi A, Patil D, Hosamani M, Jain P, Chakraborti A.K. and Shubhada C. Antibiogram and Serotyping of Vibrio cholerae O1 Isolates from a Tertiary Care Centre in South India. J Pure Applied Microbiol 2017 Jun; 11:2 1039-1043

2016

  1. Sarkar BL, Chakrabarti AK, Sarkar S and Dutta S. Vibriophage and Cholera Disease. Indian J.Applied.Microbiol. 2016; 19(2): 9-20.

2015

  1. Muthulakshmi, S., Chakrabarti, AK.and Mukherjee, S. Gene expression profile of high-fat diet-fed C57BL/6J mice: in search of potential role of azeliac acid. J PhysiolBiochem 71:1(2015) 29-42

2014

  1. Pasricha, G., Mukherjee, S. and Chakrabarti, AK*. Comprehensive sequence analysis of HA protein of H7 subtype avian influenza viruses: an emphasis on mutations in novel H7N9 viruses. Future Virol 9 (2014) 251-273.

2013

  1. Mukherjee, S. Vipat, VC. andChakrabarti, AK*. Infection with Influenza A viruses causes changes in promoter DNA methylation of inflammatory genes. Influenza Other Respi Viruses 7:6(2013) 979-86.
  2. Chakrabarti, AK*.andPasricha, G. An insight into the PB1F2 protein and it multifunctional role in enhancing the pathogenicity of the Influenza A viruses. Virology. 440:2 (2013) 97-104.
  3. Pasricha, G., Mishra, AC., and Chakrabarti, AK*. Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the Influenza A virus subtypes responsible for the 20th century pandemics. Influenza Other Respi Viruses. 7:1(2013) 497-505

2012

  1. Mukherjee, S. and Chakrabarti, AK*.Impact of Microarray Technology in Influenza Virus Research and Diagnostics. J Proteomics Bioinform S6 (2012), 002
  2. Mukherjee, S., Majumdar, S., Vipat, VC., Mishra, AC., and Chakrabarti, AK.* Non Structural protein of Avian Influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing Apoptosis in host cells. Virol J 6:9(2012)149

2011

  1. Mukherjee, S., Vipat, VC., Mishra, AC., Pawar, S.D. and Chakrabarti, AK.* Pandemic (H1N1) 2009 influenza virus induces weaker host Immune Responses in vitro a possible mechanism of high transmissibility. Virol J 8:7 (2011) 140.

2010

  1. Chakrabarti, AK.*, Vipat, VC., Mukherjee, S., Singh, R., Pawar, SD. and Mishra, AC. Host gene expression profiling in influenza a virus-infected lung epithelial (A549) cells a comparative analysis between highly pathogenic and modified H5N1 virus. Virol J 7 (2010) 219.
  2. Pawar, S., Chakrabarti, A., Cherian, S., Pande, S., Nanaware, M., Raut, S., Pal, B., Jadhav, S., Kode, S., Koratkar, S., Thite, V. and Mishra, V. A novel avian infleunza A (H11N1) virus from wild aquatic bird revealing a Eurasian -Amricana genetic reassortment. Virus Genes 4:1 (2010) 14-22

2009

  1. Chakrabarti, AK., Pawar, SD., Cherian, SS., Koratkar, S., Jadhav, SM., Pal, B., Raut, S., Thite, V., Kode, SS., Mullick, J. and Mishra, AC. Characterization of the influenza A H5N1 viruses of the 2008-09 outbreaks in India reveals a third introduction and possible endemicity in the region. PloS One.4 (2009) e7846.
  2. Mishra, AC., Cherian, SS., Chakrabarti, AK.,Pawar, SD., Jadhav, SM., Pal, B., Raut, S., Koratkar, S. and Kode, SS. A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India.Virol J 6(2009) 26.
  3. Pawar, SD., Pande, S., Jamgaonkar, A., Koratkar, S., Pal, B., Raut, S., Nanaware, M., Ray, K., Chakrabarti, AK. andKode, S. Avian influenza surveillance in wild migratory, resident domestic birds and in poultry in Maharashtra and manipur, India, during avian migratory season 2006-07. CurrSci 97 (2009) 550.

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